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Active clinical trials for "Optic Atrophy, Hereditary, Leber"

Results 21-30 of 30

Pupil Dynamics and Color Vision for the Detection of Eye Diseases

Retinitis PigmentosaLeber's Hereditary Optic Neuropathy1 more

The development of new oculometry techniques allows fine and dynamic measurements of pupillary diameter and use in routine clinical practice. The preliminary results obtained with innovative devices on healthy sjuets make it possible to envisage a clinical study on a population of patients suffering from retinal pathologies. This is a "proof of concept" study, which, if the expected results are confirmed, will make it possible to consider a study on a larger population, as well as the industrial development of a commercial device.

Completed16 enrollment criteria

Post Authorisation Safety Study With Raxone in LHON Patients

Leber's Hereditary Optic Neuropathy (LHON)

This study is a multicentre, prospective, non-interventional post-authorisation safety study (PASS) of the clinical outcomes for patients with LHON treated with Raxone®. No medication will be provided as part of this study. Raxone® will be obtained through commercial channels.

Completed4 enrollment criteria

Study With Idebenone in Patients With Chronic Vision Loss Due to Leber's Hereditary Optic Neuropathy...

Leber's Hereditary Optic Neuropathy

The objective of the study is to determine whether administration of idebenone can shorten the time to improvement of visual acuity in patients with chronic vision loss due to LHON.

Withdrawn6 enrollment criteria

REALITY LHON Registry

Leber Hereditary Optic Neuropathy

This study is a multi-country retrospective and cross-sectional observational study of affected LHON subjects, based on retrospective subjects' medical chart abstractions and cross-sectional administration of patient-reported outcomes (PROs).

Completed6 enrollment criteria

Historical Case Record Survey of Visual Acuity Data From Patients With Leber's Hereditary Optic...

Leber's Hereditary Optic Neuropathy (LHON)

The purpose of this survey is to collect visual acuity data from patients with LHON in order to establish the clinical course (natural history) and visual acuity outcomes in patients with a genetically confirmed diagnosis of LHON. In addition, this survey will generate data that will serve as comparator for the open-label study SNT-IV-006.

Completed6 enrollment criteria

RHODOS Follow-up Single-visit Study

Leber's Hereditary Optic Neuropathy

This study aims to evaluate the current visual acuity of SNT-II-003 participants and compare this with the last visit from the SNT-II-003 study.

Completed1 enrollment criteria

Expanded Access Program for Idebenone in Patients With Leber's Hereditary Optic Neuropathy Who Completed...

Leber's Hereditary Optic Neuropathy

Expanded Access Program for Idebenone in Patients with Leber's Hereditary Optic Neuropathy who completed the LEROS Study

No longer available4 enrollment criteria

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

Leber Hereditary Optic Neuropathy (LHON)

The objective of this survey is to establish the clinical course of vision loss and recovery in patients with a genetically confirmed diagnosis of Leber Hereditary Optic Neuropathy (LHON). Visual acuity changes over time from onset of symptoms and from visual acuity nadir will be the main endpoint analysed. The survey will collect historically documented visual acuity data for all patients at participating sites with a genetically confirmed diagnosis of LHON. No exclusion criteria apply. Patients are not required to attend the clinic for the survey. Data will be collected in a completely anonymous manner. Ethical approvals and data release agreements will be obtained as required by local regulations.

Completed1 enrollment criteria

EAP_GS010_single Patient

Leber Hereditary Optic Neuropathy (OpticAtrophy2 more

Expanded Access Use for a single patient of Bilateral Intravitreal Injection of GS010 in a Single Subject Affected with G11778A ND4 Leber Hereditary Optic Neuropathy

Available18 enrollment criteria

Emergency Administration of EPI-743 to a Single Patient With Leber's Hereditary Optic Neuropathy...

Leber's Hereditary Optic Neuropathy

Expanded access Protocol to treat LHON subjects with EPI743

No longer available9 enrollment criteria

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