Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical...
CardiomyopathyRenal ImpairmentTo determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects with preclinical Diastolic dysfunction (PDD) and renal (kidney) dysfunction
Study to Assess the Safety and PK of GSK573719 and GSK573719/GW642444(VI) Combination in Healthy...
Pulmonary DiseaseChronic ObstructiveThis study will assess the safety and pharmacokinetics of inhaled GSK573719 and GSK573719/vilanterol combination in healthy subjects and in subjects with severe renal impairment. The results of the study will provide guidance on the use of this product in subjects with severe renal impairment.
Pharmacokinetics of Dabigatran Etexilate (Pradaxa®) During Haemodialysis
Cardiovascular DiseasesKidney Failure1 moreThe current study will allow the assessment of pharmacokinetics, pharmacodynamics, elimination rate and clearance of dabigatran etexilate during and following haemodialysis in ESRD patients.
A Study of Fostamatinib in Subjects With Impaired Kidney Function
Rheumatoid ArthritisRenal ImpairmentA 2 stage study to evaluate the amount of fostamatinib in the blood and urine in subjects with impaired kidney (renal) function compared with healthy volunteers with normal renal function. Stage 1 will include healthy subjects and subjects with end stage renal disease, while Stage, 2 may include subjects with mild, moderate and/or severe renal impairment dependent on the outcome of Stage 1. The study will also evaluate safety and tolerability in subjects with renal impairment.
A Clinical Trial to Compare and Evaluate the Pharmacokinetic Characteristics and the Safety of Fimasartan...
Renal ImpairmentThe purpose of this study is to compare and evaluate the pharmacokinetic characteristics and the safety of fimasartan in renal impairment patients and healthy volunteers.
Post-marketing Safety Study in Patients With Moderate Renal Insufficiency Who Receive Omniscan for...
Chronic Kidney DiseaseRenal InsufficiencyThis will be an international, multi-center, post-marketing surveillance study in patients with moderate renal insufficiency who are administered gadodiamide, Omniscan, during a MRI. Omniscan will be administered intravenously at the medical discretion of the prescribing physician.
Pharmacokinetics (PK) and Metabolism of FTY720 in Patients With Severe Renal Impairment and Healthy...
Renal InsufficiencyThe purpose of this study is to compare the pharmacokinetics of FTY720 and its metabolites in patients with severe renal insufficiency and in matched, healthy volunteers. This study will allow a better understanding of the effects of renal insufficiency on the disposition of FTY720.
Pharmacokinetics and Safety Study of Azacitidine in Cancer Patients With and Without Impaired Renal...
MDSAML4 moreThe purpose of this study is to evaluate three things. The first being whether azacitidine is absorbed in the body at the same rate or proportion for different concentrations. The second is to determine the effect renal impairment has or does not have on the absorption of azacitidine. The third is to determine if azacitidine is safe and well tolerated in patients with renal function impairment.
Comparison Between Effects of Two Iron Preparations on Protein in the Urine
Kidney FailureChronic2 moreThis study will compare the effects of sodium ferric gluconate complex and iron sucrose on urine concentrations of various chemicals including protein
Trial of Aerobic Exercise in Patients Undergoing Outpatient Hemodialysis
Kidney FailureChronicRandomized controlled trial comparing effects of ergometer exercise during hemodialysis to effects of pedometer use outside of hemodialysis on exercise capacity, functional status, quality of life and adequacy of hemodialysis.