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Active clinical trials for "Brain Neoplasms"

Results 951-960 of 1541

AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors...

Childhood Atypical Teratoid/Rhabdoid TumorChildhood Central Nervous System Germ Cell Tumor19 more

This phase I trial is studying the side effects and best dose of AZD2171 in treating young patients with recurrent, progressive, or refractory primary CNS tumors. AZD2171 may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Completed45 enrollment criteria

Tandutinib in Treating Patients With Recurrent or Progressive Glioblastoma

Adult Brain TumorAdult Giant Cell Glioblastoma3 more

This phase I/II trial is studying the side effects and best dose of tandutinib and to see how well it works in treating patients with recurrent or progressive glioblastoma.Tandutinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

Completed53 enrollment criteria

A Trial Using Velcade Plus Chemoradiation for Central Nervous System, Head and Neck, and Cervical...

Brain CancerHead and Neck Cancer2 more

The purpose of this study is to determine the safety of Velcade when used with chemoradiation in cancer patients.

Completed7 enrollment criteria

Study of Systemic and Spinal Chemotherapy Followed by Radiation for Infants With Brain Tumors

Brain Tumors

The purposes of this study are to find the highest dose of mafosfamide that can be given without causing severe side effects, to see how well the combination of these chemotherapy drugs and lower doses of radiation work to delay or stop the growth of the tumor, and to evaluate the pharmacokinetics (how the body handles) of Mafosfamide.

Completed10 enrollment criteria

Antineoplaston Therapy in Treating Children With Brain Tumors

Childhood Brain Tumors

RATIONALE: Current therapies for childhood brain tumors provide limited benefit to the patient. The anti-cancer properties of Antineoplaston therapy suggest that it may prove beneficial in the treatment of childhood brain tumors. PURPOSE: This study is being performed to determine the effects (good and bad) that Antineoplaston therapy has on children (> 6 months of age) with brain tumors.

Completed48 enrollment criteria

Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain...

Brain TumorsCentral Nervous System Tumors2 more

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctors to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: Phase I trial to study the effectiveness of combination chemotherapy plus peripheral stem cell transplantation in treating infants with malignant brain or spinal cord tumors.

Completed48 enrollment criteria

Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary Brain Tumors

Brain and Central Nervous System Tumors

RATIONALE: Monoclonal antibodies can locate tumor cells and deliver radioactive tumor-killing substances such as radioactive iodine to them without harming normal cells. PURPOSE: This randomized phase I/II trial is studying the side effects, best way to give, and best dose of radiolabeled monoclonal antibody and to see how well it works in treating patients with primary brain tumors.

Completed42 enrollment criteria

Stereotactic Radiosurgery in Treating Patients With Brain Tumors

Adult Central Nervous System Germ Cell TumorAdult Malignant Meningioma12 more

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. PURPOSE: Phase I trial to study the effectiveness of stereotactic radiosurgery in treating patients who have brain tumors.

Completed2 enrollment criteria

Temozolomide and Vinorelbine in Treating Patients With Recurrent Brain Metastases

Metastatic Cancer

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase I/II trial to study the effectiveness of temozolomide and vinorelbine in treating patients who have recurrent brain metastases.

Completed20 enrollment criteria

Radiation Therapy With or Without RSR13 in Treating Patients With Brain Metastases

Metastatic Cancer

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs such as RSR13 may make tumor cells more sensitive to radiation therapy. PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy to the brain with or without RSR13 in treating patients who have brain metastases.

Completed48 enrollment criteria
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