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Active clinical trials for "Leiomyoma"

Results 1-10 of 415

Carboprost (Hemabate) for Fibroid Resection

Fibroid UterusGynecologic Disease2 more

The purpose of this research study is to determine if low-dose (i.e., a fraction of what is commonly used) carboprost (Hemabate) helps facilitate fibroid removal (myomectomy).

Recruiting6 enrollment criteria

A Phase II/III Study of Efficacy and Safety of SHR7280 Tablets in Subjects With Menorrhagia With...

Uterine Fibroids With Menorrhagia

Phase II:To explore the optimal effective dose of SHR7280 tablets in subjects with menorrhagia with uterine fibroids as a phase III treatment dose. Phase III:To evaluate the efficacy of the selected dose of SHR7280 compared with placebo in reducing menstrual bleeding in subjects with menorrhagic uterine fibroids in phase II studies.

Recruiting33 enrollment criteria

Effects of Simvastatin on Uterine Leiomyoma Size

Fibroid UterusFibroid Tumor4 more

The study aims to study the effect of simvastatin on the size of uterine fibroids.

Recruiting36 enrollment criteria

Utility of Liposomal Bupivacaine Transversus Abdominal Plane Block for Open Myomectomy

Fibroid Uterus

The study team will be randomizing patients presenting for open myomectomy to either received transversus abdominal plane blocks with either liposomal bupivacaine or standard bupivacaine. The study team will be analyzing the impact of local anesthetic on opiate consumption as the investigator's primary endpoint with other secondary endpoints.

Recruiting5 enrollment criteria

Efficacy and Safety of BG2109 in Subjects With Heavy Menstrual Bleeding Associated With Uterine...

Uterine FibroidsHeavy Menstrual Bleeding

The primary objective of this study is to demonstrate the superior efficacy versus placebo of BG2109 alone and in combination with add-back therapy for the reduction of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.

Recruiting13 enrollment criteria

A Phase 3B Study to Evaluate Bone Mineral Density With Long-Term Use of Relugolix Combination Tablet...

Uterine FibroidsEndometriosis

The purpose of this clinical trial to characterize changes in bone mineral density during continuous treatment with relugolix combination tablet for up to 48 months (4 years) and 1 year of post-treatment follow-up in premenopausal women with heavy menstrual bleeding associated with uterine leiomyomas (fibroids) or with moderate-to-severe pain associated with endometriosis.

Recruiting25 enrollment criteria

Effects of Vitamin D, Epigallocatechin Gallate, Vitamin B6, and D-Chiro-inositol Combination on...

LeiomyomaUterine

Randomized (1:1) double-blind, single-center controlled trial to evaluate the efficacy of 3 months of treatment with Epigallocatechin gallate, vitamin D, D-Chiro-inositol, and vitamin B6 on symptoms related to uterine fibroids

Recruiting10 enrollment criteria

FRIEND: Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural...

LeiomyomaUterine

The objective of this study is to determine the effect of low caffeine green tea extract containing 45% epigallocatechin gallate (EGCG) on fibroids and subsequent pregnancy and live births in women seeking fertility treatment. The population will consist of 200 women desirous of conceiving, ages ≥18 to ≤40 years (at time of consent), and known to have class 2-6 fibroids, according to the FIGO staging system.

Recruiting35 enrollment criteria

Treatment of Benign Uterine Disorders Using High Intensity Focused Ultrasound (MR-HIFU)

Uterine FibroidsAdenomyosis

MRI-guided high intensity focused ultrasound (MRI-HIFU) has been proven to be a safe and effective method in treating uterine fibroids and also adenomyosis. However, systematic studies on the effect of this treatment on factors affecting fertility are still lacking. Also quite little is known about body's systemic response to MRI-HIFU. Thus the aim of this study is to obtain more information on the systemic response of the body to the HIFU-treatment when treating non-malignant disease as well as to study the effect of MRI-HIFU on factors affecting fertility. Women with symptomatic uterine fibroids or adenomyosis suitable for MRI-HIFU treatment are recruited to this study. The severity of symptoms will be assessed with UFS-QoL and the same questionnaire will also be used in follow-up 3, 6 and 12 months after treatment. Blood, urine and endometrium samples will be collected pre- and postoperatively and during follow-up 3, 6 and 12 months after the treatment. From these samples detailed analysis of the immunological, inflammatory and hormonal response will be performed. As this is the first study in Finland of treating uterine fibroids and adenomyosis using MRI-HIFU, also a report about the efficacy of the MRI-HIFU in treating the uterine disorders will be published, and a key tool in assessing the treatment outcome would be the UFS-QoL questionnaire. Also new methods for improving patient selection as well as treatment efficacy will be evaluated in this study.

Recruiting17 enrollment criteria

Study of the Safety and Contraceptive Efficacy of Relugolix Combination Therapy in Women With Uterine...

Contraception

The purpose of this study is to assess the contraceptive efficacy of relugolix combination therapy.

Recruiting26 enrollment criteria
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