Decision Support Intervention Adapted for HIV Pre-Exposure Prophylaxis for Adoption and Adherence...
HIV/AIDSAim 1: Adapt Ottawa Decision Support Framework for the HIV PrEP decisional needs of African, Caribbean and Black (ACB) Canadian patients Aim 2. Pilot Test The Adapted Decision-Support Intervention Using a Two-Arm Randomized Controlled Design
Mindful Living With Stress for Nurses Caring for HIV/AIDS Patients in China
StressThe primary objective of this proposed one-year (January 01, 2017 to December 31,2017) project is to assess whether a mindfulness based intervention('Mindful Living With Stress') will be effective at helping nurses caring for HIV/AIDS patients in China to reduce stress. Based on the efficacy of previous studies in stress reduction, it is hypothesized that 'Mindful Living With Stress' will be an effective, feasible and affordable stress reduction program in China.
Study of Single IV Administration of P2G12
HIV InfectionA randomised phase I trial of a monoclonal antibody which neutralises HIV-1 (P2G12) to be given as a single intravenous infusion to healthy human volunteers to assess the safety and reactogenicity
Monitoring Pre-exposure Prophylaxis for Young Adult Women
HIV/AIDSAdherenceNext generation real-time monitoring for PrEP adherence in young Kenyan women
Exploratory Study of Cellular Reservoirs in Blood From HIV Infected Patients
HIV InfectionThis study evaluates the impact of highly active antiretroviral therapy on the size of the latent viral reservoirs in resting CD4+ T cells and monocytes in HIV positive patients. The activation state of the cells will be assessed, by measuring the activation of Akt, to determine its influence on the size of the viral reservoirs.
Study Among People Living With HIV and Their Health Professionals of Associated Factors of Resilience...
HIV InfectionsThis study is perform to study the effect of psychological and psychosocial factors associated with resilience to the self-stigmatization of people living with HIV
Friends for Life Circles for Option B Plus
Human Immunodeficiency VirusThe main goal of the study is to support HIV-infected pregnant women initiated on PMTCT Option B+ during antenatal to adhere to lifelong ART and postpartum care visits through an enhanced group peer support intervention called "friends for life circles".
Inflammatory Pathogenesis of Coronary Atherosclerosis in HIV
Coronary Artery DiseaseHuman Immunodeficiency VirusThe investigators are studying whether an anti-inflammatory intervention improves impaired coronary endothelial function (CEF) in HIV+ people with no clinical coronary artery disease (CAD).
A Trial to Assess the Functionality of Female Condom With a Silicone Elastomer Vaginal Ring
Human Immunodeficiency VirusA multi-center, open-label, randomized, two-period, crossover non-inferiority trial to assess the functionality of female condoms with a silicone elastomer vaginal ring.
Pharmacokinetic Evaluation of Changes in Nevirapine AUC Due to Differences in Weight
HIV InfectionThis study would be a prospective cohort study, stratified by weight. Patients who are stable on nevirapine for at least 3 months prior to study entry, but no more than 1year will be recruited. For 1 week, subjects will take their morning dose of nevirapine in the clinic (and be observed taking it), and given their evening dose to take at home. Subjects will need to record the date and time they take their evening dose. At the end of the week, the subjects will be sequestered at the clinic for blood draws for a 12hr pharmacokinetic sampling. They will not be brought back in at 24hrs as they will need to be redosed after 12hrs. They will have Liver Function Tests (LFT's) and other labs drawn at study entry, and one month after the end of study. Pharmacokinetic levels will be analyzed using standard mathematical models, and Area Under the Curve (AUC), Maximum concentration (Cmax), and Minimum Concentration (Cmin) will be compared between groups.