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Active clinical trials for "Carcinoma, Hepatocellular"

Results 91-100 of 2402

Atezolizumab and Bevacizumab Before Surgery for the Treatment of Resectable Liver Cancer

Resectable Hepatocellular CarcinomaStage I Hepatocellular Carcinoma AJCC v83 more

This phase II trial studies the effect of atezolizumab and bevacizumab before surgery in treating patients with liver cancer that can be removed by surgery (resectable). Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Bevacizumab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. Giving the combination of atezolizumab and bevacizumab may help to prevent liver cancer from returning after surgery.

Recruiting66 enrollment criteria

Camrelizumab Combined With Apatinib for Perioperative Treatment of Resectable Primary Hepatocellular...

Resectable Hepatocellular Carcinoma

This is A prospective, one-arm, phase II clinical study of Camrelizumab combined with apatinib for perioperative treatment of resectable primary hepatocellular carcinoma with a high risk of recurrence

Recruiting39 enrollment criteria

Cabozantinib Treatment in a Phase II Study for Patients With Hepatocellular Carcinoma (HCC) Refractory...

Hepatocellular Carcinoma

The CaPture trial is a prospective, multi-centre, non-randomized phase II study. Its aim is to assess feasibility, safety and efficacy signals of Cabozantinib treatment in patients with HCC and prior non-response or disease progression during a PD-1 or PD-L1 inhibitor treatment. Since the potential study population is very small, the sample size has been fixed in advance to N = 40. Time on treatment (TT) will be measured as primary endpoint.

Recruiting42 enrollment criteria

A Study to Assess the Safety and Efficacy of Lenvatinib as First-line Treatment in Participants...

CarcinomaHepatocellular

The primary objective of this study is to evaluate the safety of lenvatinib in HCC.

Recruiting56 enrollment criteria

TACE Combined With Anti-PD-1 Antibody in Patients With Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma

The objective of this study is to evaluate the efficacy and safety of transcatheter arterial chemoembolization combined with anti-pd-1 antibody in patients with advanced hepatocellular carcinoma as first line therapy.

Recruiting42 enrollment criteria

Cabozantinib to Treat Recurrent Liver Cancer Post Transplant

Hepatocellular CarcinomaRecurrent Cancer1 more

This is a phase 2 study that will assess the investigational drug, cabozantinib, in patients with liver cancer (specifically hepatocellular carcinoma) and who had received a liver transplant as a part of curative care, but the cancer has come back (recurred). The purpose of this study is to see how useful cabozantinib is in controlling the disease of these patients. Cabozantinib blocks the function of various proteins found on the surface of the body's cells (called receptor tyrosine kinases) that are important in the development of cancer tumors. All participants will receive cabozantinib until they are no longer receiving benefit from the study drug or they experience an intolerable side effect.

Recruiting40 enrollment criteria

A Study of Atezolizumab and Bevacizumab in Hepatocellular Carcinoma

Unresectable Hepatocellular Carcinoma

This will be a nonrandomized, single arm feasibility study with the primary goal of evaluating the safety profile of the combination of atezolizumab and bevacizumab in patients with advanced/metastatic HCC with Child-Pugh B7 and B8 liver disease who have received no prior systemic therapy.

Recruiting92 enrollment criteria

Intra-tumor Injection of Drug-eluting Microspheres

Hepatocellular CarcinomaSolid Tumor1 more

To study the safety and clinical effect of injection of drug-eluting microspheres into advanced solid tumors.

Recruiting7 enrollment criteria

Neo-TACE-HAIC for High-risk BCLC A Stage HCC (NeoconceptA)

Hepatocellular Carcinoma

Hepatocellular carcinoma (HCC) patients is a common disease in the East Asia. Although resection was recommend for early stage (BCLC A stage) patients according to the BCLC (Barcelona clinical liver cancer) system, increasing studies suggested that preoperative transarterial therapy may decrease the recurrence risk for those with high-risk factors. However, the clinical value is still undertermined. Recently, FOLFOX (Oxaliplatin and 5-fluorouracil) based hepatic artery infusion chemotherapy (HAIC) exhibited high response rate for unresectable HCC. Pilot study showed TACE combined HAIC (TACE-HAIC) had better tumor response, with low progression disease rate. Whether TACE-HAIC would improve survival for BCLC A stage patients with high-risk factors is need to further to study. A randomized clinical trial compared neo-TACE-HAIC with surgery versus surgery alone is aimed to answer this question.

Recruiting9 enrollment criteria

The ABC-HCC Trial: Atezolizumab Plus Bevacizumab vs. Transarterial Chemoembolization (TACE) in Intermediate-stage...

Hepatocellular Carcinoma

The ABC-HCC trial is a Phase IIIb, randomised, multicenter, open-label study designed to evaluate the safety and efficacy of atezolizumab plus bevacizumab versus TACE in patients with intermediate-stage HCC. Approximately 434 patients in two arms of treatment will be enrolled.

Recruiting79 enrollment criteria
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