Cohort Study Comparing Short Daily Hemodialysis (HD) With Conventional HD
End-stage Renal DiseaseThrombocytopathy1 moreThis study is examining the effects of short daily hemodialysis on platelet function, fluid volume control, arterial stiffness and patient quality of life, as compared to conventional hemodialysis.
Project Aura: Co-design of a Home-based Monitoring Service
Anemia of Chronic Kidney DiseaseCo-design of a home-based haemoglobin monitoring system with participants with anaemia of chronic kidney disease.
Safety and Efficacy of Sofosbuvir Based Antiviral Regimen for Treating Hepatitis C in Patients With...
CKD With Hepatitis CAll patients with chronic kidney disease (stages 3, 4 and 5) and chronic dialysis patients with HCV infection attending nephrology and Hepatology OPD or getting outpatient dialysis at the dialysis unit of ILBS.
Mechanisms of Infertility and Hormonal Changes in Patients With Chronic Kidney Disease
InfertilityPatients with chronic kidney disease (both men and women), especially those with terminal renal failure, manifest infertility. There has been demonstrated several hormonal changes in patients on dialysis. Increased levels of luteinizing hormone (LH) has been seen in men (12). In women the opposite has been reported. The number of spermatocytes is reduced and a disturbance in maturation has been observed. This project is aimed to study the influence of uremic milieu on fertility in men and women. The hypopituitary/hypothalamus gland axis and hormonal levels will be studied.
Inflammation in Peritoneal Dialysis Patients: Effect of Obesity
End-Stage Renal DiseaseRenal Disease4 moreOur study addresses the following research question: What is the role of obesity in modulating inflammation and innate immune function, as well as the overall responsiveness of innate immune cells (such as macrophages, neutrophils, and other peripheral leukocytes) in patients undergoing peritoneal dialysis? The investigators hypothesize that obesity will lead to increased inflammation in patients undergoing peritoneal dialysis.
Safety and Efficacy of Plant-based Diets in Hemodialysis Patients
Renal DiseaseThe purpose of this proof-of-concept controlled-feeding study is to evaluate the impact of plant-rich diets, with and without high-potassium fruits and vegetables, on phosphorus and potassium homeostasis in hemodialysis (HD) patients.
Role of Chronic Kidney Disease in Cardiovascular Disease
Cardiovascular DiseasesHeart Diseases2 moreThe purpose of this study is to determine how the progressive loss of kidney function influences cardiovascular disease.
Detecting Markers of Kidney Function With Intravenous Microdialysis
Kidney DiseasesPatients will be invited to participate from an outpatient nephrology clinic at Hammersmith Hospital. They will have a microdialysis catheter inserted into a peripheral vein and connected to a sampling system. The samples will be sent for analysis in the hospital laboratory. All medical devices to be used are already CE-marked and approved for these purposes.
Evaluation of New Markers to Assess Kidney Function
Chronic Kidney DiseaseGlomerular filtration rate (GFR) is widely accepted as the best index of kidney function in health and disease, and accurate values are required for optimal clinical decision making and in large-scale epidemiologic studies and clinical trials. Current recommended methods for measuring GFR are expensive, cumbersome to administer and assay and requires urine collection and administration of radioactive materials. The purpose of this study is to evaluate two non-radioactive markers (iohexol and gadolinium) compared to urinary clearance of inulin and iothalamate. The investigators hypothesize that plasma clearance of non-radioactive markers will be unbiased compared to a gold standard and more precise than currently used urinary clearance methods.
BK Virus Post-Kidney Transplant: New Practice Versus Traditional Approach
BK Virus InfectionBK Virus NephropathyThe investigator's aim in this study is to evaluate the impact of a new standard of care protocol for the treatment of BK viremia and nephropathy (BKVAN), which includes switching from Tacrolimus to equivalent dose of Cyclosporine in patients who have been diagnosed with BK viremia or BKVAN based on their viral load, overall graft function (estimated glomerular filtration rate), acute rejection, and rate of graft loss due to rejection or BKVAN.