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Active clinical trials for "Purpura, Thrombocytopenic, Idiopathic"

Results 61-70 of 380

Contribution of Anti-platelet Antibodies Identified With MAIPA Assay in the Demonstration of the...

ThrombocytopeniaImmune Thrombocytopenia1 more

Immune thrombocytopenia (ITP) is an autoimmune disease but, paradoxically, and unlike other autoimmune diseases, antiplatelet antibodies are not used either for the diagnosis of the disease or for its prognosis. ITP is a diagnosis of exclusion retained after elimination of other pathologies leading to a thrombocytopenia. No major study has prospectively evaluated the diagnostic value of the presence of anti-platelet antibodies in the etiological investigation of a thrombocytopenia, nor the impact of platelet antibodies on the course of ITP. The gold standard analysis for the determination of platelet antibodies, is the "monoclonal antibody immobilization of platelet antigens" assay (MAIPA), either direct to detect autoantibodies attached to platelets, or indirect to detect circulating antiplatelet antibodies. Therefore, this work aims to study the contribution of the presence of anti-platelet antibodies detected in MAIPA to determine the autoimmune nature of a thrombocytopenia at diagnosis.

Recruiting13 enrollment criteria

Efficacy and Safety of Iguratimod in the Treatment of Steroid-resistant/Relapse Immune Thrombocytopenia...

Immune Thrombocytopenia

A phase 2, open-label, single-arm study to evaluate the efficacy and safety of iguratimod for the treatment of adults with steroid-resistant/relapse immune thrombocytopenia (ITP)

Not yet recruiting12 enrollment criteria

A Prospective, One-arm and Open Clinical Study of Obinutuzumab in the Treatment of Pediatric Primary...

Immune ThrombocytopeniaTreatment

To evaluate the safety and efficacy of Obinutuzumab in the treatment of pediatric primary immune thrombocytopenia in patients who have not responded adequately or relapsed after first-line glucocorticoid treatment.

Not yet recruiting24 enrollment criteria

The Combination of Zanubrutinib and High-dose Dexamethasone as First-line Treatment in Adult Immune...

Immune Thrombocytopenia

Randomized, open-label, multicenter study to compare the efficacy and safety of zanubrutinib plus high-dose dexamethasone compared to high-dose dexamethasone monotherapy for the first-line treatment of adults with primary immune thrombocytopenia (ITP).

Not yet recruiting12 enrollment criteria

Investigation on a Dynamic Cohort of Italian Patients With Active ITP

Idiopathic Thrombocytopenic Purpura

The objective of the study is to produce a dynamic picture of the adult ITP natural history and management in Italy by collecting standardized information retrospective and prospective data of patients in active management through a nation-wide registry.

Recruiting4 enrollment criteria

A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP

Immune ThrombocytopeniaBruton's Tyrosine Kinase

BTK participates in a variety of signal transduction of innate and adaptive immunity, and has an important role in cell proliferation, differentiation and apoptosis. The impact of BTK inhibitors on hematological malignancies and autoimmune diseases has been well studied. This project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of the selective BTK inhibitor Orelabrutinib in the management of refractory ITP.

Not yet recruiting23 enrollment criteria

Extension Study of Herombopag for Pediatric Patients With Chronic Immune Thrombocytopenia

Immune Thrombocytopenia

The main purpose of this extended study is to enable subjects who are currently receiving the PartB experimental drug in the HR-TPO-ITP-III-PED clinical trial .To continue receiving the experimental drug after the completion of the clinical trial if they benefit from the treatment at the end of the clinical trial.Until the study physician determines that the subject has failed treatment or that the subject can no longer benefit from treatment or extends the study treatment for 6 months.In addition, the secondary purpose of this extended study was to observe the long-term efficacy and safety of tripodal in children and adolescents.

Not yet recruiting10 enrollment criteria

Combined Steroid and Cyclosporin as First-line Treatment in Adults With Primary Immune Thrombocytopenia...

Immune Thrombocytopenia

Randomized, open-label, multicenter study to compare the efficacy and safety of cyclosporin plus standard steroid compared to standard steroid monotherapy for the first-line treatment of adults with primary immune thrombocytopenia (ITP).

Not yet recruiting10 enrollment criteria

The Combination of ATRA and Eltrombopag as the Treatment of Steroid-resistant/Relapse ITP Based...

PurpuraThrombocytopenic1 more

A Prospective, Randomized, Open-Label, Multicenter Clinical Trial study to compare the efficacy and safety of ATRA plus eltrombopag compared to eltrombopag monotherapy in the treatment of steroid-resistant/relapsed immune thrombocytopenia (ITP).

Not yet recruiting2 enrollment criteria

Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients With Chronic Primary Immune...

Chronic Primary Immune Thrombocytopenia (ITP)

A Randomized, Double-blind, Placebo-controlled Phase III Clinical Study to Evaluate the Efficacy and Safety of Orelabrutinib in Adult Patients with Chronic Primary Immune Thrombocytopenia

Not yet recruiting25 enrollment criteria
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