PHOTOTHERAPY VERSUS PREGABALIN IN TREATMENT OF REFRACTORY UREAMIC PRURITIS
Refractory Uremic PruritisPatients will be randomly assigned into 2 groups: Group A: (20 patients) will receive NB UVB phototherapy 3 sessions per week for 2 months. Group B: (20 patients) will receive pregabalin oral therapy (50mg after each dialysis session) for 2 months.
Klotho in Chronic Kidney Disease-associated Pruritis (CKD-aP)
Chronic Kidney Disease-associated PruritusStudying whether Klotho and FGF23 have a role in UP and whether their expression change by BB-UVB with the improvement of pruritus.
Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical...
Hemodialysis-Associated PruritusMalnutrition-Inflammation-Cachexia Syndrome3 moreIn this study, the investigators aimed to observe the effects of medium cut-off dialysis filters and high-flux dialysis filters on malnutrition inflammation score, uremic itching, restless leg syndrome, anemia, and ESA treatment, which are prominent complications in hemodialysis, and routine follow-up parameters.
PK Comparisons of Bepotastine Besilate 10 mg and Bepotastine Salicylate 9.64 mg
Allergic RhinitisUrticaria1 moreTo compare the relative bioavailability and pharmacokinetic characteristics of a newly developed bepotastine formulation, bepotastine salicylate, with a conventional formulation, bepotastine besilate, in healthy subjects with a single dose, randomized, open-label, 2-sequence -2period crossover study.
Adding Nalbuphine for Control of Intrathecal Morphine Pruritus
PruritusPain5 moreIntrathecal morphine causes intense itching which is very bothersome. Nalbuphine antagonizes this effect when given intravenously. This trial is to find out if nalbuphine added to intrathecal morphine has an effect on morphine related pruritus while still maintaining adequate analgesia.
Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin...
PruritusTo evaluate the inter-arm and inter-period reproducibility of the dermal blood flow response induced by a skin prick of histamine, subjects will receive histamine (10 mg/ml) and negative control skin pricks on the volar surface of both forearms during two subsequent study visits to allow an intra-individual comparison. Changes in dermal blood flow will be measured during the hour after the skin pricks with laser Doppler and/or laser speckle contrast imaging.
Non Interventional Clinical Investigation of Ectoin Ear Spray in Skin Treatment of Outer Ear Canal...
PruritusDermatitis1 moreIn this observational study, insights regarding the tolerability and influence on the quality of life of the topical treatment with Ectoin Ear Spray compared to Normison ear spray shall be gained under real life conditions in patients with chronic eczematous irritations and pruritus of the outer ear canal.
A Study to Assess the Mass Balance Recovery, Metabolite Profile and Metabolite Identification of...
PruritusThe primary objectives of the study are: To assess the mass balance recovery after a single PO dose of [14C]-SK-1405 To provide plasma, urine and faecal samples for metabolite profiling and structural identification
Survey on Itch in Outpatients of a University Clinic
ItchThis study is to investigate the pruriception (i.e. the perception of the character and intensity of itch), the impact of itch on quality of life, the response to itch and the subjective efficacy and preferences of the different treatment options among patients with different skin diseases. Better insights into these aspects might help to optimize itch treatment in clinical Settings.
Influence of Antipruritics on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin....
PruritusIn order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the administration of certain antipruritics. Besides, the influence of these antipruritics on the dermal blood flow response induced by the topical application of cinnamaldehyde and capsaicin will be evaluated. Changes in dermal blood flow will be measured with laser speckle contrast imaging.