Outcomes of Neonates Born to Mothers With SARS-CoV-2 Infection in Shanghai
SARS-CoV2 InfectionNeonatal Infection1 moreSince March 2022, there are an outbreak of SARS-CoV-2 infection (Omicron) in Shanghai. This cohort study aims to analysis the clinical outcomes of neonates born to mothers with SARS-CoV-2 infection.
Acceptability of HPV Self-sampling Among Canadian Women Aged 21 to 65
HPV InfectionCervical Cancer ScreeningWe propose a cross-sectional study to explore the acceptability and feasibility of HPV self-sampling among Quebec women. The study will invite eligible women to self-sample for HPV at home. The HPV risk factors of patients included in the study will be taken into consideration (vaccination, smoking, number of partners, date of last screening, etc.).
Active Screening of Latent Tuberculosis Infection in School Contacts of Active Tuberculosis Patients...
TuberculosisLatent Tuberculosis InfectionThe goal of this observational study is to investigate the proportion of Mycobacterium tuberculosis (MTB) infection in school contacts of active tuberculosis (ATB) patients. The main questions it aims to answer are: the proportion of MTB infection among school contacts of ATB patients risk factors related to tuberculosis (TB) infection health economic evaluation of screening strategy
Research About Impact of HPV Integration on the Prognosis of Women With Persistent HR-HPV Infection...
HPV InfectionLSIL4 moreClinically, patients with persistent HR-HPV infection for more than 18 months or HR-HPV infection with CIN2 + need regular colposcopic biopsy to assess the outcome and progression of the disease. A total of 1000 participants with persistent HR-HPV infection (100 cases/center) were recruited from multiple centers, and HPV integration status and vaginal flora diversity were sequenced at baseline, 6th month, 12th month and 24th month, respectively, through prospective cohort studies. And to evaluate the influence of HPV integration status and flora changes on the prognosis of women with persistent HR-HPV infection.
The Association of Gut Microbiota With COVID 19 Infection in Children
Coronavirus InfectionsGut Microbiome1 moreAlthough COVID-19 infects gastrointestinal tissues, little is known about the roles of gut commensal microbes in susceptibility to and severity of infection. The investigators will analyze the alterations in fecal microbiomes of patients with COVID-19 infection during hospitalization.
Evaluation of the Labcorp COVID-19+Flu+RSV Test Home Collection Kit
COVID-19 Respiratory InfectionInfluenza A2 moreTo compare the results obtained by analysis of a self-collected anterior nasal (AN) swab as part of the Labcorp COVID-19+Flu+RSV Test Home Collection Kit to a healthcare provider (HCP)-collected AN swab in patients with symptoms of viral respiratory infection consistent with influenza A (Flu A), influenza B (Flu B), respiratory syncytial virus (RSV) and/or SARS-CoV-2 (C-19).
Promotion and Application of a New Three-level Etiological Diagnosis Strategy for Fever Clinics...
Respiratory Infectious DiseasesRelying on fever clinics, this project evaluates the clinical diagnostic efficiency of the three-level pathogen diagnostic system, monitors changes in respiratory pathogens, and realizes real-time monitoring and early warning of acute respiratory infectious diseases in Shanghai.
Inflammatory and Infectious Diseases of the Nervous System
Brain DiseaseBackground: - Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this. Researchers want to learn more about how diseases affect the brain and nerves to develop better tests and treatments. Objective: - To learn more about how inflammation and infections hurt the brain and nervous system. Eligibility: - People at least 2 years old with a diagnosis or suspected diagnosis of nervous system infection or inflammation. Design: For some participants, a clinician outside of NIH will collect blood, tissue, and other samples. These will be sent to NIH and analyzed. Other participants will have several visits to NIH. Children may not have all these tests. Participants will have: Medical history. Physical and neurological exam. Blood and urine samples collected. Saliva collected. They will chew on a piece of sterile cotton for one minute. Magnetic resonance imaging (MRI) scan. The scanner is a metal cylinder in a strong magnetic field. Participants will lie on a table that slides in and out of the cylinder. Participants will get a contrast agent through an intravenous (IV) catheter during the MRI. A needle will be used to guide a thin plastic tube (catheter) into an arm vein. Lumbar puncture. Skin will be numbed and a needle will be inserted into the space between the bones in the back. Fluid will be removed. Some participants may have optional study procedures. These may include eye tests, memory and thinking testing, tests with electrodes on the head, or skin biopsy.
Non-Invasive Diagnosis of Pediatric Pulmonary Invasive Mold Infections
Pulmonary Invasive Fungal InfectionsPulmonary Invasive AspergillosisThis study will establish a non-invasive diagnostic approach and evaluate clinical outcomes for children at high-risk for pulmonary invasive fungal infection (PIFI).
Technology-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During...
Sexually Transmitted InfectionAlcohol Use Complicating the Puerperium3 moreThis proposed study is to test whether Health Check-up for Expectant Moms (HCEM), a computer-delivered screening and brief intervention (SBI) that simultaneously targets sexually transmitted infection (STI) risk and alcohol/drug use during pregnancy, reduces antenatal and postpartum risk more than an attention, time, and information matched control condition among pregnant women seeking prenatal care.