Sequential Treatment of Extra-Corporeal Shock Wave Combined With aUtologous Bone marRow Mesenchymal...
Ischemic Heart DiseaseThis study is designed to evaluate the efficacy, safety and tolerability of autologous bone marrow derived mesenchymal stem cells compared to placebo (sham operation) when administered via percutaneous coronary infusion to patients with ischemic heart disease, who are screened by D-SPECT and have pretreated with 3-month cardiac shock wave therapy.
EndoACAB vs PCI for LAD Revascularization
Coronary Artery DiseaseCardiovascular Diseases1 moreThe purpose of this study is to determine which treatment option is better for patients who have isolated coronary artery disease (blockages of one vessel supplying blood to the heart muscle). The treatment options compared in this study are: Endoscopic coronary arterial bypass Percutaneous Coronary Intervention. This study is aimed to determine the best treatment for patients with coronary artery disease.
Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following...
Coronary Heart DiseaseCardiovascular DiseasesThe objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart surgery is practical for the anaesthetist treating the patients and whether it is feasible for the research team to recruit patients and follow them up after the operation.
Evaluation of the Strategy of "One-stop" Endovascular Treatment for Concomitant Coronary Artery...
Coronary Artery DiseaseAortic Atherosclerotic DiseaseThe study is a prospective, randomized, controlled, exploratory trail to evaluate the strategy of "one-stop" endovascular treatment for concomitant coronary artery disease and aortic atherosclerotic disease.
Cardiac Metabolic Modulator Treatment for Improvement of Diastolic Function in Patients With Coronary...
Coronary Heart DiseaseDiastolic DysfunctionBased on accumulating evidence showing that impaired cardiac energetic metabolism plays important role in the mechanism of cardiac diastolic dysfunction,the study is designed to evaluate whether metabolic modulator treatment with trimetazidine could have beneficial effects on patients with coronary heart disease(CHD) and ventricular diastolic dysfunction.This study is a prospective,randomised,open-label trial to assess the efficacy of trimetazidine treatment in improving diastolic function in CHD patients with diastolic dysfunction.
Fastigial Nucleus Stimulation for Coronary Heart Disease
Coronary DiseaseTo observe the effects of fastigial nucleus stimulation on serum inflammation, oxidative stress related factors, cardiac autonomic function and prognosis in patients with coronary heart disease
Intravascular Balloon Lithotripsy in Left Main Stem Percutaneous Coronary Intervention
Coronary Artery CalcificationLeft Main Coronary Artery DiseaseThe IVL Left Main study is a prospective non-randomised pilot study to investigate the mechanical and procedural outcomes and safety of distal left main stenting with coronary lithotripsy in addition to standard techniques in patients with calcific left main disease and a clinical indication for revascularisation.
Treatment of Patients With Atherosclerotic Disease With Methotrexate-associated to LDL Like Nanoparticles...
AtherosclerosisCoronary Artery Disease1 moreThe investigators propose a prospective, randomized, double-blind, placebo-controlled study. The purpose of the study is to evaluate the safety and efficacy of an anti-inflammatory agent methotrexate in a cholesterol-rich non-protein nanoparticle (MTX-LDE) in patients with stable coronary disease. Patients with multi-vessels stable coronary disease will be randomized to receive MTX-LDE IV or placebo-LDE IV each 7 days for 12 weeks. The primary and main secondary endpoints will be analyzed by coronary and aortic CT angiography, that will be performed before the first treatment cycle, four weeks after the last drug infusion and 12 months after randomization. Patients will undergo clinical and laboratory safety evaluations before each treatment cycle, four weeks after the last cycle and 12 months after randomization. An algorithm for drug suspension based on clinical and laboratory finding will be followed.
Efficacy and Safety of New Generation Drug Eluting Stents Associated With an Ultra Short Duration...
Stable AnginaSilent Myocardial Ischemia1 moreThe main objective of the SENIOR study is to establish the efficacy and safety of the everolimus eluting stent with a biodegradable abluminal polymer (SYNERGY II) associated with a short dual antiplatelet therapy (DAPT) in patients ≥75 years old, suffering from stable angina, silent ischemia (1 month DAPT) or acute coronary syndromes (6 months DAPT) related to significant coronary artery disease and requiring percutaneous coronary intervention. The primary end point is to demonstrate that SYNERGY II in patients ≥75 years old is associated with a lower rate of the composite rate of major cardiovascular and cerebrovascular events (all-cause death, myocardial infarction, stroke, ischemia-driven target lesion revascularization) and a similar risk of stent thrombosis than bare metal stent at one year.
The Study of Active Transfer of Plaque Technique for Unprotected Distal Left Main Bifurcation Lesions...
Coronary Heart DiseaseA Prospective Multi-center Randomized Trial Assessing the Efficacy and Safety of Active Transfer of Plaque vs. Provisional T Stenting for the Treatment of Unprotected Distal Left Main Bifurcation Lesions