Study of Rasburicase as Treatment or Prevention of Hyperuricemia Associated With Tumor Lysis Syndrome...
TumorsHyperuricemia1 moreThis is an open-label, multi-center study with 2 arms. The primary objective is to assess the response to treatment with rasburicase in 2 populations of adult and pediatric patients with lymphoma/leukemia/solid tumor malignancies, those previously treated with a uricolytic agent, and those not previously treated with a uricolytic agent at their first relapse or refractory disease.
Rasburicase Versus Allopurinol in Tumor Patients at Risk for Hyperuricemia and Tumor Lysis Syndrome...
Tumor Lysis SyndromeCancer1 moreThis is a randomized, multi-center, open-label, parallel group study with three arms: Rasburicase alone Rasburicase followed by Allopurinol Allopurinol alone The primary objective is to compare the adequacy of control of plasma uric acid concentration and the safety profile among the three arms.
The Role Of Fructose and Uric Acid In the Development of Obesity and Metabolic Syndrome
Overweight and ObesityMetabolic Syndrome1 moreThe purpose of this study is to determine if a low fructose intake could have an impact on weight loss, uric acid levels and the components of the metabolic syndrome (glucose, cholesterol, triglycerides, insulin resistance, high blood pressure).
Patients With Asymptomatic Hyperuricemia Have Stronger Local Inflammatory Response and Worse Outcome...
Arthritis KneeWe identify all patients who had undergone primary total knee arthroplsty(TKA) from April 1, 2015, to March 30, 2016. Patients are grouped by uric acid level. The knee society score(KSS score) and the hospital for special surgery knee score (HSS score) before the surgery and 6 years after the surgery will be collected. Also the clinical data will be collected.
Assocaiton Between Uric Acid Trajecteries and Remission of NAFLD in NAFLD Individuals
Non-Alcoholic Fatty Liver DiseaseHyperuricemiaUric acid is the end product of dietary or endogenous purines degradation, and hyperuricemia is one of the most common metabolic disorders. A growing body of evidence, comprising a great deal of cross-sectional studies and several prospective ones, also indicates that hyperuricemia is associated with increased prevalence, incidence, and disease severity of non-alcoholic fatty liver disease (NAFLD). Capitalizing on a cohort study in China, the investigators are aimed to assess the associations of SUA trajecteries with remission of NAFLD in NAFLD individuals and examined whether the association differs across subpopulations.
Study of FYU-981 in Hyperuricemia (Effect on Two Hyperuricemic Types)
HyperuricemiaTo investigate the pharmacodynamics, pharmacokinetics and safety of 7-day-repeated doses of FYU-981 administered orally to male hyperuricemic patients with uric acid-overproduction or uric acid-underexcretion type. In addition, to investigate the additive effects of the combination of FYU-981 and topiroxostat administered orally to male hyperuricemic patients with uric acid-overproduction type.
Effect of Reducing Uric Acid on Insulin Sensitivity and Oxidative Status
ObesityMetabolic Syndrome1 moreThe purpose of this study is to learn more about what is the effect of uric acid on oxidative stress and on the way the body metabolizes sugar in obese people. Understanding this may lead to better diseases such as diabetes.
Effect of Quercetin Supplements on Healthy Males: a Four-Week Randomized Cross-Over Trial
HyperuricemiaGout3 moreThe purpose of this study was to test the effect of chronic consumption of Quercetin 500 mg tablets on blood uric acid and other biomarkers in adult males.
A PD/Safety Study of RDEA3170 in Combination With Febuxostat for Treating Gout or Asymptomatic Hyperuricemia...
Gout and Asymptomatic HyperuricemiaThe purpose of this study is to explore the pharmacodynamics (PD), pharmacokinetics (PK), safety, and tolerability of multiple doses of RDEA3170 administered in combination with febuxostat compared to RDEA3170 administered alone and febuxostat administered alone in Japanese adult male subjects with gout or asymptomatic hyperuricemia.
Multiple Doses Study of SHR4640 in Male Subjects With High Serum Uric Acid Level
GoutHyperuricemiaThis is a single-Center, randomized, double-Blind, placebo-controlled, multiple ascending-dose Phase I trail.