search

Active clinical trials for "Laryngostenosis"

Results 1-7 of 7

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

Tracheal StenosisLaryngeal Stenosis

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

Enrolling by invitation11 enrollment criteria

Clinical Study of Curcumin in Preventing Postoperative Adhesion of Bilateral Vocal Cords

Glottic Web of LarynxLaryngeal Stenosis4 more

To provide a novel therapy idea and method to solve the clinical problem of postoperative adhesion of bilateral vocal cords, patients enrolled in this study will be applied with curcumin on both wound sites of bilateral vocal cords after the surgery on the bilateral vocal cord endoscopically.

Recruiting8 enrollment criteria

Effects of Interleukin (IL)-17A Inhibition on Idiopathic Subglottic Stenosis

Idiopathic Subglottic Stenosis

The purpose of this phase 2 study is to examine if inhibiting IL-17A activation using the biologic drug Taltz, in idiopathic subglottic stenosis patients will decrease scar fibroblast proliferation therefore reducing or eliminating the need for invasive or repeat surgeries.

Not yet recruiting8 enrollment criteria

Study of Mitomycin-C Application in Laryngotracheal Stenosis

Laryngeal StenosisSubglottic Stenosis1 more

This is a randomized, prospective, double-blind, placebo-controlled clinical trial of the use of mitomycin-C topical application as an adjunctive treatment in the endoscopic surgical treatment of patients with laryngotracheal stenosis. We hypothesize that the use of mitomycin-C improves patient outcome in the endoscopic surgical treatment of laryngotracheal stenosis.

Terminated8 enrollment criteria

Treatment of Laryngotracheal Stenosis Using Mesenchymal Stem Cells

Tracheal StenosisLaryngeal Stenosis1 more

The trial evaluates the safety and efficacy of the olfactory mucosa-derived mesenchymal stem cells based therapy for the patients with chronic laryngeal and tracheal stenosis

Completed12 enrollment criteria

Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants

Disorder of Upper Respiratory SystemLaryngostenosis1 more

This study aims to test a new groundbreaking treatment for narrowing of the voicebox and upper windpipe, which can be due to injury, inflammatory disease or cancer treatment. Narrowing of the voicebox or upper windpipe can leave patients dependant on a tracheostomy tube to breath through (a tube or hole in the neck), which can require a high level of care with regular hospital visits and can lead to recurrent chest infections. Regular surgical procedures may be necessary to widen the airway. Speaking may be very difficult or not even possible, breathing is usually a struggle and swallowing can also be affected. Patients feel very tired all the time. The new treatment tested by this study is an implant that will partially replace the voicebox or upper windpipe in order to cure the narrowing. The implant is based on a human donor voicebox or windpipe that has been processed with detergents and enzymes in order to remove all the cells from the donor, leaving a 'scaffold' of connective tissue. The patient's own stem cells are removed from the bone marrow, then are grown on the scaffold in the laboratory. These cells will form the cartilage in the wall of the scaffold. A split skin graft from the patient may be needed to line the inside of the implant. The implant can be considered 'living' due to the cells grown on it, and this type of treatment is referred to as 'tissue engineering' or 'regenerative medicine'. Once these cells have attached and started to grow on the scaffold, it is ready to be implanted into the patient, and an operation is performed which occurs in two separate stages. The final stage of the operation involves removing the narrow section of voicebox or upper windpipe and implanting the scaffold to reconstruct it. Patients will be followed up for two years after this operation, with investigations such as CT scans, examination of the voicebox and windpipe with a flexible camera (bronchoscopy) and blood tests performed at specific times. It is intended that this treatment will significantly improve patients' symptoms resulting in better breathing, swallowing and voice function, reducing the need for repeated hospital visits and procedures and enhancing patients' quality of life.

Withdrawn15 enrollment criteria

The Effectiveness of Reconstructive Microsurgery on the Clinical and Functional State of Laryngeal...

Larynx DiseaseLaryngeal Stenosis

To improve diagnostic methods for patients with laryngeal stenosis for the optimal determination of the technique of surgical treatment.

Unknown status7 enrollment criteria
1

Need Help? Contact our team!


We'll reach out to this number within 24 hrs