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Active clinical trials for "Hypertension, Pulmonary"

Results 171-180 of 944

New Orleans Pulmonary Hypertension Biobank

Pulmonary HypertensionSystemic Sclerosis3 more

Pulmonary hypertension (PH) is a serious condition characterized by a mean pulmonary artery pressure >=25mmHg on right heart catheterization (RHC). Despite advances in PH care, outcomes are still sub-optimal and further research is required into the pathobiology of the disease and development of biomarkers that can guide clinical care. The investigators are establishing a biobank to collect samples (blood, urine, stool) from patients with pulmonary hypertension, patients at high risk for pulmonary hypertension, healthy controls, and patients undergoing right heart catheterization. Specimens will be stored for future investigations.

Recruiting9 enrollment criteria

Inflammatory Profiling in Chronic Lung Disease

Pulmonary Hypertension

The aim of this study is to investigate the underlying inflammatory profile in patients with chronic lung disease and determine the association pulmonary hypertension.

Recruiting4 enrollment criteria

Right Atrial Fibrosis in Pulmonary Hypertension

Pulmonary HypertensionChronic Thromboembolic Pulmonary Hypertension1 more

The study aim to assess right atrial (RA) remodeling, in terms of RA fibrosis, in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients. This will be investigated in detail with in-depth cardiac magnet resonance imaging (CMRI). A cohort with exclusion of pulmonary hypertension which underwent CMRI due to dyspnoe of unkown reason will be the control group.

Recruiting21 enrollment criteria

Arrhythmias in Pulmonary Hypertension Assessed by Continuous Long-term Cardiac Monitoring

Pulmonary HypertensionArrhythmias2 more

Arrhythmias are considered a prominent phenomenon in pulmonary hypertension (PH) as the disease progresses. According primarily to retrospective studies with up to 24 hours of monitoring, supraventricular tachycardias (SVT) can be found in 8-35% of patients, with significant impact on survival. Furthermore, a few prospective studies to date deploying short-term monitoring (10 minutes-24 hours) have revealed lower heart rate variability (HRV) in patients with pulmonary arterial hypertension (PAH). In ASPIRE arrhythmias and heart rate variability is being assessed via long term monitoring.

Recruiting19 enrollment criteria

Giessen Pulmonary Hypertension Registry and Biobank

Pulmonary Hypertension

Giessen Pulmonary Hypertension Registry and Biobank

Recruiting2 enrollment criteria

COMPERA / COMPERA-KIDS

Pulmonary Arterial Hypertension (PAH)Pulmonary Hypertension (PH)

In view of the manifold options for mono- and combination therapy that have now emerged for patients with pulmonary (arterial) hypertension (PH/PAH), controlled clinical trials can only provide part of the information needed for optimal management. In order to gather adequate data on PAH/PH treatment in routine clinical care, the ongoing COMPERA registry prospectively documents consecutive patients with newly initiated treatment of PAH/PAH since May 2007. The internet-based registry fulfills high quality standards through several measures (planned minimum centre contribution of at least 10 patients per year, automated plausibility checks of data at entry, queries, monitoring with source data verification in >50% of participating centers). It can be applied, among further purposes, for quality assurance: individual centers can confidentially compare their results with the combined outcome of other centers and the recommendations from guidelines. It is expected that the register contributes to optimization of specific drug therapy for PAH and PH. Since July 2013, also children of any age can be documented (COMPERA-KIDS).

Recruiting13 enrollment criteria

Pulmonary Hypertension in Left Heart Disease

Pulmonary HypertensionPulmonary Vascular Disease1 more

The goal is to compare patients with and without varying severity of pulmonary vascular disease based upon hemodynamic signatures, echocardiographic measures, and lung ultrasound, in tandem with expired gas metabolic testing and blood sampling.

Recruiting22 enrollment criteria

Activity Monitoring in Pulmonary Hypertension

Pulmonary Hypertension

This is a prospective, longitudinal, observational study of free-living activity trackers and patient reported outcomes to test the hypothesis that daily activity will have stronger prognostic value than 6MWD in patients with pulmonary hypertension after 12 weeks.

Recruiting5 enrollment criteria

Inflammatory Biomarkers of Pediatric Pulmonary Hypertension

HypertensionPulmonary

To investigate if the inflammatory protein, high mobility group box 1 (HMGB1), along with other inflammatory mediators, is elevated in pediatric patients with congenital heart disease (CHD) and pulmonary hypertension as compared to those with CHD alone, or with healthy controls.

Recruiting6 enrollment criteria

Identification of Heritable CTEPH

Chronic Thromboembolic Pulmonary Hypertension

Some patients who have blood clots come down with a life-threatening condition known as Chronic Thromboembolic Pulmonary Hypertension (CTEPH), which is high blood pressure only in the arteries of the lungs. This study seeks to understand more about the genetics causes of CTEPH by obtaining blood samples and examining family histories.

Recruiting13 enrollment criteria
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