Study of Renal Denervation in Patients With Heart Failure
Heart FailureCongestive heart failure is a common disorder in which the heart cannot pump enough blood to meet the needs of the rest of the body. Poor sodium handling by the kidneys is a damaging effect of heart failure, and it leads to symptoms of congestion such as shortness of breath or ankle swelling. Recent studies suggest that reducing the nerve activity to a kidney could reduce sodium retention and blood pressure. An improvement in the way the kidneys handle sodium may reduce disease progression and decrease symptoms for heart failure patients.
Left Ventricular Assist Device Combined With Allogeneic Mesenchymal Stem Cells Implantation in Patients...
Heart FailureIschemic CardiomyopathyThe aim of the study is to investigate safety and efficacy of intramyocardial implantation of allogeneic mesenchymal stem cells in patients with end-stage ischemic cardiomyopathy undergoing left ventricular assist device implantation.
The Study to Evaluate Efficacy and Safety of Candesartan vs Losartan in Hypertension With Heart...
HypertensionThe purpose of this study is to compare efficacy and safety of candesartan and losartan in hypertension with heart failure.
Biomarkers to Classify Heart Failure
Heart FailureThe purpose of this study is to evaluate existing biomarkers and see if they can be used to accurately diagnose the etiology of heart failure.
Dietary Approaches to Stop Hypertension in 'Diastolic' Heart Failure 2 (DASH-DHF 2)
Diastolic Heart FailureHypertensive Heart DiseaseThe purpose of this study is to examine how dietary changes affect the heart and blood vessels in patients with hypertension (high blod pressure) who have a condition called 'heart failure with preserved ejection fraction" (HFPEF). This condition is also known as "diastolic heart failure" or "heart failure with normal ejection fraction", and occurs even though the heart's pumping function is normal.
Safety and Efficacy of Doxycycline in Patients With Non-Ischemic Cardiomyopathy
Non-ischemic CardiomyopathySystolic Heart Failure (NYHA II-III)Non-ischemic cardiomyopathy and heart failure are highly influenced by the presence of systemic inflammation. Doxycycline is a FDA-approved drug to treat bacterial infections which also shows powerful anti-inflammatory effects. In this study we plan to determine the effects of Doxycycline in patients with stable heart failure and non-ischemic cardiomyopathy on peak of aerobic exercise capacity (peak V02) and ventilator efficiency measured with a cardiopulmonary test.
PD-HF: A Trial of Peritoneal Dialysis in Patients With Severe Heart Failure and Chronic Kidney Disease...
Heart FailureChronic Kidney DiseaseThis trial is to establish whether ultrafiltration by peritoneal dialysis is a clinically effective treatment for patients with severe heart failure and moderate chronic kidney disease, thus improving quality of life and symptoms.
Re-evaluation of Optimal Re-synchronisation Therapy in Patients With Chronic Heart Failure
Chronic Heart FailureThe objective of the study is to demonstrate that in patients with chronic heart failure who receive optimal medical treatment for this condition and have indication for Cardiac Resynchronisation Therapy, the implantation of a pacemaker (index group) is not inferior to defibrillator (control group) with respect to all-cause mortality.
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe...
CardiomyopathyHypertrophic3 moreThe purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
A Dose Finding Study to Assess the Effect of LIK066 Compared to Placebo or Empagliflozin in Patients...
Diabetes Mellitus and Heart FailureThis was a dose-finding study to evaluate the efficacy, safety and tolerability of 3 different doses of LIK066 compared to placebo or empagliflozin in T2DM patients with heart failure