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Active clinical trials for "Influenza, Human"

Results 391-400 of 1970

Project STARFISH - PRJ0002679

SARS-CoV-2 InfectionInfluenza A2 more

This is a non-interventional study to perform the clinical performance evaluation of the Starfish Test using prospectively collected matched nasopharyngeal and nasal swab samples from the same donor. In order to meet the minimum sample requirements, and to demonstrate performance on a range of viral strains, the prospective collection may be supplemented with banked remnant nasal and/or nasopharyngeal samples.

Active6 enrollment criteria

The Research of Novel Electrolyzed Water Spray to Eradicate Bacteria E-coli and an Attenuated Human...

Bacterial GrowthNovel Influenza A (H1N1)

The purpose of this study is to test whether spraying the hand of patients by use of the novel electrolyzed water spray will decrease the number of bacteria E-coli and the virus titer of an attenuated human flu virus.

Completed11 enrollment criteria

Influenza Vaccine To Prevent Adverse Vascular Events:Pilot

Heart Failure

A multi-centre, randomized, placebo controlled, trial. Participants at high-risk for vascular events from the network of INTER- CHF will be randomized to inactivated influenza vaccine or placebo and followed prospectively over three influenza seasons. 600 participants will be enrolled prior to influenza season and randomized to either influenza vaccine or saline placebo.

Completed6 enrollment criteria

Effect of Oseltamivir on Cognitive Function in Subjects With Influenza

Influenza

This study has been designed to determine if subjects treated with oseltamivir in addition to standard of care treatment for influenza demonstrate a greater improvement in attention / working memory / processing speed / mood as compared to subjects receiving standard of care alone. The cognitive tests employed are objective measures developed and administered online by HeadMinder Inc.

Completed26 enrollment criteria

Trial to Investigate Viral Shedding in Healthy Children Vaccinated With Vaccine Virus Liquid (CAIV-T)...

Influenza

The primary objective of this study was to determine the proportion of subjects, seronegative to all three strains of influenza, as defined by a serum hemagglutination inhibition antibodies (HAI) antibody titer of <1:10, who shed each vaccine virus strain following a single dose of CAIV-T.

Completed12 enrollment criteria

Adaptive Immune Responses and Repertoire in Influenza Vaccination and Infection (SLVP031)

Influenza

The purpose of this study is provide a better understanding of the adaptive immune response to the licensed flu vaccines. The investigators hope the information learned from this study will help identify and describe important factors of influenza immunity especially of or specific proteins associated with the T-cell immune response.

Terminated31 enrollment criteria

Tissue-specific Responses to Influenza Immunization and Their Relation to Blood Biomarkers (SLVP032)...

Influenza

The investigators collected blood and lymphoid tissues routinely discarded during surgery from adults after a routine seasonal influenza vaccination to determine how immune memory develops at the actual site of infection, and how immunization may alter this process.

Terminated31 enrollment criteria

The Impact of Imprinting and Repeated Influenza Vaccination on Adaptive Immunity, Transcriptomics,...

Influenza

The goal of this study is to understand the impact on the human immune system's response to the four strain flu vaccine in individuals who have "imprinted" on specific influenza strains. It will also consider the effects of repeated prior annual influenza vaccination on the immune system.

Terminated22 enrollment criteria

Evaluating Immune Response to Seasonal FluMist in Healthy Adults

Influenza

The Live-Attenuated Influenza Vaccine (LAIV), also known as FluMist, has been shown to be effective in children but less effective in adults. Our hypothesis is that this relative failure is due to adults having enough anti-flu IgA antibody in nasal secretions to neutralize the weakened vaccine virus.

Terminated8 enrollment criteria

A Trial of Oseltamivir in High-Risk Patients Presenting to the Emergency Department With Influenza...

Influenza

A multi-centre, randomized, placebo controlled, trial. Participants will be patients either ≥65 years or with one or more high risk conditions presenting to one of four academic emergency departments in Edmonton or Calgary with influenza-like illness. The investigators will test for influenza using a point-of-care rapid test and if positive for influenza participants will be randomized to oseltamivir or placebo and followed prospectively. The primary outcome will be hospitalization.

Terminated14 enrollment criteria
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