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Active clinical trials for "Intervertebral Disc Degeneration"

Results 21-30 of 415

2-level Cervical Disc Replacement Comparing Prodisc C SK & Vivo to Mobi-C

Symptomatic Cervical Disc Disease

A multi-center, prospective, randomized, controlled comparison of the prodisc C SK and prodisc C Vivo to the control, a similar, legally marketed total disc replacement device in subjects with symptomatic cervical disc disease (SCDD).

Recruiting16 enrollment criteria

OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study

Lumbar Spine DiseaseLumbar Spondylolisthesis3 more

The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar interbody fusion (LIF) by means of an intra-patient control model.

Recruiting25 enrollment criteria

Study of the ReGelTec HYDRAFIL System

Degenerative Disc Disease

A study designed to treat patients with back pain associated with degenerative lumbar disc disease.

Recruiting28 enrollment criteria

Single-Armed Use of ViviGen Cellular Bone Matrix in Patients Undergoing Posterolateral Lumbar Surgery...

Degenerative Disc DiseaseSpinal Stenosis2 more

This is a prospective, single-arm post market study of patients to assess fusion in one or multiple continuous levels of the lumbosacral spine (L1-S1) using ViviGen Cellular Bone Matrix. All subjects will be followed out to 24 months for final assessment.

Recruiting21 enrollment criteria

A Single Dose of BRTX 100 for Patients With Chronic Lumbar Disc Disease (cLDD)

Lumbar Disc Disease

This is a double-blind, saline-controlled, and randomized study with blinded assessments using a single dose. Subjects that have a current diagnosis of chronic lumbar disc disease and meet eligibility criteria will be enrolled. Chronic lumbar disc disease is defined as back and/or radicular pain with degeneration of the disc confirmed by patient history, physical examination, and radiographic measures such as computed tomography (CT), magnetic resonance imaging (MRI), plain film, myelography, discography, or other acceptable means.

Recruiting60 enrollment criteria

An Open Label, Randomized-controlled Trial to Assess Efficacy Safety of HYALODISC With Physical...

Degenerative Disc Disease(DDD)

The objective of this study is to determine if one single X-ray-guided intradiscal injection of 8 mg/mL of HYALODISC combined with PEP will be more effective than only physical exercise program in patients with LBP from degenerative disc disease. Enrolled patients will be randomly assigned to one of the two treatment groups below: Group 1: One single X-ray-guided intradiscal injection (25 gauge) of 8 mg/mL of HYALODISC combined with PEP. The investigator will use one syringe for each involved disc, up to a maximum of three discs. Group 2: PEP alone. The injection will be administered at V1 baseline (day 0). Any physical activity (e.g. jogging, tennis, weightlifting, prolonged upright position) in the 48 hours following the injection should be avoided. Both groups (Group 1 and Group 2) will be treated with PEP according to a standardized protocol. Starting one week after the baseline visit (V1), patients will be prescribed of 18 physiotherapy sessions that will take place under supervision of physiotherapist twice a week in the first seven weeks (weeks 2-8) and once a week in the next four weeks (weeks 9-12). Twelve repetitions of each exercise for 3 sets will be performed during PEP session. Moreover, in addition to the 18 sessions performed with supervision of the physiotherapist, all patients will be instructed how to do exercises at home and will be asked to continue these exercises once a week in the first seven weeks (weeks 2-8) and twice a week in the next four weeks (weeks 9-12).

Recruiting31 enrollment criteria

Clinical Decision-Making and Virtual Reality Exercise

Degenerative Lumbar Spinal StenosisDegenerative Disc Disease2 more

Degenerative lumbar spine disease (DLSD) is common in elderly individuals and can result in pain, muscle weakness, and paresthesia. Numerous studies have reported that patients with DLSD usually have postural balance instability, which may affect the patient's gait, functional activities, and quality of life. The investigators propose to achieve the following aims: (1) to develop a clinical balance diagnostic tool to identify patients with DLSD who may require lumbar surgery (2) to investigate the effects of virtual reality skateboard exercise training on gait and balance in patients with DLSD.

Recruiting7 enrollment criteria

Post Marketing Clinical Follow up Study for MagnetOs Putty in Patients With Degenerative Disc Disease...

Degenerative Disc Disease

This study is a post-marketing clinical follow-up study for MagnetOs Putty. MagnetOs Putty is a synthetic bone-like material which is routinely used by surgeons as a treatment for patients with degenerative disc disease who will undergo surgery for spinal fusion (extreme lateral interbody fusion (XLIF)). MagnetOs Putty will be used according to the instructions for use.

Recruiting22 enrollment criteria

Comparison of Rigid and Non-Rigid Interbody Fusion Device for Cervical Degenerative Disc Disease...

Cervical Disc Degeneration

Rigid interbody fusion device in bulk configuration has been widely used in anterior cervical discectomy and fusion (ACDF) surgery. It is a randomized, prospective, multicenter clinical study to compare rigid and non-rigid fusion device in ACDF for cervical degenerative disc disease.

Recruiting24 enrollment criteria

Minimally Invasive Decompression and Fusion Versus Open for Degenerative Lumbar Stenosis

Lumbar Spinal StenosisIntervertebral Disc Degeneration

The purpose of this study is to determine the effectiveness of minimally invasive decompression and fusion over the traditional open decompression and fusion in patients with single-level lumbar stenosis caused by degenerative spondylolisthesis. Postoperative follow-up will continue for 12 months. Сlinical, safety, radiological and cost-effectiveness endpoints will be evaluated.

Recruiting17 enrollment criteria
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