Effects of Xiidra on Closed Eye Tear Film Leukocytes in Dry Eye Disease
Ocular DiscomfortOcular Inflammation3 moreEvery night during sleep, there is an accumulation of white blood cells in the closed eye. The closed eye white blood cells are predominantly neutrophils, but there is a small population (3%) of T cells. The effects of these closed eye white blood cells on dry eye disease pathogenesis have yet to be fully elucidated, but preliminary evidence suggests that closed eye neutrophils may have an associated hyperactivity and increased degranulation in dry eye disease that could contribute to epithelial instability. As an anti-T cell therapy, Xiidra offers an opportunity to better understand how the closed eye white blood cells are recruited and activated. This study also seeks to verify the proposed mechanism of action.
A Study to Evaluate the Performance and Safety of Artelac Rebalance® Versus Vismed in the Management...
Dry EyeThe objective of this investigation is to show that the performance of Artelac Rebalance eye drops is non-inferior to that of Vismed eye drops in subjects with moderate to severe dry eye, and to assess the safety of Artelac Rebalance after a 90-day (± 10 day) treatment administered 3 to 5 times per day.
Comparison of Mucin Levels at the Ocular Surface of Visual Display Users With and Without Dry Eye...
Dry Eye DiseaseThe study aimed to evaluate 1) if levels of the glycocalyx membrane mucins, including MUC1, MUC4, MUC16 and MUC20, are altered in conjunctival cells of visual display users With and Without Dry Eye Disease, and 2) if mucin levels correlate with dry eye clinical diagnostic data.
Differential Diagnosis of Sjögren's Versus Non-Sjögren's Dry Eye
Keratoconjunctivitis SiccaDry Eye Syndromes2 moreTo investigate and compare the burden of dry eye in Sjögren's syndrome dry eye vs non-Sjögren's syndrome dry eye, as well as investigate the diagnostic potential of tear film mucins and various inflammatory cytokines evaluated by tear fluid analysis and impression cytology.
A Retrospective Analysis of Restasis® Benefits in Dry Eye Contact Lens Patients
Dry Eye SyndromeA retrospective analysis of Restasis® benefits in dry eye contact lens patients.
Correlation Study of Corneal Nerve Changes and Dry Eye in Contact Lens Wearers
Contact Lens ComplicationDry EyeThis study aims to analyze the changes of corneal nerve morphology and function in contact lens-related dry eye(CLADE) patients and further discuss the role of corneal nerve in the genesis and development of CLADE.
Safety and Efficacy of NovaTears® + Omega-3 (0.2%) Eye Drops on Signs and Symptoms of Dry Eye
Evaporative Dry Eye DiseaseThis PMCF study is carried out following successful CE marking of NovaTears® + Omega-3 and is intended to generate systematic clinical data on the safety and performance of the device when used in accordance with the intended purpose.
Effects of Cataract Extraction Surgery and Limbal Relaxing Incision on Corneal Sensation and Dry...
Dry EyeThis is a multicenter evaluation of the effects of the cataract extraction and limbal relaxing incisions (LRI) on corneal sensation and dry eye signs and symptoms.
RPS InflammaDry Detector™ to Determine MMP-9 Levels in Tears
Dry EyeThe RPS InflammaDry Detector™ is intended to detect elevated MMP-9 in human tears to aid in the diagnosis of patients with signs or symptoms of dry eye disease, in conjunction with other methods of clinical evaluation.
TearLab Refractive Surgery Dry Eye Study
Dry Eye SyndromesThe primary objective of this study is to determine how pre & post-operative tear osmolarity levels relate to rates of dry eye symptoms related to refractive surgery and if differences exist in patients who are pre-treated with ocular lubricants vs. those treated only post-operatively.