Obesity-hypoventilation in Metabolic Syndrom Patients
Metabolic SyndromeObesity Hypoventilation Syndrome1 moreThe purpose of the study is to determined the prevalence of obesity-hypoventilation syndrome in patients with metabolic syndrom.
Prevalence of Rest Dyspnea and Impact of Non Invasive Ventilation on Breathing Sensations in CCHS...
CCHSCongenital Central Hypoventilation Syndrome1 moreCongenital central hypoventilation syndrome (CCHS) is a neuro-respiratory disease characterized by lifethreatening sleep-related hypoventilation involving an alteration of CO2/H+ chemosensitivity. This suggests cortical activity during awakening to maintain breathing. Cortical activity to keep breathing is usually associated with breathing discomfort ; this is the case in healthy subjects under non invasive ventilation (NIV) or with expiratory charge as well as in patients with amyotrophic lateral sclerosis. This can suggest that CCHS may be breathless at rest and this discomfort could be reduced by NIV. The objective is to evaluate dyspnea with a multi dimensional score, MDP, in CCHS patient at rest in every day life and during 1H session of NIV. The investigators will perform a prospective, including 20 CCHS patients. MDP scores will be measure before and after 1H-non invasive ventilation as well as a visual scale of 100mm in order to evaluate variation of breathing discomfort before/after NIV. The investigators expect that CCHS patients don't have rest dyspnea but NIV would improve breathing discomfort that would mean they have latent rest dyspnea.
Factors Associated With Hypoventilation in the Myotonic Dystrophy, Progressive Profile Over 5 Years...
Myotonic DystrophySteinertThe aim of this study is to determine the factors associated with alveolar hypoventilation in terms of cognitive impairment, daytime sleepiness, respiratory function, nocturnal respiratory events This evaluation will clarify the clinical phenotypes of respiratory disease in myotonic steinert dystrophy.
Development of an Algorithm That Predicts Hypoventilation Due to an Opioid Overdose
Drug OverdoseOpioid-Related DisordersRTM Vital Signs, LLC is developing a miniature wearable tracheal sound sensor that communicates with a cell phone containing a machine-learning diagnostic algorithm designed to detect and predict the onset of mild, moderate, and severe hypoventilation (respiratory depression) due to an opioid overdose. The purpose of this clinical trial is to develop/validate diagnostic algorithms capable of detecting/predicting the onset of hypoventilation induced by a controlled intravenous infusion of fentanyl. The wearable sensor and algorithms will provide a series of alerts and alarms to the person, caregiver, and/or emergency personnel.
Rescue High Frequency Oscillatory Ventilation in Newborns Who Do Not Respond to Conventional Ventilation...
Acute Mechanical Ventilatory FailureAlthough High Frequency Oscillatory Ventilation (HFOV) has been used in case of unresponsive to conventional mechanical ventilation both in children and newborns, there is no data on its success and the factors that affect its success in the literature.
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Obesity
Overweight and ObesityOverweight or Obesity10 moreThis study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding obesity.
Non-Invasive Monitoring of Respiratory Function in Spontaneously Breathing Patients With COVID-19...
Respiratory FailureVentilatory Failure4 moreThis study uses the AirGo band to monitor changes in tidal ventilation in spontaneously breathing patients with COVID-19 associated respiratory failure. It aims to recognize patterns of ventilation associated with worsening respiratory failure in this patient population. If successful, this study will lead to the development of new robust methods for real-time, continuous monitoring of respiratory function in patients with respiratory failure. In turn, such monitoring methods may enable improvements in the medical management of respiratory failure and timing of interventions.
PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations...
Central Alveolar Hypoventilation SyndromeDetect the PHOX2B Mutation-confirmed congenital central hypoventilation syndrome