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Active clinical trials for "Carotid Stenosis"

Results 211-220 of 287

Emboshield® and Xact® Post Approval Carotid Stent Trial (The EXACT Study)

Carotid Artery DiseaseCarotid Stenosis2 more

To collect clinical outcome and device performance data on the FDA 510(k)-cleared Emboshield® BareWire™ Rapid Exchange Embolic Protection System and FDA-approved Xact® Rapid Exchange Carotid Stent System when used under commercial use conditions by a broad group of physicians entering the study with differing carotid artery stenting experiences.

Completed3 enrollment criteria

A Multi-Center Study to Evaluate Acute Safety and Clinical Performance of Paladin® Carotid Post-Dilation...

Carotid Artery Stenoses

The purpose of this study is to assess the safety and clinical performance of Paladin System in patients with carotid artery stenosis.

Completed19 enrollment criteria

TMAO and Atherosclerosis in HIV

Carotid Artery Plaque

In the present study, the investigators sought to prospectively examine the associations of plasma levels of TMAO (trimethylamine oxide), choline, betaine, dimethylglycine, and sarcosine with risk of incident carotid artery plaque, assessed by repeated B-mode carotid artery ultrasound imaging over a 7-year period, in women and men with and without HIV infection from the WIHS (Women Interagency HIV Study) and MACS (Multicenter Aids Cohort Study).

Completed2 enrollment criteria

The Role of Large Artery Plaque Imaging Features in Predicting Inflammation and Cognition

Cognitive ImpairmentCarotid Artery Plaque1 more

The invesigators propose a clinical study on patients undergoing carotid surgery (endarterectomy). The invesigators will determine carotid artery imaging features associated with (1) vessel wall inflammation, (2) downstream brain inflammation, and (3) cognitive benefit from surgery. This project will uncover links between inflamed carotid plaque and downstream brain inflammation. The invesigators will also determine carotid plaque imaging features predicting cognitive benefit from carotid surgery.

Unknown status8 enrollment criteria

Correlation Between Laboratory Markers and Origin of New Brain Ischemic Lesions After Carotid Stenting...

Carotid StenosisBrain Ischemia1 more

New brain ischemic lesions are detected in about 50% of patients undergoing carotid artery stenting (CAS). The aim was to assess correlation between selected laboratory markers and occurrence of new brain infarctions after CAS.

Completed5 enrollment criteria

Long-term Neurocognitive Sequelae of Subclinical Microembolization During Carotid Interventions...

Carotid Artery Stenosis

Microembolization is commonly associated with carotid artery stenting (CAS), but our understanding of subclinical microembolization is superficial. Through collaborative effects of multidisciplinary team-experts, novel approaches, and longitudinal evaluations, we hope to better understand the clinical significance and long-term cognitive effects of microemboli. This proposal may change our current clinical practice by providing a better outcome measure for carotid interventions and improving outcomes of CAS procedures through risk factor stratification. Our central hypothesis is that development of subclinical microemboli is associated with decline in cognitive function following CAS and that the risk of development of microemboli themselves is associated with patient- and procedure-related factors. We hope that this prospective study will help to clarify these important issues in the era of rapidly evolving percutaneous interventions.

Completed13 enrollment criteria

CorMatrix ECM for Carotid Repair Following Endarterectomy Registry

Carotid Stenosis

Assess device performance data from subjects undergoing patch angioplasty of the carotid artery following carotid endarterectomy using the CorMatrix ECM for Carotid Repair.

Completed5 enrollment criteria

A New Oxygen Mask for Carotid Endarterectomy Under Local Anaesthesia

StrokeTIA3 more

The purpose of this study is to determine the effectiveness of oxygenation and patient-acceptability of a novel oxygen face mask in patients undergoing carotid endarterectomies (CEAs).

Completed7 enrollment criteria

Cohort Study of Heart Rate Variability

Cardiovascular DiseasesMyocardial Ischemia4 more

To examine factors affecting heart rate variability (HRV) and the role of HRV in heart disease. Specifically, to examine the role of HRV: as a predictor of fatal and nonfatal ischemic heart disease over a six year follow-up of the Atherosclerosis Risk in Communities (ARIC) population based, bi-ethnic cohort; on the six year progression of carotid atherosclerosis measured by B-mode ultrasound; and on the incidence of hypertension. Also, to study the effect of elevated fasting insulin, glucose, diabetes mellitus, and other metabolic abnormalities on changes in HRV over nine years of follow-up.

Completed1 enrollment criteria

Paraoxonase and LDL Oxidation in Carotid Artery Disease

Carotid Stenosis

Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This study compares veterans who have significant carotid atherosclerosis on ultrasound examination with controls without carotid atherosclerosis. Both paraoxonase activity and genotype will be determined and compared between groups. The results may eventually make it possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to diminish the risk by early treatment.

Completed1 enrollment criteria
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