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Active clinical trials for "Infections"

Results 2991-3000 of 6584

KIVEXA Vs TRUVADA, Both Administered With Efavirenz, In ART-Naive Subjects

InfectionHuman Immunodeficiency Virus I1 more

Recently, the fixed-dose combinations (FDC) KIVEXA™ (abacavir/lamivudine) and TRUVADA (tenofovir disoproxil fumarate/emtricitabine) have facilitated the usage of once-daily regimens. However data from head-to-head randomized trials comparing these two FDCs as part of an initial regimen are not available at present. The long-term toxicity profiles of these regimens are of particular importance, as treatment of HIV is currently life-long and therefore, minimizing long-term toxicity and maximizing adherence and duration of regimen maintenance are critical therapy objectives. The primary endpoint is estimated glomerular filtration rate (GFR), as measured by the modified diet in renal disease (MDRD) equation, a validated estimate of renal function.

Completed33 enrollment criteria

Pharmacokinetics of Retapamulin in Pediatric Subjects With Uncomplicated Skin Infections.

Skin InfectionsBacterial

A study to evaluate the pharmacokinetics of Retapamulin Ointment, 1%, in pediatric subjects (2-24 months) with secondarily-infected traumatic lesions, secondarily-infected dermatoses, or impetigo (bullous and non-bullous).

Completed24 enrollment criteria

Effect of Maraviroc on Endothelial Function in HIV-Infected Patients

HIV InfectionCardiovascular Disease2 more

The purpose of this study is to determine the potentially beneficial aspects of CCR5 inhibition on inflammation and endothelial function as measured by brachial artery reactivity in antiretroviral treated HIV patients with an undetectable viral load.

Completed12 enrollment criteria

Nelfinavir and M8 Drug-level Monitoring in HIV-1 Infection

HIV Infections

The purpose of this study is to assess the impact of prospective drug level monitoring and dose-adjustment of nelfinavir (NFV) on the clinical and virologic outcomes in a group of HIV-infected patients who have achieved virologic success while receiving a nelfinavir containing highly active antiretroviral therapy (HAART) regimen.

Completed9 enrollment criteria

Chlorhexidine vs Povidone Iodine in Alcoholic Solutions for Prevention of Central Venous Catheter...

ICU Patients Requiring a Central Venous Access

The best antiseptic solution for cateheter care remains unknown.High concentration in aquous solution or low concentration in alcoholic solution of chlorhexidine actbetter than povidone iodine in aquous solutions. No study has compare alcoholic formulations of low concentration of chlorhexidine and povidone iodine for skin disinfection prior to insertion of central venous catheters. To compare the incidence of central venous catheter colonization after skin disinfection with either an alcoholic solution of povidone iodine or a combination of 0.5% chlorhexidine, 0.025% Benzalkonium and 4% benzylic alcohol. To compare the incidence of catheter related bacteremia in the to study groups. To compare the local and general tolerance of the two antiseptic formulations

Completed6 enrollment criteria

Study Comparing Tigecycline to Imipenem/Cilastatin in Complicated Intra-Abdominal Infections in...

Gram-Positive Bacterial InfectionsCross Infection

Purpose: To provide a mechanism for the emergency use of tigecycline in the appropriate clinical situations.

Completed6 enrollment criteria

A Study to Learn More About MAC Disease and the Use of Anti-HIV Drugs in Patients With Advanced...

Mycobacterium Avium-intracellulare InfectionHIV Infections

The purpose of this study is to determine if infection with Mycobacterium avium complex (MAC) occurs in other parts of the body before it is found in the blood. This study also evaluates the relationships between the amount of HIV in the blood, immune system functions, and the presence of MAC infection. HIV-positive patients are at risk for MAC infection because their immune systems have been weakened by HIV. It is hoped that aggressive treatment with anti-HIV drugs may improve their immune systems enough to prevent against MAC.

Completed11 enrollment criteria

A Study of Amphotericin B in the Treatment of Fungal Infections of the Mouth in HIV-Infected Patients...

CandidiasisOral1 more

To assess response and toxicity in patients with fluconazole-resistant oral candidiasis ( thrush ) when given initial induction with amphotericin B oral suspension. Experience with amphotericin B oral suspension for drug-sensitive thrush in HIV-infected patients is limited but encouraging.

Completed33 enrollment criteria

The Safety and Effectiveness of Ganciclovir Plus Interferon Beta in Preventing the Return of Cytomegalovirus...

Cytomegalovirus RetinitisHIV Infections

The use of ganciclovir (DHPG) in combination with interferon beta to prevent relapse of cytomegalovirus retinitis in patients with AIDS. While early clinical trials have shown that 30 mg/kg/week of DHPG is usually sufficient to delay or prevent relapse, neutropenia is a common dose-limiting problem in about 50 percent of patients. Since in vitro data have suggested that there is synergism between DHPG and interferon beta against cytomegalovirus, a reduced dose of DHPG in combination with a low dose of interferon beta may prevent relapse without causing neutropenia. If remission can be maintained with low-dose DHPG and interferon beta, maintenance therapy with a moderate dose of interferon beta alone will be evaluated in a subsequent protocol.

Completed5 enrollment criteria

Phase II Randomized Study of Physiologic Testosterone Replacement in Premenopausal, HIV-Positive...

HIV InfectionsCachexia

OBJECTIVES: I. Determine whether physiologic testosterone replacement can increase fat-free mass, therefore contributing to weight maintenance, improved muscle function, and quality of life in HIV-infected women. II. Examine the mechanism of testosterone-induced increase in fat-free mass.

Completed11 enrollment criteria
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