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Active clinical trials for "Hydrocephalus"

Results 1-10 of 174

Pilot Study to Evaluate the CereVasc® eShunt® System in the Treatment of Communicating Hydrocephalus...

HydrocephalusHydrocephalus1 more

The purpose of this study will be to evaluate a novel, minimally invasive method of treating hydrocephalus in adults. The eShunt® System includes a proprietary eShunt® Delivery System and the eShunt® Implant, a permanent implant that is deployed in a mildly invasive, neuro-interventional procedure. The eShunt® Implant is designed to drain excess cerebrospinal fluid (CSF) from the intracranial subarachnoid space (SAS) into the venous system.

Recruiting29 enrollment criteria

Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

HydrocephalusNormal Pressure1 more

The eShunt System includes proprietary delivery componentry and the eShunt Implant, a permanent implant deployed in a minimally invasive, neurointerventional procedure. The eShunt Implant is designed to mimic the function of the arachnoid granulations by draining excess cerebrospinal fluid (CSF) from the intracranial subarachnoid space (SAS) into the venous system.

Recruiting29 enrollment criteria

Normal Pressure Hydrocephalus and Sleep Apnea

Normal Pressure HydrocephalusSleep Apnea1 more

Normal-pressure hydrocephalus is associated with increases in the intracranial pressure during the night sleep. Sleep apnea also increases the intracranial pressure during the apneic spells. When patients are operated the distal part of the shunt is inserted inside the abdominal cavity, which pressure also increases during the sleep apnea episodes. this is particularly important considering that the recumbent position used to sleep further increases the intraabdominal pressure and that impairs the CSF drainage through the shunt system. The purpose of this study is to analyze the intracranial and intraabdominal pressures during the sleep, particularly during the sleep apnea episodes to see which shunt should be used, to which cavity should be drained (peritoneum or heart) and if correcting the sleep apnea has some positive result on the hydrocephalus symptoms.

Recruiting4 enrollment criteria

The Effects of Exercise on Gait Characteristics, Balance, and Performance in Patients With Normal...

NPH (Normal Pressure Hydrocephalus)

The goal of this study is to investigate effect of exercise program on balance, gait and performance in patients with normal pressure hydrocephalus applied with lumbar puncture. The main question it aims to answer are: Home based exercise program effective on balance, gait and performance Telerehabilitation exercise program effective on balance, gait and performance Researchers will compare home based exercise group, telerehabilitation group and control group to see if difference in terms of balance, gait and performance

Recruiting5 enrollment criteria

Efficacy in iNPH Shunting (PENS) Trial

Idiopathic Normal Pressure Hydrocephalus (INPH)

The Placebo-Controlled Efficacy in Idiopathic Normal Pressure Hydrocephalus (iNPH) Shunting (PENS) trial is a multi-center blinded, randomized, placebo-controlled design investigation of cerebrospinal fluid (CSF) shunt surgery to study the shunt efficacy in iNPH patients.

Recruiting20 enrollment criteria

US Pilot Study of the CereVasc® eShunt® System in Normal Pressure Hydrocephalus

HydrocephalusNormal Pressure1 more

The eShunt® System is a minimally invasive method of treating communicating hydrocephalus. The eShunt System includes a proprietary eShunt Delivery System and the eShunt Implant, a permanent implant deployed in a minimally invasive, neuro-interventional procedure. The eShunt System is intended to shunt cerebrospinal fluid from the intracranial subarachnoid space to the venous system for the treatment of patients with normal pressure hydrocephalus, reducing disability due to symptoms including one or more of gait disturbance, cognitive dysfunction and urinary incontinence.

Recruiting27 enrollment criteria

Idiopathic Normal Pressure Hydrocephalus: Focus on Imaging and Clinical Symptoms.

Fecal Incontinence With Fecal UrgencyUrine Incontinence2 more

LiNPH is a prospective single center clinical and radiological study.

Recruiting2 enrollment criteria

Danish RAndomized Trial of External Ventricular Drainage Cessation IN Aneurysmal Subarachnoid Haemorrhage...

Aneurysmal Subarachnoid HemorrhageHydrocephalus

The DRAIN trial is an international multi-centre, 1:1 randomised, parallel-group, superiority clinical trial investigating gradual weaning vs. prompt closure of external ventricular drainage in patients with hydrocephalus following aSAH. The primary objective is to investigate the beneficial and harmful effects of gradual weaning versus prompt closure of EVD treatment in patients with aSAH.

Recruiting10 enrollment criteria

Acetazolamide Trial in Normal Pressure Hydrocephalus

Idiopathic Normal Pressure Hydrocephalus (INPH)

A pharmacological treatment to patients with normal pressure hydrocephalus (NPH) is missing. The aim is to investigate if acetazolamide given to patients with NPH improves gait function and study the pathophysiological mechanisms leading to reduced symptoms. Patients will be randomized to acetazolamide or placebo and duration of treatment will be from diagnosis to the day of shunt surgery. Target dose is 500 mg/day. Study design is a double-blind randomized controlled trial and the plan is to include 42-50 patients. The study is investigator-initiated without financial sponsorship from the industry.

Recruiting20 enrollment criteria

Improvement of Peritoneal Catheter Placement in VPS With a Splitable Trocar

Hydrocephalus

This study is a phase I/IIa, single-center, open-labeled, randomized, controlled clinical trial. The aim of this study is to evaluate the safety and efficacy of a modified ventriculoperitoneal catheter placement using a splitable trocar for ventriculoperitoneal shunt.

Recruiting8 enrollment criteria
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