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Active clinical trials for "Infertility, Male"

Results 101-110 of 190

The Paleolithic Diet and Male Factor Infertility

Male Infertility

Prospective studies concerning diet and male fertility are lacking. Observational studies suggest that a diet rich in fruits, vegetables and meats may be associated with higher sperm counts. The investigators wanted to see if a "paleolithic diet" consisting of meat, fish, fruits vegetables and nuts and lacking grains, legumes and dairy products can improve sperm counts.

Withdrawn7 enrollment criteria

GnRH Agonist at Embryo Transfer: IVF Outcomes

InfertilityInfertility3 more

In ART (assisted reproductive technology) cycles, embryos are transferred to a woman's uterus after in-vitro fertilization (IVF) in a laboratory. Usually, hormones (progesterone) are given to the patient after transferring the embryo, as a supplement, in order to mimic the natural hormones that would normally be secreted in an unassisted pregnancy. This study will identify whether additional gonadotropin-releasing hormone (GnRH-agonist) administration, a natural hormone secreted from the hypothalamus, will improve the clinical pregnancy and live birth rates when using IVF.

Withdrawn2 enrollment criteria

Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation...

Cystic FibrosisCongenital Bilateral Absence of Vas Deferens2 more

The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal cells in patients with male infertility of any kind, or with cystic fibrosis or bilateral agenesis of the vas deferens, requiring scheduled surgery. The main questions it aims to answer are: to better characterise this 3D organisation of the CFTR locus, the study of regulatory elements in primary epididymal cells is the most relevant and realistic model. to gain a better understanding of the regulation of the CFTR gene in epididymal cells in order to gain a better understanding of the pathology of male infertility caused by bilateral agenesis of the vas deferens, a symptom and also a borderline form of cystic fibrosis. Participants will Epididymal samples will be taken by a urologist for the AMP department during the planned surgery. The rest of the samples taken will be recovered for research purposes, with the aim of recovering the epididymal cells contained in the sample. This is in no way an additional procedure and will have no impact on the patient's health..

Not yet recruiting7 enrollment criteria

Cell Free Preimplantation Genetic Testing

InfertilityFemale2 more

This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.

Not yet recruiting2 enrollment criteria

Effect of Ejaculatory Abstinence on Semen Parameters in Male Factor Infertility Patients

InfertilityMale

The purpose of this study is to compare semen parameters with in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) when male factor infertility patients abstain from ejaculation more than 48 hours (routine care) or less than 24 hours from the day of the partner's oocyte retrieval. The investigators hypothesize that total motile sperm count will be improved with ejaculatory abstinence (EA) less than 24 hours. Information from this trial could allow investigators to optimize chances for a successful pregnancy in patients who need IVF/ICSI.

Terminated12 enrollment criteria

Non-invasive Detection of Male Infertility With FDG-PET/MRI (Spectroscopy and DWI)

Fertility Disorders

The aim of the study is to examine the value of the new MRI techniques (spectroscopy and DWI), and FDG-PET in prognostication of male infertility.

Terminated2 enrollment criteria

BPA Levels Relationship With IVF/ICSI Outcomes in Patients With Male Factor

InfertilityMale1 more

Association between blood and semen BPA levels and ICSI outcomes in patients with male factor

Completed11 enrollment criteria

Choline Dehydrogenase and Sperm Function: Effects of Betaine

Men Carrying 2 Minor Alleles for Choline Dehydrogenase rs12676Male Infertility

The ability of sperm to swim is important for normal fertility. Men with a genetic variation in the gene coding for Choline Dehydrogenase (CHDH) have decreased energy production by sperm, and their sperm do not swim normally. The metabolic product of this gene is a nutrient called betaine (found normally in the diet as a part of many foods such as spinach, beets and grain products). This study tests whether treatment with betaine is safe and whether it can normalize energy production in sperm of these men and restore normal swimming ability.

Completed7 enrollment criteria

Tobacco and Sperm Genome: Effects of Smoking Cessation

Male Infertility

Tobacco is a male infertility risk factor. Many studies comparing smokers to non-smokers have shown effects on spermatogenesis and the quality of the male gamete. In vitro fertilization success rates are decreased in smokers and in natural procreation the time required to conceive (excellent fertility indicator) seems to be lengthened in the smoker. The prospective study that the investigators propose to carry out would make it possible to know the time required for the repair of the sperm abnormalities and in particular the DNA of the gametes generated by the smoking.

Completed13 enrollment criteria

Effect of New Oral Treatment for Hepatitis C Virus on Seminal Parameters

Male InfertilityHCV

Hepatitis C virus is commona viral infection. Direct-acting antiviral (DAA) oral drugs has been used in treatment of HCVs. the effect of these drugs on male infertility is still under investigation.

Completed2 enrollment criteria
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