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Active clinical trials for "Immune System Diseases"

Results 81-90 of 184

Experimental Autologous Mesenchymal Stem Cell Therapy in Treatment of Chronic Autoimmune Urticaria...

UrticariaAutoimmune Diseases2 more

The aim of this study is to determine whether autologous adipose tissue derived Mesenchymal Stem Cells of treatment for chronic autoimmune urticaria is safe and effective.

Completed10 enrollment criteria

A Study of Subcutaneous KY1005 in Healthy Volunteers

Immune System Diseases

Single centre, open-label, single dose, parallel group study to investigate the PK, safety and tolerability of KY1005 after subcutaneous (s.c.) and intravenous (i.v.) administration, with i.v. KY1005 as a reference treatment.

Completed9 enrollment criteria

Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases

HTLV-1Tropical Spastic Paraparesis3 more

In this study the investigators are going to evaluate the efficacy pentoxifyline in HTLV-1 patients with neurological diseases: HAM/TSP or neurogenic bladder. In some laboratory experiments the investigators observed that this drug had the capacity to reduce the immune response in HTLV-1 infected cells. Since the exacerbated immune response is know to cause neurological disease in patients with HTLV-1 the investigators hope that pentoxifyline can alleviate symptoms and delay the progress of HAM/TSP in patients.

Completed10 enrollment criteria

Single Center Food Allergy Oral Immunotherapy Study

Immune System Diseases

The Primary Objective of the study is to develop a customized regimen for oral immunotherapy that reflects what the subject is allergic in a clinically significant way (i.e., the offending food allergen is defined as a food allergen with a positive skin test or positive specific IgE and a positive DBPCFC). Therefore, the investigators prefer that both single and multiple food allergy subjects are included in the study.

Completed4 enrollment criteria

Friendship Bench Adaptation to Improve Mental Health & HIV Care Engagement Outcomes Among PLWH and...

HIV InfectionsBehavioral Symptoms6 more

This project will adapt and pilot a feasible and effective problem-solving therapy designed for low-resource settings to address common mental disorders like depression and anxiety - the Friendship Bench- in a Vietnamese population of individuals living with HIV who also have opiate use disorder. The Friendship Bench approach has the potential to make an important contribution to address CMDs and reduce barriers to HIV treatment success among people living with HIV (PLWH) with Opioid Use Disorder (OUD), a critical population driving the HIV epidemic in Vietnam and many Southeast Asian countries. This proposal will generate critical evidence for designing a fully powered clinical trial to test the investigation team's adapted FB protocol in improving HIV, mental health, and drug use treatment outcomes for this vulnerable population.

Completed5 enrollment criteria

An Open-Label, FIH Study Evaluating the Safety and Tolerability of VCTX210A Combination Product...

Diabetes MellitusDiabetes Mellitus6 more

This is an open-label, multicenter, Phase 1 study evaluating the safety and tolerability of VCTX210A combination product in patients with T1D

Completed7 enrollment criteria

Immune Diversity Response to Oral Dosing of Nutritional Health Products in Healthy Participants...

Immunity Disorders

A Phase IV, open-label, adaptive, 4-arm, multi-dose, single-centre, exploratory trial to assess the immune diversity response to oral administration of licensed Natural Health Products, in healthy adults, 60-70 years of age.

Completed29 enrollment criteria

Polyphenols, Exercise, and Metabolomics

Exercise-induced InflammationExercise-induced Oxidative Stress1 more

Nutrasorb is a newly developed food product (see www.nutrasorb.com). This study will use the Nutrasorb soy protein product that is matrixed with polyphenols from blueberries and green tea extract, and test for efficacy as a nutritional countermeasure to exercise-induced physiologic stress (i.e., immune dysfunction, inflammation, and oxidative stress) using both traditional and metabolomics-based outcome measures.

Completed10 enrollment criteria

Efficacy and Safety of Dupilumab in Participants ≥12 to <18 Years of Age, With Moderate-to-severe...

Moderate-to-Severe Atopic DermatitisDermatitis16 more

The primary objective of the study was to demonstrate the efficacy of dupilumab as a monotherapy in participants ≥12 years to <18 years of age with moderate-to-severe atopic dermatitis (AD). The secondary objective of the study was to assess the safety of dupilumab as a monotherapy in participants ≥12 years to <18 years of age with moderate-to-severe AD.

Completed18 enrollment criteria

A Study of KY1005 in Healthy Volunteers

Immune System Diseases

This is a single and multiple ascending dose, placebo-controlled, double-blind, Phase 1 study to evaluate the safety and tolerability of KY1005 in healthy volunteers.

Completed30 enrollment criteria
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