An Observational Study of the Use of Siltuximab (SYLVANT) in Patients Diagnosed With COVID-19 Infection...
Severe Acute Respiratory Syndrome (ARDS) Secondary to SARS-COV-2 InfectionThis observational study will collect data from patients treated with siltuximab program for treatment of SARS-CoV-2 infection complicated with serious respiratory complications. This observational study will group the patients into two cohorts receiving siltuximab.. Outcome of patients will be compared to a cohort of patients receiving standard treatment without siltuximab. The patients will be divided into 2 cohorts. Those contained in Cohort A were treated after the use of continuous positive airways pressure (CPAP) or non-invasive ventilation (NIV). Patients in Cohort B were treated after intubation
Prospective Observational Study to Evaluate a Possible Change in APS Antibody Profiles After COVID-19...
Antiphospholipid SyndromeCOVID-19 Infection1 moreProspective observational study to evaluate a possible change in APS antibody profiles after COVID-19 infection or vaccination
Observational Study With Mode of Action-Analysis of Cystorenal Cranberry Extract in Patients With...
Urinary Tract InfectionsThe main focus of this observational study is to analyze the possible effects of cranberry dietary supplements on the intestinal microbiota in women with recurrent uncomplicated urinary tract infections. In a secondary analysis the possible influence of the microbiota changes on the recurrence frequency in the follow-up should be analyzed.
Evaluation of the Efficacy of an inTerdialytic "Ethanol 40% v/v - enoxapaRin 1000 U/mL" Lock solutioN...
Tunnelled Hemodialysis Catheter InfectionThe purpose of this study is to assessed the efficacy of a combined solution of ethanol (4%) and low molecular weight heparins LMWH in preventing tunnelled dialysis catheter infection in chronic hemodialysis patients
A Rapid Test for Acute Respiratory Illness
Respiratory Tract Infection AcuteTranscriptome2 moreThe primary purpose of this study is to support the development of a host response test for acute respiratory illness to identify bacterial, viral or NB/NV etiologies as compared to a clinical adjudication reference standard. Secondary objectives include: Evaluate the effect of age on the performance of the HR-ARI test Evaluate the effect of race/ethnicity on the performance of the HR-ARI test Evaluate the effect of geography on the performance of the HR-ARI test
Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study
Necrotizing Soft Tissue InfectionNecrotizing Fascitis2 moreThe investigators will analyze biomarkers related to the prognosis and treatment of necrotizing soft tissue infections (NSTI). The focus will be on whether certain endothelial and immune system biomarkers can function as markers of disease severity, mortality as well as the effects of hyperbaric oxygen therapy (HBOT). Biomarkers will be measured upon admission to an intensive care unit at Copenhagen University Hospital and during the following 3 days.
Dual Algorithm Post Market Clinical Study
HTLV-I InfectionsHTLV-II Infections4 moreThe purpose of this study is to assess the validity and reproducibility of the MP Diagnostics HTLV Blot 2.4 in blood specimens testing repeat reactive (RR) on the first FDA licensed screening assay (Abbott Prism) and non-reactive (NR) on the second FDA licensed screening assay (Avioq ELISA).
Controlled Crossover Study of AIONX Antimicrobial Surface for the Prevention of Healthcare-associated...
Healthcare Associated InfectionThis is a controlled open label efficacy study of Aionx antimicrobial surface for the prevention of healthcare-associated infections.
The Effect of a Local Injection of a Platelet Concentrate on Infection and Healing of Surgical Wounds...
Wound Infection and Wound HealingThe purpose of this project is to investigate whether a combination of a local injection of platelet rich plasma (PRP) combined with a daily supplement of vitamin C, zinc, L-arginine, as well as high protein diet (1.5 g of protein per kilo body weight per day) can promote tissue healing in patients undergoing open upper-abdominal surgery. Primary endpoint is cases of wound infection and secondary endpoints are time of tissue regeneration (days), judged by traditional clinical observation and experimentally assessed by ultrasound. The experiment is performed as a parallel two-armed, randomized, controlled trial. A total of 40 subjects will be included in the trial i order to ensure the power of the study, despite a drop off of up to 25%.
UNiD 3D VBR Register
Spinal Cord CompressionSpondylosis4 moreMulticenter study allowing to include the first sixty patients implanted with a custom-made corpectomy implant (UNiD 3D VBR): 30 patient implanted in cervical region and 30 patients implanted in thoracolumbar region. The main objective is to confirm feasibilty and safety of patient-specific implants for one or multi-level corpectomy and fusion. This study was approved in March 2016 allowing to include retrospectivley all patients since the first implantation in January 2015 and prospectively all patients after the approval.