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Active clinical trials for "Hyperlipidemias"

Results 61-70 of 695

A Real World Research: Comparison of Precision and Experience Therapy for Hypertension, Diabetes...

Hypertension,EssentialDiabetes type21 more

The purpose of this study is to evaluate the effectiveness, safety and health economics of precise drug use strategies based on pharmacogenomics compared with traditional drug use strategies for cardiovascular related chronic diseases.

Active16 enrollment criteria

Unmet Social Needs Study

Cardiovascular DiseaseHypertension2 more

The impacts of unmet social needs, such as homelessness, inconsistent access to food, and exposure to violence on health are well-established, especially for cardiovascular disease. A limited but growing body of evidence suggests that screening for and addressing these needs - also referred as social determinants of health -- in clinic settings helps to connect patients to resources to address unmet needs and has the potential to improve health outcomes. Veterans carry a high burden of unmet needs. At present, VA systematically screens for only two unmet needs; homelessness and food insecurity. The investigators propose to assess the efficacy of systematically screening Veterans for nine unmet needs (i.e., housing, food insecurity, utility insecurity, transportation, legal problems, employment, safety, stress, and social isolation), and compare the effect of referral mechanisms of varying intensity on Veterans' connection to resources, reduction of unmet needs, treatment adherence, reduced preventable hospitalizations, and clinical outcomes.

Active12 enrollment criteria

Gamification and Medication Adherence (GAME Adherence)

Hypertension and Hyperlipidemia

A two-arm randomized controlled trial to evaluate whether a gamification intervention plus involvement of a supportive partner (social support) and sending reports to physicians (accountability) increases medication adherence in patients with hypertension and hyperlipidemia. The study will randomize 84 patients with hypertension, hyperlipidemia, and a history of poor medication adherence seen in a single Penn Medicine clinic to an 18-week gamification intervention or to attention control text messages alone.

Active9 enrollment criteria

Veteran Peer Coaches Optimizing and Advancing Cardiac Health

Cardiovascular Disease (CVD)Hypertension2 more

The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor. The intervention will deliver brief health messages, discuss goal setting, and action planning around health behavior changes shown to decrease CVD risk, including healthy diet, regular to moderate-intensity physical activity, and smoking cessation. Facilitators, barriers, and costs of the intervention will be determined.

Active9 enrollment criteria

Akkermansia Muciniphilia and Metabolic Side Effects of ADT

Prostate CancerMetabolic Syndrome5 more

The overriding objectives of this study are: Primary outcomes: To confirm that administration of oral acetate increases the proportion of A. muciniphilia in the stool samples of patients with metastatic, castration-sensitive prostate cancer compared to placebo. To confirm tolerability and assess for side effects of delayed oral acetate supplementation. Secondary outcomes: To determine if increased counts of A. muciniphilia correlate with improved metabolic parameters and improved bone health.

Not yet recruiting9 enrollment criteria

Long Term Efficacy and Safety of Orlistat for Type 1 Hyperlipoproteinemia

Type 1 Hyperlipoprotenemia

Type I hyperlipoproteinemia (T1HLP, also known as familial chylomicronemia syndrome or FCS) is a rare diseasewhere the blood triglycerides (fats) are very high. It is caused by lack of certain enzymes and proteins in the bodythat are important in disposing circulating fats from blood. Treatment of T1HLP patients who have very high levels of blood fats (≥ 1,000 mg/dL) is challenging as conventional triglyceride-lowering medications, such as fibrates and fishoil, are ineffective. The purpose of this trial is to study the long-term efficacy and safety of orlistat for reducing blood triglyceride levels in patients with T1HLP.

Not yet recruiting22 enrollment criteria

Effects of Non-surgical Periodontal Therapy on Severe Periodontitis and Hyperlipidemia

Periodontitis Chronic Generalized SevereHyperlipidemia4 more

This study was a single-center, non-randomized, parallel-group design clinical trial, and each group was assigned a 1:1 ratio with or without hyperlipidemia. Both groups underwent periodontal non-surgical treatment, and blood and gingival crevicular fluid were collected before surgery, 1 month and 3 months after surgery for the detection of MCP-1, IL-8, oxLDL, TNF-α, TG, LDL-C, HDL-C.

Recruiting8 enrollment criteria

Lipid Profile as Predictor of Adverse Maternal and Neonatal Outcomes: A Pilot Study

HyperlipidemiaPregnancy

The purpose of this study is to ascertain lipid profiles during pregnancy, specifically during the 24-28 week gestation and again near term at 36 weeks gestation. The research team are investigating whether lipid profiles can predict adverse maternal and neonatal outcomes.

Recruiting9 enrollment criteria

Imaging the Pathogenesis of Cerebral Small Vessel Disease

Ischemic StrokeHypertension2 more

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Recruiting4 enrollment criteria

Bempedoic Acid Pregnancy Surveillance Program

PregnancyHyperlipidemias

Bempedoic acid pregnancy surveillance program

Recruiting1 enrollment criteria
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