search

Active clinical trials for "Parkinson Disease"

Results 241-250 of 3533

Usability of a Novel Cueing Device for Patients With Parkinson's Disease

Freezing of GaitParkinson Disease

Hypokinetic gait disorder and Freezing of Gait (FOG) are frequent symptoms in the advanced stage of Parkinson's disease (PD). These impair quality of life and significantly increase the risk of falls. External movement pacemakers have been developed to improve gait and avert FOG by cueing strategies. The investigators developed a smart, small and lightweight, easy-to-handle wearable tactile cueing device (TCD), consisting of a control unit, two pulse generators and a battery-driven power supply. The device is programmed via a Graphical User Interface (GUI).

Recruiting8 enrollment criteria

Closed Loop Programming Evaluation Using External Responses for Deep Brain Stimulation

Parkinson Disease

The objective of this study is to evaluate the performance of novel DBS programming methods compared to traditional programming methods.

Recruiting5 enrollment criteria

Innovative Models in the Rehabilitation of the Elderly With Parkinson's Disease Through Technological...

Parkinson DiseaseFrail Elderly1 more

The final goal of the present study is to propose a new approach in the Parkinson's Disease rehabilitation, focused on the use of robotic devices and to check the results not only at the end of the treatment but also in the long term, foreseeing 3 follow-up.

Recruiting14 enrollment criteria

Neuromodulation of Sleep Architecture by STN-DBS in Parkinsonian Patients

Parkinson DiseaseSleep Disorder

Sleep disorder is one of the most burdensome non-motor symptoms in Parkinsonian patients. Typical manifestations include RBD, decreased sleep efficiency, decreased slow wave sleep, daytime sleepiness, increased sleep latency and wakefulness during sleep. Subthalamic nucleus (STN) deep brain stimulation (DBS) has been reported to improve sleep dysfunction in several studies, mostly due to its improvement in motor dysfunction. However, there are limited research about specific STN-DBS stimulation pattern for sleep architecture regulation, and whether suboptimal parameter combinations for motor has potential benefits for sleep improvement has not been studied. Here we use different parameter combination in STN-DBS, especially by changing stimulation contact and frequency, to explore the specific stimulation pattern for normalizing sleep architecture and increasing slow wave sleep.

Recruiting11 enrollment criteria

Sensor-based Assessment and Rehabilitation of Balance in Neurological Diseases

StrokeMultiple Sclerosis1 more

Balance impairment is one of the most common disorders due to a neurological diseases. Sensor-based technologies may be useful for falls prevention and balance recovery during patients hospitalization. OAK Elderly Care System (Khymeia Group, Noventa Padovana, Italy) allows the assessment of fall risk, the centre of pressure and the execution of balance exercises in a virtual environment.

Recruiting23 enrollment criteria

Monocentric, Prospective Study to Assess the Pharmacokinetic Profile of Continuous and Diurnal Subcutaneous...

Parkinson Disease

This monocentric and prospective trial aims firstly to assess the pharmacokinetic profile of continuous and diurnal subcutaneous apomorphine infusion in patients with Parkinson's disease under stabilized treatment and, secondly, to collect data highlighting the possible influence of pharmacogenetics.

Recruiting13 enrollment criteria

Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Tributyrin Supplementation

Parkinson Disease

Small exploratory open-label pilot study to assess the short-chain fatty acid (SCFA) prodrug tributyrin as a potential therapy for persons with Parkinson disease

Recruiting11 enrollment criteria

Physical Training for People With Parkinson's Disease and Multiple Sclerosis: Effect on Mind and...

Parkinson DiseaseMultiple Sclerosis

People with Parkinson's disease and Multiple Sclerosis experience disabling motor and non-motor symptoms, which respond insufficiently to medication. To adequately alleviate disease burden, physical training is increasing acknowledged as an assisting therapy; however, the optimal dose of exercise in unknown.

Recruiting11 enrollment criteria

Brain Small Chain Fatty Acid Metabolism in Parkinson Disease: Ketones

Parkinson DiseaseLewy Body Dementia1 more

Small exploratory open-label pilot study to assess supplementation of a ketone ester (KetoneAid) as a potential therapy for persons with Parkinson disease (PD), Parkinson Disease Dementia/Lewy Body Dementia (PDD/LBD), and healthy controls.

Recruiting12 enrollment criteria

Effects of Exercise Training and Ketone Ester on Muscle Strength and Cardiovascular Response in...

Parkinson Disease

The main purpose of this study is to assess changes in exercise capacity in people with Parkinson's disease before and after an exercise training program with ketone ester supplementation.

Recruiting11 enrollment criteria
1...242526...354

Need Help? Contact our team!


We'll reach out to this number within 24 hrs