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Active clinical trials for "Lung Diseases, Interstitial"

Results 421-430 of 454

An International Patient-led Registry in Fibrotic Interstitial Lung Diseases Using eHealth Technology...

Pulmonary Fibrosis

The I-FILE study is a prospective multicenter, multinational observational study where the feasibility of a patient-led registry using home monitoring in patients with pulmonary fibrosis will be evaluated. The aim of the study is to gain more insights in disease behavior in patients with pulmonary fibrosis, so in future patients with progressive disease can be better identified.

Unknown status6 enrollment criteria

Study of Longidaze in the Prevention & Treatment of Pulmonary Fibrosis, Interstitial Lung Diseases...

FibrosesPulmonary

A study is being conducted to evaluate the efficacy and safety of Longidaze for the prevention and treatment of post-inflammatory pulmonary fibrosis and interstitial lung disease following COVID-19.

Unknown status17 enrollment criteria

The Effect of Spontaneous Respiration on Pulse-oximetry Measurements

Chronic Respiratory DiseaseCOPD1 more

This is a study designed to measure, characterize and describe changes on pulse-oxymetry values produced as a result of deep breaths in patients with stable chronic hypoxemic respiratory failure.

Unknown status9 enrollment criteria

Effects of Pulmonary Rehabilitation on Walking Speed in Patients With COPD or ILD Patients

Pulmonary DiseaseChronic Obstructive2 more

The aim of this study is to evaluate the effects of a three-week inpatient pulmonary rehabilitation (PR) program on the walking speed in patients with chronic obstructive (COPD) or interstitial lung disease (ILD).

Unknown status6 enrollment criteria

It's Not JUST Idiopathic Pulmonary Fibrosis Study

Interstitial Lung DiseaseIdiopathic Pulmonary Fibrosis

Study of progression of fibrosis in ILD

Unknown status15 enrollment criteria

Study of the Etiology and Immunological Pathogenesis in Acute Exacerbation of Idiopathic Pulmonary...

Interstitial Lung Diseases

Idiopathic pulmonary fibrosis (IPF) is a highly heterogeneous and lethal pathological process with limited therapeutic options, which is the most common and severe of the idiopathic interstitial pneumonias (IIPs). During the past 20 years, the incidence of IPF increased significantly. Most of IPF patients show a median survival time of 2-3 years after diagnosis. Five-year survival rate is 30%-50%. It's difficult to diagnose in the early stage of IPF. Once the patients go to hospital, it's already in the late stage. Now there is no effective therapy except lung transplant for IPF in clinical application. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is a fatal condition with high mortality (over 80%). Its etiology and pathogenesis remain unknown. There is a lack of effective treatment for it. Based on the investigators' long-term clinical observation, most cases of AE-IPF initially got "common cold" and had coryza, more cough, nasal obstruction,rhinorrhea, sore throat, some patients had fever, headache, and etc. Some of these patients' condition developed very rapidly and then became very severe similar to the situation of acute respiratory distress syndrome (ARDS). Why these AE-IPF patients were so hypersensitive to "cold"? What were the immunologic and pathological mechanisms of their lung lesions after patients exposed to "common cold"? How to effectively offer interventional treatment for AE-IPF? All the above questions are yet to be explained clearly. In the investigators' previous retrospective study, the investigators found that there were some obviously imbalanced immune responses in IPF patients, including increased cluster of differentiation 4 (CD4) T cell population, immunoglobulin and complements. The investigators also found highly expressed inflammatory cytokines (IL-17, MIG and IL-9) and high detection rates of pathogens in AE-IPF patients, especially serum immunoglobulin M (IgM) antibody of some respiratory virus. These findings provide a strong suggestion that there are some imbalance of immunologic function in IPF and there are relationship between AE-IPF and infection, especially "Cold" virus infection might be a key trigger for AE-IPF.

Unknown status9 enrollment criteria

Multicenter Study of Impulse Oscillometry in Chinese

Healthy SubjectsChronic Obstructive Pulmonary Disease3 more

The purpose of this study is to establish the reference values of impulse oscillometry (IOS) in healthy Chinese, and compare the indices of IOS in patients with lung disease, such as chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), and upper airway Obstruction (UAO).

Unknown status13 enrollment criteria

The Edinburgh Lung Fibrosis Molecular Endotyping (ELFMEN) Study

Idiopathic Pulmonary FibrosisInterstitial Lung Disease1 more

To prospectively study novel blood and lung biomarkers of disease activity in patients with IPF and other interstitial lung disease with the aims of prognostic modelling and disease clustering

Unknown status2 enrollment criteria

Definition of the Status of the Human Lung Stem Cell Niches ex Vivo in Tissue Biopsies Performed...

Lung DiseasesInterstitial

To characterize stem cell compartments in their niches in different clinical situations (non-diseased compared to emphysematous and fibrotic pulmonary tissue) and to assess their proliferative and developmental properties in vitro. To further implement lung organoid culture system in the drug screening and development of patient personalized medicine.

Unknown status3 enrollment criteria

An Expanded Access Program in Belgium to Provide Nintedanib to People With Lung Diseases Called...

Lung DiseasesInterstitial

This Expanded Access Program in Belgium is open to people with different lung diseases. This program provides a medicine called nintedanib to people who have no alternative treatment options. They can participate if they have a type of lung disease called non-IPF ILDs (chronic fibrosing interstitial lung diseases with a progressive phenotype other than idiopathic pulmonary fibrosis). Participants take 2 capsules of nintedanib a day. The treating physician checks the health of the participants and notes health problems that could have been caused by nintedanib. Participants receive nintedanib as long as they benefit or until nintedanib becomes commercially available in Belgium. For a patient to participate in this program, their treating physician should apply to Boehringer Ingelheim.

No longer available21 enrollment criteria
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