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Active clinical trials for "Cystitis, Interstitial"

Results 61-70 of 199

Physiotherapeutic Interventions Applied to the Bladder Pain Syndrome

Interstitial CystitisPainful Bladder Syndrome1 more

Related to urological and gynecological systems, patients with Bladdeer Pain Syndrome (BPS) often present pain, pressure and chronic discomfort in suprapubic and perineal area associated with low urinary tract symptoms. This condition can generates a negative impact in cognitive, social, behavioral and sexual quality of life. As Bladder Pain Syndrome originates from different causes and includes the genitourinary, gastrointestinal, musculoskeletal and neuropsychological systems, a multidisciplinary approach is needed with doctors,physiotherapists, psychologists and others. Physiotherapeutic interventions are recommended as a conservative treatment for patients with BPS. The physiotherapeutic interventions include the use of Biofeedback to relax the pelvic floor muscles and manual therapy (myofascial trigger points release) to decrease muscle tension. Transcutaneous electrostimulation (TENS) is used to decrease the pain and postural exercises to improve the pelvic mobility. In this study, our hypothesis was that women with BPS presented musculoskeletal dysfunction, and we tested a different physiotherapy approach that was not being used. The reason for that understanding was the presence of refractory urinary and pain symptoms notwithstanding the physiotherapy conventional treatment, such as manual therapy and biofeedback. To test our hypothesis, we decided to add either TENS or postural exercises to the conventional treatment. The objective of this study was to verify the effects of biofeedback (BF) and manual therapy (MT) associated with transcutaneous electrical nerve stimulation (TENS) or postural exercises (PE) in the treatment of bladder pain syndrome (BPS) in women regarding pain and urinary symptoms.

Completed0 enrollment criteria

Optimizing Psychosocial Treatment of Interstitial Cystitis/Bladder Pain Syndrome

Chronic Interstitial CystitisBladder Pain Syndrome12 more

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a severe pain condition affecting 3-8 million people in the United States lacking treatments that work. Emotional suffering is common in IC/BPS and known to make physical symptoms worse, and studies show patient sub-groups respond differently to treatment. By creating and testing a psychosocial intervention specific to IC/BPS, we will learn if this intervention improves patient wellness, who the intervention works best for, and how the body's pain processing influences outcomes.

Completed14 enrollment criteria

PK and Safety of SI-722 in IC/BPS

Interstitial CystitisBladder Pain Syndrome

This study is designed randomized, double-blind, placebo-controlled trial in Interstitial Cystitis/Bladder Pain Syndrome patients.

Completed8 enrollment criteria

Intravesical Botulinum Toxin A Injections in Treatment of Interstitial Cystitis Refractory to Conventional...

Interstitial Cystitis

This study was designed in a multicenter, randomized, double-blind, placebo controlled trial to test the actual therapeutic effects of intravesical BoNTA injection. The results of this study might provide clinical evidence for a better therapeutic regimen in the treatment of IC/PBS.

Completed44 enrollment criteria

Safety Study of Single Intravesical Doses of TTI-1612 in Women With Interstitial Cystitis/Bladder...

Interstitial Cystitis

The purpose of this study is to determine the safety and pharmacokinetics of TTI-1612 in women with interstitial cystitis/bladder pain syndrome.

Completed21 enrollment criteria

Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is...

Osteoarthritis PainChronic Low Back Pain1 more

Subcutaneous administration of tanezumab can result in changes in the number of nerves around the injection site in the thigh.

Completed7 enrollment criteria

An Effectiveness and Safety Study of PF-04383119 for the Treatment of Pain in Interstitial Cystitis...

CystitisInterstitial

The purpose of this study is to determine whether PF-04383119 is effective in the treatment of pain associated with interstitial cystitis.

Completed6 enrollment criteria

Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis...

Interstitial Cystitis

The purpose of this study is to assess the effects of dexmedetomidine while patients undergo treatment for Interstitial Cystitis (IC). The investigators goal is to demonstrate in patients with IC undergoing bladder hydrodistension that the use of dexmedetomidine as a supplemental anesthetic agent will result in better postoperative pain management.

Completed3 enrollment criteria

Interstitial Cystitis

Interstitial Cystitis

Patients with interstitial cystitis who meet eligibility requirements will be randomized to one of four treatment arms (3 RTX, Placebo). Study drug is administered as a single instillation within the urinary bladder. Study duration is 12 weeks.

Completed30 enrollment criteria

Efficacy of Amitriptyline for Painful Bladder Syndrome (PBS)

Bladder DiseasesInterstitial Cystitis

This is a randomized clinical trial study to test the efficacy and safety of amitriptyline in the treatment of patients newly diagnosed with painful bladder syndrome (PBS). PBS is defined by symptoms--frequent urination day and night and increasing pain as the bladder fills--according to the International Continence Society. The syndrome includes interstitial cystitis (IC), which has been estimated to affect as many as 700,000 people, mostly women. Estimates for PBS vary widely, but as many as 10 million people may suffer from this condition. Although amitriptyline is a Food and Drug Administration (FDA)-approved medication used for depression, the way it works makes it useful for treating the pain of fibromyalgia, multiple sclerosis, and other chronic pain syndromes. Prior small studies in interstitial cystitis (IC) suggested the drug may be a wise choice for this syndrome as well, because it blocks nerve signals that trigger pain and may also decrease muscle spasms in the bladder, helping to relieve the symptoms of pain and frequent urination.

Completed6 enrollment criteria
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