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Active clinical trials for "Kidney Diseases"

Results 1-10 of 3857

Safety, Tolerability, and Feasibility of Empagliflozin Therapy in Dialysis-dependent ESKD

End-stage Kidney DiseaseKidney Disease7 more

The purpose of this study is to find out if empagliflozin, a new diabetic medication that has been shown to be very effective in lowering the risk of heart failure, is safe and tolerated in dialysis patients. In the recent years, empagliflozin has become a major tool to prevent heart failure hospitalization and to reduce the risk for cardiovascular death in diabetic and non-diabetic patients. Although patients with severe chronic kidney disease and ESKD have very high risk of heart failure and cardiovascular death, they have been excluded from all of the previous studies. If this medication is found to be well tolerated and safe in dialysis patients through this study, future clinical studies can evaluate if this medication can also reduce the risk of heart failure and cardiovascular death in dialysis patients.

Recruiting11 enrollment criteria

Evaluating the Use of the Qidni/D Hemodialysis System by Subjects With End-Stage Renal Disease

Kidney DiseaseEnd-Stage

The main goal of this clinical study is to evaluate the safety of the Qidni/D Hemodialysis System in patients with end-stage renal disease. The main question it aims to answer is: Is the Qidni/D safe for performing hemodialysis? Participants will be subjected to one treatment of hemodialysis for up to 4 hours with the use of the Qidni/D.

Recruiting25 enrollment criteria

Feasibility of Aggressive Albuminuria Reduction in Biopsy-Proven Diabetic Nephropathy - A Pilot...

Diabetic Kidney Disease

The purpose of this trial is to investigate the feasibility and safety of implementing a protocol-based treatment aggressively targeting albuminuria in subjects with biopsy-proven diabetic nephropathy and severely elevated albuminuria. If this approach is feasible, the results of the trial will inform the design of a large-scale randomized clinical trial to evaluate the effect of this treatment on hard kidney endpoints (initiation of dialysis, kidney transplantation, and death from kidney failure) in subjects with biopsy-proven diabetic nephropathy and severely elevated albuminuria.

Recruiting25 enrollment criteria

Effects of Finerenone on Vascular Stiffness and Cardiorenal Biomarkers in T2D and CKD (FIVE-STAR)...

Type 2 DiabetesChronic Kidney Diseases

To evaluate the effects of finerenone on vascular stiffness and cardiorenal biomarkers in patients with type 2 diabetes and chronic kidney disease.

Recruiting21 enrollment criteria

A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity...

Overweight or ObesityCKD1 more

The main purpose of this study is to investigate the effect of retatrutide on renal function in participants with overweight or obesity and chronic kidney disease (CKD), with or without Type 2 Diabetes (T2D). The study will lasts around 31 weeks.

Recruiting11 enrollment criteria

Late Feasibility Study to Evaluate Safety and Efficacy of AWAK PD Device in Subjects With ESKD....

Chronic Kidney Diseases

The goal of this late feasibility clinical trial is to evaluate the safety and effectiveness of the Automated Wearable Artificial Kidney (AWAK) peritoneal dialysis (PD) device in subjects with end-stage kidney disease. The main questions it aims to answer are: the success of AWAK PD therapies when used in a home-setting the safety and effectiveness of the AWAK PD system Participants will: be titrated to find a suitable AWAK PD prescription be trained on how to use the AWAK PD system independently use the AWAK PD system at home for at least 7 days

Recruiting12 enrollment criteria

A Study of BION-1301 in Adults With IgA Nephropathy

IgA NephropathyImmunoglobulin A Nephropathy

Safety and Efficacy of BION-1301 in Adults with IgA Nephropathy

Recruiting27 enrollment criteria

Phase 2 Study of INV-202 in Patients With Diabetic Kidney Disease

Diabetic Kidney Disease

The study is designed to assess the efficacy, safety, tolerability, and transformation within the human body of INV-202 investigational drug in the treatment of adult participants with a diagnosis of Diabetic Kidney Disease due to either Type 1 diabetes mellitus or Type 2 diabetes mellitus

Recruiting34 enrollment criteria

Renal Mechanism of SGLT2 Inhibition

Type 2 DiabetesDiabetic Kidney Disease

Canagliflozin is an oral drug which is currently approved for use in patients with type 2 diabetes by the US Food and Drug Administration (FDA). Canagliflozin acts by increasing salt and sugar loss in the urine, and has shown to protect heart, kidney, and blood vessel function in patients with type 2 diabetes. However, it is unknown how canagliflozin protects the kidneys from disease. Therefore, this study plans to learn more about how canagliflozin works to protect against diabetic kidney disease in adults with type 2 diabetes. This study will use state-of-the-art kidney imaging, kidney biopsies and detailed testing of kidney function to determine the mechanisms of protection afforded by canagliflozin.

Recruiting25 enrollment criteria

A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease...

Chronic Kidney DiseasesPruritus

This is a multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of oral difelikefalin administered as a 1 mg tablet once daily compared to placebo in reducing the intensity of itch in advanced chronic kidney disease (CKD) patients with moderate-to-severe pruritus. This study is comprised of an Efficacy Assessment Phase and a Long-term Extension Phase. The Efficacy Assessment Phase includes a double-blind 12-week Treatment Period (Treatment Period 1), and the Long-term Extension Phase includes a double-blind Treatment Period (Treatment Period 2) of up to 52 weeks.

Recruiting11 enrollment criteria
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