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Active clinical trials for "Macular Edema"

Results 41-50 of 850

A Study to Investigate RO7200220 in Diabetic Macular Edema

Diabetic Macular Edema

Study BP43445 is a phase II, multicenter, randomized, double-masked, active comparator-controlled study to investigate the efficacy, safety, tolerability, pharmacokinetics, and pharmacodynamics of RO7200220 administered intravitreally in participants with diabetic macular edema. Only one eye will be chosen as the study eye. The duration of the study will be up to 76 weeks.

Recruiting19 enrollment criteria

Safety and Effect of Intravitreal Injection of a Derivative of Nucleoside Reverse Transcriptase...

Diabetic Macular Edema

This study is designed to assess the safety and initial evidence of efficacy of the novel compound SOM-401 (K8), a derivative of a nucleoside reverse transcriptase inhibitor, in subjects with untreated, clinically significant, diabetic macular edema (DME).

Recruiting23 enrollment criteria

RO7200220 in Participants With Uveitic Macular Edema

Uveitic Macular Edema

This study will assess the efficacy and safety of RO7200220 in participants with uveitic macular edema.

Recruiting15 enrollment criteria

AG-73305 Single Ascending Dose Cohort Study in DME

Diabetic Macular Edema

This is a multi-centered, open-labeled, single ascending-dose-cohort study to evaluate 4 dosing cohorts of AG-73305 administered by intravitreal injection in patients with diabetic macular edema (DME).

Recruiting11 enrollment criteria

Cytokine and Visual Outcome Variations in Eyes Receiving Aflibercept

Age Related Macular DegenerationDiabetic Macular Edema2 more

Objective: To determine the association between baseline aqueous cytokine levels and treatment intervals for patients under a variable dosing regimen with intravitreal aflibercept in patients with neovascular age-related macular degeneration (nAMD), macular edema secondary to retinal vein occlusion (RVO) and diabetic macular edema (DME). Methods: A prospective, single-centre study will be performed containing 3 sub-studies according to each study population: nAMD, macular edema secondary to RVO and DME. Inclusion criteria are: patients followed at St. Michael's Hospital with the diagnosis of nAMD, macular edema secondary to RVO or DME. Patients will be excluded if visual acuity is worse than counting fingers, with macular pathologies causing any structural changes to the retina, have received anti-VEGF injections or photocoagulation therapy 6 months prior to study, intraocular surgery 3 months prior to study, any history of vitreoretinal surgery or ocular inflammation in the study eye, use of systemic or topical anti-inflammatory or steroids, patients on dialysis for renal failure, allergy to the study drug or fluorescein, <18 years old, women who are pregnant. All patients will be treated with aflibercept intravitreal injections on a variable dosing regimen: Patients with DME will be examined monthly and receive mandatory injection for the first three months (baseline, weeks 4 and 8). Afterwards, they will continue to be seen monthly and the need for new injections will be decided upon the clinical findings at each visit. An anterior chamber (AC) tap will be done if an injection is required at the visit. Patients with nAMD and RVO will be examined monthly and receive mandatory injection for the first three months. From weeks 12 until 72 (month 18), the visits will be scheduled at increasing 2-weeks intervals based on the stability of the ocular condition and response to treatment. At each visit, an injection and AC tap will be performed. The maximum interval in between injections is 12 weeks. If the disease becomes unstable, the interval in between injections is shortened and, once it stabilizes, the treatment frequency is extended again. In all patients, baseline aqueous humour specimens will be obtained prior to the first aflibercept intravitreal injection and follow-up samples will be taken immediately prior to subsequent injections based on the treatment regimens for cytokine analysis in the end of the follow-up.

Recruiting18 enrollment criteria

DSAEK/DMEK and Cystoid Macular Edema - the Role for Topical NSAIDs (Nepafenac) (DMEC)

Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)Descemet Membrane Endothelial Keratoplasty (DMEK)

The DMEC trial is a randomized clinical two-arm trial comparing inflammation and cystoid macular edema for the medication regimens postoperative topical NSAIDs and steroids to only postoperative topical steroids in patients undergoing corneal endothelial transplantations (DSAEK or DMEK).

Recruiting11 enrollment criteria

The PRIME Study: A Randomized, Controlled, Prospective Study

Patient PreferencePatient Outcomes3 more

To investigate the outcomes of patients undergoing bilateral RLE surgery with treatment of dexamethasone intracanilicular insert compared to topical standard care steroid. Desiged to look at patient preference comparing the insert to drops and will also look at patient outcomes including inflammatin and risk of cystoid macular edema post-operatively.

Recruiting14 enrollment criteria

Effect of Corona Virus on Intravitreal Injections

Diabetic Macular EdemaAge-Related Macular Degeneration3 more

During pandemic of corona virus, patients compliance may be affected. We aim to study the factors lead to unregulated visits and its implications on the final visual outcome.

Recruiting2 enrollment criteria

Results of Suprachoroidal Steroids Injections in Two Chorioretinal Diseases

Central Serous ChorioretinopathyIrvine-Gass Syndrome2 more

Suprachoroidal injection is a safe way for intraocular drug delivery. It was used to treat various retinal conditions.

Recruiting3 enrollment criteria

Effectiveness of Periocular Drug Injection in CATaract Surgery

Macular EdemaCystoid Macular Edema4 more

Cystoid macular edema (CME) is a major cause of suboptimal postoperative visual acuity after cataract surgery. Topical steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs) are used to prevent CME. However, noncompliance with eye drops may compromise the effectiveness of treatment. Dropless periocular drug delivery during cataract surgery may improve the outcomes and cost-effectiveness of cataract surgery, and may alleviate the burden on homecare organizations.

Recruiting16 enrollment criteria
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