Oral Antibiotic Treatment at Home Instead of Intravenous Treatment in Hospital for Resistant Gram...
Gram-positive Bacterial InfectionsStaphylococcal InfectionsThe main purpose of this study is to find out whether changing the hospital policy to allow switch from glycopeptide antibiotics (given by intravenous drip), to an equally effective oral antibiotic (linezolid) will enable patients who are otherwise well enough to be discharged from hospital sooner. The secondary objectives are To identify those patients who could potentially be discharged on an oral agent from those being treated with a glycopeptide, thus helping target this approach most effectively To evaluate the cost involved and compare this with the costs that would have taken place if use of an oral agent and discharge had not occurred.
Valganciclovir to Reduce T Cell Activation in HIV Infection
HIV InfectionsCytomegalovirus InfectionsThe purpose of this study is to determine whether treatment with valganciclovir decreases T cell activation levels among HIV-infected patients with asymptomatic cytomegalovirus (CMV) co-infection, potentially improving immune responses to antiretroviral therapy.
Telithromycin in Respiratory Tract Infections
Respiratory Tract InfectionsPrimary Objectives: The primary objective of the study is to evaluate clinical efficacy i.e. to show that with respect to clinical cure rate, Ketek® (telithromycin) in the treatment of community acquired respiratory tract infections: community acquired pneumonia (CAP), acute bacterial exacerbation of chronic bronchitis (AECB) and acute sinusitis (AS), in outpatients. Secondary Objectives: The secondary objectives are to: Further assess the efficacy of Ketek® (telithromycin) by considering the rate at which additional antibacterials were prescribed to treat the primary infection; the rate of hospitalisation due to a complication of the primary infection and assessment of bacteriological data, chest X-ray and sinus X-ray if available. Evaluate safety of Ketek® (telithromycin) through Adverse Event (AE) and Serious Adverse Event (SAE) reporting
A Study of the Safety and Effectiveness of Oral Levofloxacin Compared With Oral Ciprofloxacin in...
Skin DiseasesInfectious1 moreThe purpose of this study is to evaluate the safety and effectiveness of levofloxacin, an antibiotic, compared with ciprofloxacin, another antibiotic, in the treatment of adults with mild to moderate infections of the skin and the supportive layers beneath the skin.
A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone...
Skin DiseasesBacterialThe purpose of this study is to compare the safety and effectiveness of levofloxacin (an antibiotic) with ticarcillin/clavulanate alone or followed by amoxicillin/clavulanate in the treatment of complicated skin infections.
Computerized Decision Support System for Antibiotic Treatment
Community-Acquired InfectionCross InfectionWe developed a computerized decision support system for prescription of antibiotics to inpatients. The purpose of the study is to assess the performance of the system in different wards, in three different hospitals, in three countries.
Study Comparing Tigecycline Versus Ceftriaxone Sodium Plus Metronidazole in Complicated Intra-abdominal...
AppendicitisCholecystitis4 moreThis is a study of the safety and efficacy of tigecycline to ceftriaxone sodium plus metronidazole in hospitalized subjects with cIAI. Subjects will be followed for efficacy through the test-of-cure assessment. Safety evaluations will occur through the treatment and post-treatment periods and continue through resolution or stability of the adverse event(s).
Evaluating the Effectiveness of the Acute Respiratory Infection Smart Form
Respiratory Tract InfectionsTo evaluate the effectiveness of the Acute Respiratory Infection Smart Form
Doripenem in the Treatment of Complicated Lower Urinary Tract Infection or Pyelonephritis
Urinary Tract InfectionsPyelonephritisThe purpose of this study is to compare the microbiological cure rate of doripenem versus a comparator antibiotic in the treatment of patients with complicated urinary tract infection or pyelonephritis. The study will also characterize the safety and tolerability of treatment with doripenem in patients with complicated urinary tract infection or pyelonephritis.
Doripenem in the Treatment of Complicated Intra-Abdominal Infections
Bacterial Infections and MycosesAppendicitis3 moreThe purpose of this study is to compare the clinical response rate of doripenem versus a comparator in the treatment of hospitalized patients with complicated intra-abdominal infections.