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Active clinical trials for "Intermittent Claudication"

Results 81-90 of 220

Efficacy and Safety of HMR1766 in Patients With Fontaine Stage II Peripheral Arterial Disease

Intermittent Claudication

The primary objective is to investigate in patients suffering from intermittent claudication due to Fontaine stage II Peripheral Arterial Disease (PAD) whether a 26-week treatment by HMR1766 on top of clopidogrel may result in an improvement of walking capacity, by comparing three doses of HMR1766 to placebo, and calibrating such effect versus cilostazol.

Completed12 enrollment criteria

Investigating Superion™ In Spinal Stenosis

Lumbar Spinal StenosisIntermittent Claudication

The proposed prospective, multi-center, randomized clinical trial is designed to evaluate the safety and effectiveness of the Superion™ ISS compared to the X-STOP® IPD® device in healthy adults suffering from at least 6 months of moderate spinal stenosis symptoms who have been unresponsive to conservative care.

Completed22 enrollment criteria

Angioplasty in Peripheral Arterial Disease and Endothelial Function

Peripheral Arterial Obstructive DiseaseIntermittent Claudication

To investigate whether endovascular revascualrization of infrainguinal arterial obstructive disease has an effect on brachial artery reactivity

Completed6 enrollment criteria

Exercise Rehabilitation of Younger and Older People With Claudication

Intermittent Claudication

The purpose of this study is to examine the effect of age and the effect of exercise intensity of rehabilitation programs on claudication pain symptoms and leg circulation of younger and older patients with intermittent claudication.

Completed10 enrollment criteria

Trial of VLTS-589 in Subjects With Intermittent Claudication

Intermittent ClaudicationPeripheral Vascular Disease

The purpose of this study is to evaluate the safety and tolerability of VLTS-589 compared with placebo, administered bilaterally to the lower extremities, in subjects with intermittent claudication and to determine the effect of VLTS-589 in peak walking time (PWT) for subjects receiving VLTS-589 compared with subjects receiving placebo.

Completed7 enrollment criteria

Safety and Efficacy of K-134 for the Treatment of Intermittent Claudication

Intermittent Claudication

The purpose of this study is to evaluate the safety and efficacy of K-134 for the treatment of intermittent claudication.

Completed7 enrollment criteria

A Phase 2 Study of the Effects of Sapropterin Dihydrochloride on Symptomatic Peripheral Arterial...

Intermittent Claudication

The purpose of this study is to evaluate whether sapropterin dihydrochloride is safe and effective in the treatment of intermittent claudication (IC) caused by peripheral arterial disease (PAD).

Completed35 enrollment criteria

Neuromuscular Electrical Stimulation (NMES) in Patients With Intermittent Claudication

Intermittent ClaudicationPeripheral Vascular Disease

This study will assess the benefit of a neuromuscular electrical stimulation device in patients suffering from symptoms and effects of lower limb intermittent claudication.

Completed16 enrollment criteria

Safety and Efficacy Study of Bosentan for Intermittent Claudication in Peripheral Arterial Disease...

Peripheral Arterial Disease

A prospective study, proof-of concept, randomized, controlled, parallel groups, simple blind was performed in 30 male patients (50-60 years old) with Intermittent Claudication (Rutherford category 1-2) recently diagnosed and clinical manifestations not exceeding 6 months with hypertension and/or dyslipidemia as unique co-morbility disorders. After a period of stabilization of the claudication distance in the Stress test (12.5%, 3.2 km/h) during 2 weeks, were randomized 1:1 to the experimental arm (Bosentan 62.5 mg twice daily/four weeks and 125 mg twice daily/eight weeks) or control group.

Completed11 enrollment criteria

Revascularization With Open Bypass Versus Angioplasty and STenting of the Lower Extremity Trial...

Superficial Femoral Artery StenosisSuperficial Femoral Artery Occlusion2 more

This is a prospective randomized controlled trial to compare clinical improvement, cost effectiveness and patency rates between new and improved Nitinol stents and open bypass surgery in the superficial femoral artery disease. Secondary outcomes also include comparing quality of life, re-intervention rate, mortality, morbidity and time to return to work or regular activities. Patients with superficial femoral artery lesions will be considered. Patients with TASC II A lesions will not be randomized but treated with PTA/stenting as standard of care. Patients with TASC II B and C lesions will be prospectively randomized into either receiving open bypass or stenting. Patients with TASC D lesions will be treated with open bypass surgery after angiography. The investigators will collect pre-procedure, peri-procedural and clinical follow-up data on all enrolled the patients.

Completed31 enrollment criteria
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