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Active clinical trials for "Leukemia, Myelogenous, Chronic, BCR-ABL Positive"

Results 881-890 of 939

Study With Intravenous Busulfan And Fludarabine Myeloablative Conditioning Regimen For HLA Identical...

Acute Myeloid LeukemiaMyelodysplastic Syndrome2 more

Analyze the results of conditioning with once-daily dose intravenous busulfan and fludarabine in patients undergoing HLA identical sibling Allogeneic HSCT for myeloid malignancies.

Completed11 enrollment criteria

Pulmonary Vasculopathy Under Second-line Therapy of Chronic Myeloid Leukemia

Chronic Myeloid Leukemia

Chronic myelogenous leukemia (CML) is a chronic myeloproliferative disorder characterized by a translocation between chromosome 9 and 22, leading to a pathogenic tyrosine kinase signal transduction protein. CML can be treated with tyrosine kinase inhibitors (TKIs), which inhibit BCR/ABL kinase, such as imatinib. In about 20% of CML patients who are treated by imatinib, a complete cytogenetic response cannot be achieved. The other two novel TKIs (dasatinib and nilotinib), achieve higher rates of complete cytogenetic response and they are proposed as second-line therapy for imatinib-resistant patients or for those who do not tolerate imatinib. Dasatinib inhibits BCR/ABL kinase in about >300 times in vitro in more than imatinib and also inhibits several other kinases, including the Src family. Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries. Imatinib and nilotinib do not inhibit the Src. Incident cases of precapillary PH have been reported in patients who have CML treated with the dasatinib. Improvements were usually observed after withdrawal of dasatinib. This study is designed to identify incident cases of dasatinib-associated PH and describe pulmonary vascular changes induced by dasatinib. As comparison population will be patients who receive another second-line TKI (nilotinib).

Completed14 enrollment criteria

Mid-to Long-Term Outcomes in Chronic Myeloid Leukemia (CML) Patients With Complete Cytogenetic Response...

Chronic Myeloid Leukemia

Rationale: At present, virtually no evidence exists regarding mid to long-term patient-reported health outcomes (e.g., health related quality of life-HRQOL) of CML patients treated with Imatinib. Purpose: the results of this research will provide preliminary evidence-based data on an number of issues from the patients' perspective, including adherence to therapy issues.

Completed11 enrollment criteria

Analysis of Genetic Factors Related to Predisposition and Prognosis of Hematological Malignancies...

Acute Myeloid LeukemiaChronic Lymphocytic Leukemia1 more

There are naturally occuring variations in the genetic makeup of all of us. Some of these variations may contribute to a change in susceptibility toward different diseases or change the prognosis. We are studying these genetic variations in patients with leukemia. The genes we are studying are those which influence detoxification of drugs and toxins.

Completed2 enrollment criteria

Preparatory Work to Assess Adherence to Oral Chemotherapy

Chronic Myeloid Leukemia

This study to find out more about how patients take their anticancer medications and challenges related to taking cancer medications.

Completed5 enrollment criteria

Clinical Outcomes of 3L+ Therapies Among Patients With Chronic Myeloid Leukemia and Those With T315I...

Chronic Myeloid Leukemia

The study was a retrospective, non-interventional patient chart review and used a panel of oncologists/hematologists from the US to collect real-world clinical outcomes of patients with CML-CP in 3L+ and those with the T315I mutation.

Completed19 enrollment criteria

Study Conducted Among Patients With CML

Chronic Myeloid Leukemia

Retrospective, non-interventional observational cohort study conducted among patients with CML.

Completed10 enrollment criteria

Pharmacogenomics Validation for Imatinib in Chronic Myeloid Leukemia

LeukemiaMyelogenous2 more

This is a multicenter, retrospective, observational study to validate a pharmacogenetics model for imatinib metabolism and resistance in patients with chronic myeloid leukemia among patients in different independent cohort.

Completed6 enrollment criteria

Nilotinib in Adult Patients With Imatinib-resistant or Intolerant Chronic Myeloid Leukemia in Blast...

Chronic Myeloid Leukemia

Multi-center, open-label, non-randomized trial to evaluate long-term safety and efficacy of nilotinib. Approximately 20 patients will be enrolled in this trial at 3 centers in Mexico, which means all ongoing patients participating on [CAMN107A2109] excluding discontinued patients. During this study, patients will receive nilotinib orally, at a dose of 400 mg b.i.d. Patients will normally receive nilotinib on an outpatient basis. This trial will have a maximum of 24 months of follow-up time.

Approved for marketing9 enrollment criteria

Development of Immunological Assays for the Evaluation of Tumor Antigen Specific Immunity

Ovarian Serous AdenocarcinomaUndifferentiated Carcinoma of Ovary5 more

This study is a clinical study aiming at establishing immunological assays for the qualitative and quantitative evaluation of WT-1, Survivin and HPV16 E7-specific immune responses in cancer patients. Such a study will allow the development of suitable immunological tools to be used in assessing response in a subsequent phase I study aiming at evaluating therapeutic vaccine candidates targeting WT-1, Survivin and/or HPV16 E7-expressing tumors. In addition, this study will help defining the baseline cancer-associated immune responses in the selected patient population. Cervical and ovarian cancer patients, as well as leukemia patients, will be included in this study. WT-1, Survivin and HPV-specific immune responses will be monitored in these patients by ex vivo and cultured IFNg ELISpot as well as tetramer staining.

Completed17 enrollment criteria
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