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Active clinical trials for "Kidney Neoplasms"

Results 71-80 of 809

Impact of Telemonitoring for the Management of Side Effects in Patients With Melanoma, Lung or Renal...

MelanomaLung Cancer1 more

The ipilimumab and nivolumab combination is now part of the standard of care for the treatment of melanoma, renal and lung cancer patients. Grade 3/4 adverse events (AEs) occur in 30 to 60% of patients included in clinical trials. Grade 3/4 AEs are more frequently observed (50-60% of patients) in melanoma because ipilimumab is administrated at 3mg/kg in this population. Among these AEs, early detection of immune related AEs is critical to an adequate medical management. In this context, dedicated tools for remote monitoring of these patients are crucial. The investigators developed within the Immucare consortium a simplified medical questionnaire which is addressed weekly to the patients. This questionnaire along with an algorithm gives to the clinician regular feedback on their patients' general symptoms. The investigators herein want to evaluate in a randomized prospective trial the efficacy of this remote monitoring to reduce the time between the start of AE and the reporting to the medical team, which could lead to detect and treat earlier AEs induced by nivolumab and ipilimumab in the melanoma, lung and renal cancer patients' population.

Recruiting8 enrollment criteria

Exploratory Interventional Study of Prognostic Serum Biomarkers of Cancer Progression

MelanomaNon Small Cell Lung Cancer1 more

Exploratory interventional study of prognostic serum biomarkers of cancer progression. Study of the relationship between the blood levels of soluble PDL1 and β2-microglobulin, and the clinical course of a metastatic solid tumor treated with a first-line therapeutic of checkpoint immune inhibitor.

Recruiting10 enrollment criteria

Impact of Chronic Renal Failure on Plasma Exposure of Kinase Inhibitors in Patients Treated for...

Kidney Neoplasm

The study of the blood concentration of ITK what are pazopanib and cabozantinib at 1 month and 3 months from the start of treatment will allow to evaluate the impact of renal failure on their efficacy and toxicity in patients with metastatic kidney cancer.

Recruiting13 enrollment criteria

GI Organ Tracking Via Balloon Applicators

Esophageal CancerKidney Cancer11 more

The hypothesis of this study is that an occlusion balloon catheter placed in the stomach via an oral or nasogastric route will be safe and permit tracking of the stomach during radiation therapy.

Recruiting7 enrollment criteria

Light Therapy and Occupational Therapy Fatigue Management-Based Intervention for Patients With Genitourinary...

Bladder CarcinomaGenitourinary System Neoplasm2 more

This clinical trial evaluates light therapy and occupational therapy in improving cancer related fatigue (CRF) patients with genitourinary cancers. Light therapy is a non-pharmacological and evidence-based intervention for managing fatigue in cancer patients. The use of light therapy can provide a low burden, inexpensive, and easy to disseminate intervention approach that can potentially have a larger impact on CRF. In addition, occupational therapy is a standard, but often underutilized, component of the multi-disciplinary approach to cancer care. Using the combination of light therapy and occupational therapy may be effective in CRF management.

Recruiting17 enrollment criteria

Study of Durvalumab and Guadecitabine in Advanced Kidney Cancer

Advanced Kidney CancerKidney Cancer1 more

This is a single arm, multi-centre (via Big Ten Cancer Research Consortium) phase Ib/II study of patients treated with durvalumab 1500 mg IV q 4 weeks in combination with guadecitabine at the recommended phase 2 dose subcutaneously for 5 consecutive days. Eligible patients will have metastatic RCC with a clear cell component, ECOG performance status of 0-1, have received 0-1 prior therapy but no prior anti-PD-1/PD-L1/CTLA4 (Cohort 1, 36 subjects). Study treatment could potentially continue for up to 13 cycles (52 weeks).

Active62 enrollment criteria

Denosumab and Pembrolizumab in Clear Cell Renal Carcinoma

Renal Cell CarcinomaClear Cell1 more

This Single-arm, multicentre, phase 2 trial aims determine the activity and safety of pembrolizumab and denosumab in advanced clear cell renal cell carcinoma (ccRCC).

Active34 enrollment criteria

A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab...

MelanomaNon-Small Cell Lung Cancer6 more

This is a Phase 1a/1b, open-label, multicenter, global, dose-escalation study designed to evaluate the safety, tolerability, immune response, and pharmacokinetics of autogene cevumeran (RO7198457) as a single agent and in combination with atezolizumab (MPDL3280A, an engineered anti-programmed death-ligand 1 [anti-PD-L1] antibody).

Active62 enrollment criteria

Durvalumab and Tremelimumab in Treating Patients With Muscle-Invasive, High-Risk Urothelial Cancer...

HydronephrosisInfiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant20 more

This pilot phase I trial studies the side effects of durvalumab and tremelimumab in treating patients with muscle-invasive, high-risk urothelial cancer that cannot be treated with cisplatin-based therapy before surgery. Immunotherapy with monoclonal antibodies, such as durvalumab and tremelimumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread.

Active32 enrollment criteria

A Study to Evaluate the Safety and Efficacy of Nivolumab With Ipilimumab in Participants With Untreated...

Kidney Neoplasms

The purpose of this study is to assess the safety and efficacy of nivolumab combined with ipilimumab in intermediate and poor-risk participants with previously untreated advanced renal cell carcinoma (RCC) or metastatic RCC (mRCC) in India.

Active9 enrollment criteria
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