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Active clinical trials for "Pruritus"

Results 51-60 of 264

Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With...

PruritusUremic Pruritus

The primary purpose of this study is to: Evaluate the safety and pharmacokinetic profile of repeated doses IV CR845 over one week in patients who are undergoing hemodialysis. (Part A) This study is also investigating whether repeated doses of IV CR845 over two weeks is safe and effective in reducing the intensity of itching in hemodialysis patients with uremic pruritus (Part B).

Completed26 enrollment criteria

Study of the Efficacy, Safety and Tolerability of Serlopitant for the Treatment of Pruritus (Itch)...

PruritusPrurigo Nodularis

Study of the efficacy, safety, and tolerability of serlopitant for the treatment of pruritus in adults with prurigo nodularis

Completed27 enrollment criteria

A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Severe...

Chronic Kidney DiseasesPruritus

This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of 3 dose levels of oral CR845 compared to placebo in reducing the intensity of itch in chronic kidney disease (CKD) patients with moderate-to-severe pruritus. This study will consist of a Screening Period, a 7-day Run-in Period, a 12 week Treatment Period, and a Follow-up Visit (approximately 7 days after the last dose of study drug).

Completed13 enrollment criteria

PRISM Study-Pruritus Relief Through Itch Scratch Modulation

Prurigo Nodularis

To investigate the anti-pruritic efficacy and safety of Nalbuphine Extended Release (ER) (NAL ER) tablets in Prurigo Nodularis. Subjects will be randomized to NAL ER (or matching placebo) with the primary endpoint evaluation at Week 14. During the open label extension, subjects who received NAL ER will continue on NAL ER and subjects who received placebo will crossover to NAL ER.

Completed18 enrollment criteria

Efficacy of Abrocitinib for Reducing Pruritus in Adults With Prurigo Nodularis and Chronic Pruritus...

Prurigo NodularisPruritus3 more

The primary objective is to assess the efficacy, safety, and tolerability of Abrocitinib for the treatment of Prurigo Nodularis (PN) or Chronic Pruritus of Unknown Origin (CPUO) in patients experiencing moderate to severe pruritus.

Completed21 enrollment criteria

Proof of Concept of VLY-686 in Subjects With Treatment-Resistant Pruritus Associated With Atopic...

Treatment-resistant Pruritus Associated With Atopic Dermatitis

The purpose of this study is to test whether VLY-686 can reduce chronic pruritus in subjects with treatment-resistant pruritus associated with atopic dermatitis in comparison with placebo.

Completed32 enrollment criteria

Blinded, Randomized Study Evaluating Aurstat Versus Control in the Treatment of Atopic Dermatitis...

PruritusAtopic Dermatitis

To demonstrate the ability of Aurstat to reduce pruritus in subjects with mild to moderate atopic dermatitis. Efficacy results will be based on subject assessment, IGA, and photographic evidence based on ordinal scales for tolerability.

Completed18 enrollment criteria

Open Label Extension Study of Nalbuphine HCl ER in Hemodialysis Patients With Uremic Pruritus

Uremic PruritusPruritus

The primary objective of the study is to evaluate the overall safety of nalbuphine HCL ER tablets during a treatment period of up to 24 weeks.

Completed6 enrollment criteria

A Study of Oral Ergocalciferol to Treat Pruritis in Hemodialysis Patients

Pruritis

Pruritis (itching) is common in many people with chronic renal failure on hemodialysis. There may be many different reasons for the pruritis. Efforts to treat the problem have not been very effective. Vitamin D levels have been found to be low in many hemodialysis patients. Since vitamin D plays an important role in the skin and is effective in treatment of certain skin conditions that involve pruritis, it may have a role in treatment of pruritis in hemodialysis patients. The objective of the investigators study is to determine the effect of supplementation with oral vitamin D2 (ergocalciferol) on pruritis in hemodialysis patients.

Completed10 enrollment criteria

Acupressure in Pruritus for Atopic Dermatitis

Atopic Dermatitis

The purpose of this study is to see if acupressure will be effective at reducing itch in people with atopic dermatitis (AD).

Completed6 enrollment criteria
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