Study on the Efficacy and Safety of Gelaspan
HypovolemiaIt is the objective of the study to investigate the efficacy and safety of two different volume replacement regimens with gelatine solutions.
Digital Ischemia Reduction in Critically Ill Patients
Hypovolemic ShockCardiogenic Shock1 morePatients requiring high dose pressors (minimum 2) who are unlikely to be weaned off them over 1 day will be identified. Patients will have the device applied to one hand while expectant medical management will continue to the contralateral hand.
Perioperative Fluid Therapy Optimization in Spinal Surgery
HypovolemiaHypervolemiaThe decision to give fluids perioperatively could be based on methods used to identify preload responsiveness, either invasive or noninvasive estimates of stroke volume variation during mechanical ventilation. This study compares fluid management using continuous noninvasive cardiac output measurement with standard perioperative fluid management.
Comparison of the Effects of an Hypertonic Solution With Ringer Lactate on Right Ventricular Function...
Right Ventricular Impaired FunctionHypovolemiaThis study is a phase III, randomized, controled, parallel groups, single blinded, clinical trial that aims at comparing the improvement of right ventricular function after administration of a hypertonic solution versus Ringer Lactate following cardiac surgery. Adults patients admitted to Grenoble University Hospital for elective cardiac surgery under cardiopulmonary bypass, in sinus rhythm and with Swan Ganz monitoring will be included. Patients needing fluid expansion in the first three hours after surgery will be randomized in two groups : one receiving Ringer Lactate (10 mL/kg), the other receiving hypertonic saline solution (3 mL/kg). Right ventricular function measured with Swan Ganz catheter, 30 minutes after fluid expansion will be the primary outcome.
Esophageal Echo Assessment of LV Function During Acute Normovolemic Hemodilution Using Crystalloid...
Acute HypovolemiaThe purpose of this study is to examine how the heart functions when a calculated amount of blood is removed and how two fluids, Lactated Ringer's (considered the standard replacement fluid) and Hypertonic Saline, re-expand the vascular system.
Vasodilator-induced Hypovolemia in Living Liver Donors
CVP and SVV During Living Donor HepatectomySurgical Field Grade (Condition of Surgical Field; Bleeding1 moreInduced hypovolemia is known to improve surgical field during living donor hepatectomy. This procedure is conventionally guided by monitoring the central venous pressure (CVP). Stroke volume variation (SVV) is a novel method to substitute with CVP to monitor cardiac preload. The investigators try to evaluate the relationship between CVP and SVV during CVP-guided vasodilator induced hypovolemia (validation study). Then, feasibility of vasodilator induced hypovolemia using the SVV calculated from the validation study will be tested (feasibility study).
The Impact of Focused Transthoracic Echocardiography in Urgent Abdominal Surgery for Septic Patients...
SepsisHypovolemia1 moreThe aim of the study is to identify the diagnostic value of the focused assessed echocardiography in septic patients undergoing urgent abdominal surgery due to peritonitis. The investigators expect that the incidence of hemodynamic instability will be reduced and the survival of the patients will be improved.
Preoperative Volume Substitution in Elective Surgery Patients
Hemodynamic InstabilityHypovolemia1 morePreoperative fasting can evoke a hypovolemia which may cause a hemodynamic instability during introduction of anesthesia. The purpose of this study is to test the hypothesis that a defined preoperative volume substitution compared to standard procedure will result in a reduced incidence of hemodynamic instabilities during introduction of anesthesia in elective surgery patients.
Impact of Early Goal-directed Fluid Therapy in Hypovolemic Patients Undergoing Emergency Surgery...
Hypovolemic ShockTrauma2 moreThis study compares the safety and efficacy of GDTs using standard pressure-related parameters vs. dynamic hemodynamic indices associated with fluid compartment monitoring, in trauma patients requiring emergency surgery.
Intraoperative Hypovolemia and Fluid Therapy
HypovolemiaOrgan DysfunctionPostoperative organ dysfunction severely affects the prognosis of surgical patients. Despite several trials evaluating restrictive or liberal fluid strategies, the ideal fluid replacement strategy remains controversial. Owing to the risk of altered tissue perfusion, a key trigger of organ dysfunction, the purpose of this study was to compare the influence of restrictive and liberal fluid regimens, using a goal-directed approach, on hypovolemia and postoperative organ dysfunction.