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Active clinical trials for "Huntington Disease"

Results 1-10 of 236

The Safety and Tolerability Study With ER2001 Intravenous Injection in Adults With Early Manifest...

Huntington Disease

This is an open label, dose escalation clinic trial of ER2001 intravenous injection to evaluate safety, tolerability and pharmacokinetics of ascending single and multiple doses of intravenously administered ER2001 in patients with early manifest Huntington's Disease. Furthermore, pharmacodynamics in particular target engagement, and early clinical signs of efficacy will be assessed. This study will evaluate increasing doses of ER2001 in sequential cohorts. ER2001 was escalated over 4 dose levels . The planned duration of this treatment is 14 weeks.

Recruiting28 enrollment criteria

Efficacy and Safety on SOM3355 in Huntington's Disease Chorea

Huntington Chorea

Phase IIb, randomized, double-blind, placebo-controlled study in parallel groups assessing the efficacy and safety of two doses of SOM3355 in patients suffering from Huntington's Disease with choreic movements.

Recruiting22 enrollment criteria

A Study to Evaluate the Safety and Efficacy of PTC518 in Participants With Huntington's Disease...

Huntington Disease

The primary goal of this study is to evaluate the safety and pharmacodynamic effects of PTC518 compared with placebo in participants with HD.

Recruiting16 enrollment criteria

A Pilot Study Assessing Impulsivity in Patients With Huntington's Disease on Xenazine (Tetrabenazine)...

Huntington's Disease

The purpose of this research study is to see if tetrabenazine, which is commonly used to treat Huntington's Disease (HD), reduces the problems of impulsivity that are common in patients with HD. Investigators will also see how the medicine affects aspects of thinking and mood.

Recruiting8 enrollment criteria

Safety and Proof-of-Concept (POC) Study With AMT-130 in Adults With Early Manifest Huntington's...

Huntington's Disease

This is the first study of AMT-130 in patients with early manifest HD and is designed to establish safety and proof-of-concept (PoC). CT-AMT-130-01 is a Phase I/II, randomized, multicenter, multiple dose, double-blind, imitation surgery, first-in-human (FIH) study. Cohort 3 participants will receive either high or low dose (1:1 randomization).

Recruiting23 enrollment criteria

GENERATION HD2. A Study to Evaluate the Safety, Biomarkers, and Efficacy of Tominersen Compared...

Huntington Disease

This study will evaluate the safety, biomarkers, and efficacy of tominersen compared with placebo in participants with prodromal and early manifest Huntington's Disease.

Recruiting16 enrollment criteria

Study of WVE-003 in Patients With Huntington's Disease

Huntington Disease

This is a Phase 1b/2a multicenter, randomized, double-blind, placebo-controlled study to evaluate the safety, tolerability, PK, and PD of WVE-003 in adult patients with early-manifest HD who carry the targeted single nucleotide polymorphism (SNP) - SNP3.

Recruiting11 enrollment criteria

Symptomatic Therapy for Patients With Huntington's Disease

Huntington Disease

Based on the previous symptomatic treatment of Chinese HD patients, this study intends to further optimize the treatment regimen of Chinese HD patients so as to further improve the prognosis of patients.

Recruiting5 enrollment criteria

Deep Brain Stimulation Treatment for Chorea in Huntington's Disease

Huntington DiseaseDeep Brain Stimulation

Evaluating therapeutic effects of globus pallidus internus (GPi) deep brain stimulation (DBS) on Huntington's disease (HD) patients with chorea; Explore the relationship between brain network conditions and DBS efficacy in HD patients Explore the effect of different programmed parameters on the treatment of patients with DBS

Recruiting13 enrollment criteria

Move to Improve: Telehealth Exercise to Music for HD

Huntington Disease

The purpose of this study is to determine if a movement to music exercise program delivered via telehealth is feasible and safe for individuals with neurodegenerative disease and their caregivers (Aim 1). A secondary aim will be to determine if a movement to music exercise program delivered via telehealth improves balance, cognition, mobility, and quality of life (Aim 2).

Recruiting11 enrollment criteria
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