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Active clinical trials for "Insulin Resistance"

Results 1361-1370 of 1557

The Study of HIV Protease Inhibitors and Their Effects on Glucose Metabolism

DiabetesHIV Infections1 more

The purpose of this study is to determine the mechanisms by which HIV protease inhibitors contribute to the development of diabetes in HIV-infected patients. The investigators propose that some HIV protease inhibitors impair insulin secretion and increase the production of glucose by the liver.

Completed3 enrollment criteria

Lipoprotein Metabolism in Hypertensive African-Americans

Cardiovascular DiseasesHeart Diseases3 more

To study relationships among lipoprotein metabolism, hypertension, and hyperinsulinemia-insulin resistance in African American males and females. The study was part of a Collaborative Project on Minority Health which investigated the mechanisms by which insulin contributes to cardiovascular disease.

Completed1 enrollment criteria

Insulin, Androgen, and Risk in African-American Women

Cardiovascular DiseasesDiabetes Mellitus4 more

To distinguish whether the observed gender differences in plasma insulin and insulin resistance reflect biologic differences, or whether the gender differences in insulinemia are determined by greater adiposity in women. Also, to determine if the hyperinsulinemia per se contributes to excess risk for cardiovascular disease in African American women. Finally, since higher androgenicity is linked with cardiovascular risk in women, to determine if the risk factors associated with hyperinsulinemia are modulated by sex hormones.

Completed1 enrollment criteria

Short to Long Effects of Whole Body Cryostimulation on Insulin Sensitivity Among Overweight

CryotherapyTraining2 more

Therapeutic effectiveness of coldness in relieving pain and reducing inflammation has been known for many years now. Over that time, various coldness therapies have gained in popularity, including winter swimming, snow baths or whole body cryostimulation (WBC) . Recent researches have shown positive effects of WBC on metabolic profile, low-to-moderate chronic inflammation and related diseases (e.g., obesity). WBC could be, thus, intended as an adjuvant method in the treatment of dysmetabolic conditions, such as overweight or obesity. WBC is a cheap easily accessible practice, with a few well-defined contraindications and limited non severe possible adverse events, if performed in specialized centres. At the same time, in sport science appears data, which indicated on inhibition of adaptive changes induced by regular training. The primary aim is to define, through a randomized controlled approach, the relative effectiveness of up to 20 consecutive sessions of either WBC, high-intensity intermittent training (HIIT), or their combination (WBC and HIIT) in improving the metabolic status of overweight and obese subjects. The effects will be assessed, at different time-points, in terms of insulin sensitivity and modification in the profile of hormones regulating the energy metabolism (adipokines, myokines, bone-derived hormones) and the inter-organ cross-talk.

Unknown status15 enrollment criteria

Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes...

PreDiabetes

This study evaluates the effects of oral supplementation with curcumin on the insulin sensitivity in subjects with prediabetes. The half of participants will receive curcumin and bioperine in combination, while the other half receive placebo.

Unknown status12 enrollment criteria

Effect of Proprietary Botanical Blend on Glycemic Control and Post-prandial Carbohydrate Absorption...

HyperglycemiaCarbohydrate2 more

This project will test a unique botanical formula designed to inhibit alpha amylase (the primary starch degrading digestive enzyme) and inhibit sucrase (the primary sucrose degrading digestive enzyme) in order to reduce acute post prandial glycemia regardless of nutritive carbohydrate source.

Unknown status12 enrollment criteria

12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal...

Metabolic SyndromeDyslipidemias2 more

The purpose of this study was to examine the impacts of a 12-week resistance band exercise program on insulin resistance, blood lipid profiles, body composition, and blood pressure in postmenopausal women with obesity. Thirty-six postmenopausal women participated in this study. Participants were randomly allocated into the resistance band training group (EX, n = 18) or the control group (CON, n = 18). The EX group performed a resistance band exercise training program 60 minutes per day, 3 times per week, for 12 weeks. The CON group did not participate in any exercise, dietary, or behavioral intervention. Blood glucose, insulin, homeostatic model of insulin resistance (HOMA-IR), blood lipids, blood pressure, and body composition were measured before and after 12 weeks of EX or CON.

Completed7 enrollment criteria

Copenhagen, Boston, Sydney

Insulin ResistanceInsulin Sensitivity1 more

The study investigates the regulation of muscle glucose utilization during exercise and enhanced insulin sensitivity in recovery from exercise. This will be investigated in lean control subjects and obese insulin resistant subjects.

Completed21 enrollment criteria

Effect of Empagliflozin + Linagliptin + Metformin + Lifestyle in Patients With Prediabetes

Prediabetic StateInsulin Resistance

Type 2 diabetes is a worldwide epidemic disease, and preventive strategies are needed to face this health problem. The goal of this trial is to evaluate the effect of empagliflozin + linagliptin + metformin + lifestyle on physiopathological parameters, sush as glucose metabolism, insulin resistance, pancreatic beta cell function and cardiovascular function in patients with impaired fasting glucose plus impaired glucose tolerance, during 12 months

Unknown status10 enrollment criteria

Fasting for Brain and Heart Health (FBHH)

Insulin Resistance

This pilot study is designed to investigate the effect of water-only fasting and refeeding on the homeostatic model of insulin resistance (HOMA-IR), a measure of insulin resistance.

Completed9 enrollment criteria
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