SCI Acute Intermittent Hypoxia and Non-Invasive Spinal Stimulation Combined With Gait Training
Spinal Cord InjuriesSpinal Cord DiseasesThis is a single blind, sham controlled crossover trial that will evaluate the effectiveness of acute intermittent hypoxia therapy (AIH) combined with transcutaneous (non-invasive) spinal cord stimulation on gait and balance function for individuals after spinal cord injury.
Citicoline as Neuroprotector in Neonates Exposed to Hypoxia
Neonatal HypoxiaCiticoline as neuroprotector in neonates exposed to hypoxia: A randomized controlled trial
HYPoxaEmic Respiratory Failure and Awake Prone Ventilation
Respiratory FailureHypoxemiaThe goal of this prospective multi-centre randomised controlled trial is to determine if addition of awake prone positioning to standard oxygen, high flow oxygen therapy and non-invasive ventilation may reduce the rates of endotracheal intubation and mechanical ventilation.
Intermittent Hypoxia Paired With High Intensity Training in Brain Injury
Brain InjuriesThe central hypotheses are that HIT combined with AIH results in: 1) greater locomotor gains as compared to HIT alone; 2) improvements in gait quality and motor coordination during walking, and 3) changes in measures of community participation and integration.
Normobaric Hyperoxia Combined With Endovascular Therapy in Patients With Stroke Within 6 Hours of...
StrokeAcute3 moreThe overall incidence of good outcome for AIS following endovascular treatment is only proximately 50%. Whether NBO was safe and effective to improve acute ischemic stroke prognosis is still unclear. The investigators' hypothesis is thatNBO is a safe and effective strategy to improve longterm outcome in AIS patients undergoing endovascular treatment.
Oxygen Savings With Administered Oxygen and High Flow Ambient Air At Rest
Pulmonary DiseaseChronic Obstructive6 moreThis study is meant to compare the amount of oxygen required for hypoxemia relief between current standard of care (oxygen only) and oxygen with the addition of high flow air for Chronic Obstructive Pulmonary Disease (COPD), Interstitial Lung Disease (ILD), and Pulmonary Hypertension (PH) patients during rest. Subjects will be titrated from 0 L/min until they maintain 95% SpO2 for each of the following delivery methods: Pulses of pure oxygen (control) Constant high flow air with pulses of pure oxygen Out of phase pulses of high flow air and pure oxygen
The Effect of Oxygen Therapy on 6MWD in PAH and CTEPH Patients With Hypoxemia
Oxygen DeficiencyPulmonary Arterial Hypertension1 moreTreatment of O2 naïve patients with PAH will be included in this investigator-initiated trial (IIT) to assess efficacy and safety of oxygen substitution. Nocturnal oxygen substitution improved the 6MWD compared to placebo in one clinical trial in PAH patients. Due to the positive results in the treatment of patients with PAH, the initiation of this proof-of-concept study is justified.
Influence of Cooling Duration on Efficacy in Cardiac Arrest Patients
Cardiac ArrestOut-Of-Hospital4 moreA multicenter, randomized, adaptive allocation clinical trial to determine if increasing durations of induced hypothermia are associated with an increasing rate of good neurological outcomes and to identify the optimal duration of induced hypothermia for neuroprotection in comatose survivors of cardiac arrest.
Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior...
Congenital Heart Disease in ChildrenHypoxia2 moreDetermine 1) the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay (ND) outcomes and 2) how this relationship is modified by patient and environmental factors such as chronic congenital heart disease (CCHD) lesion, maternal-fetal environment, and social determinants of heath (SDOH) in a diverse population using a multicenter design. Pregnant women will be approached during one of their fetal cardiology clinic visits.
Motor Plasticity, Intermittent Hypoxia and Sleep Apnea
Sleep ApneaObstructive2 moreThe purpose of this study is to learn about the effect of sleep apnea and low oxygen on muscle strength and lung function in people with chronic spinal cord injury.