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Active clinical trials for "Leukoplakia"

Results 21-30 of 49

Comparison Between Two Different High Power Ablative Lasers in the Treatment of Oral Leukoplakia...

Leukoplakic Lesions

Oral leukoplakia is a precancerous lesion with relatively high malignant transformation potential. They are often treated by wide surgical excisions or conservative retinoids therapy. The use of high power ablative lasers has been proposed as an effective way of treating these lesions safely. The aim of this study was to evaluate efficiency Er:YAG and Er,Cr:YSGG laser, in the treatment of oral leukoplakia.

Completed4 enrollment criteria

Aspirin Mouthwash in Treating Patients With Oral Leukoplakia

Precancerous Condition

RATIONALE: Aspirin mouthwash may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. PURPOSE: This phase I trial is studying the side effects and best dose of aspirin mouthwash in treating patients with oral leukoplakia.

Completed14 enrollment criteria

Treatment of Oral Premalignant Lesions With 5-ALA PDT

LeukoplakiaErythroplakia

Oral leukoplakia within the mouth is a visible white patch which can develop into cancer if not treated. There is no good treatment for these lesions, apart from surgery which is associated with significant side effects and physical deformation of the treated area. The investigators hypothesized that photodynamic therapy can be used safely and effectively to induce significant regression of oral leukoplakia.

Completed14 enrollment criteria

Photodynamic Therapy for Oral Precursor Lesions

LeukoplakiaLichen

Pre-malignant lesions are difficult to treat. Even after surgical removal they tend to re-appear. Often the lesions are to large and are apparent on many sites, therefore surgical removal is not always possible. The photodynamic therapy uses a special substance, which is absorbed in cells, and thereafter activated by a defined light. The aim of this study is to compare the photodynamic therapy in potentially malignant lesions to a placebo. The investigators assume a significant better result in photodynamic therapy then treatment with a placebo.

Completed15 enrollment criteria

Photodynamic Therapy for Oral Leukoplakia and Erythroleukoplakia

Oral Leukoplakia

Photodynamic therapy for oral leukoplakia and erythroleukoplakia

Completed2 enrollment criteria

Fenretinide in Treating Patients With Leukoplakia of the Mouth

Head and Neck Cancer

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of or treat early cancer. Fenretinide may be an effective drug in treating leukoplakia. PURPOSE: Randomized phase II trial to study the effectiveness of fenretinide in treating patients who have leukoplakia of the mouth.

Completed3 enrollment criteria

Intralesional 5-fluorouracil Injection for the Treatment of Oral Leukoplakia

Oral Leukoplakia

This is a single center, open-label, interventional pilot study to assess the feasibility, safety, and preliminary efficacy of intralesional 5-FU injections for the treatment of oral leukoplakia (OL).

Withdrawn13 enrollment criteria

Pioglitazone Hydrochloride in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia...

Head and Neck CancerOral Leukoplakia

This phase II trial studies how well pioglitazone hydrochloride works in preventing head and neck cancer in patients who have oral leukoplakia. Chemoprevention therapy is the use of certain drugs to try to prevent the development or recurrence of cancer. The use of pioglitazone hydrochloride may be effective in preventing head and neck cancer.

Completed33 enrollment criteria

Celecoxib in Preventing Head and Neck Cancer in Patients With Oral Leukoplakia

Head and Neck CancerPrecancerous Condition

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of celecoxib may prevent or treat head and neck cancer. PURPOSE: This randomized phase II trial is studying celecoxib to see how well it works compared to placebo in preventing head and neck cancer in patients with oral leukoplakia.

Completed56 enrollment criteria

Bowman-Birk Inhibitor Concentrate in Preventing Cancer in Patients With Oral Leukoplakia

Lip and Oral Cavity CancerOral Leukoplakia2 more

This randomized phase II trial is studying how well Bowman-Birk inhibitor concentrate works in preventing cancer in patients with oral leukoplakia. Chemoprevention is the use of certain substances to keep cancer from forming, growing, or coming back. The use of Bowman-Birk inhibitor concentrate, a substance made from soy, may keep cancer from forming in patients with oral leukoplakia

Completed14 enrollment criteria

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