Different Genetic Features Associated With Hepatic Carcinogenesis
Hepatocellular CarcinomaThe purpose of this study is to identify different genetic features in hepatocellular carcinoma. It will assist in predicting individual risks of disease progression and would help to clarify pathophysiological mechanisms of HCC.
Drug Monitoring of Sorafenib in Patients With Advanced Hepatocellular Carcinoma
Hepatocellular CancerSorafenib improves overall survival and progression free survival in advanced hepatocellular carcinoma. Wide interindividual pharmacokinetic variability was observed. Data from early phase trials in solid tumours showed trough sorafenib levels were associated with incidence of skin rash and hypertension. Rash, hypertension and higher trough levels were moderately predictive of progression free survival.The trough level of sorafenib may be predictive of survival and response in patients treated with sorafenib for advanced hepatocellular carcinoma.
Entecavir for Chronic Hepatitis B in Hepatocellular Carcinoma Patients Underwent Radiofrequency...
Chronic Hepatitis BHepatocellular CarcinomaPersistent replication of HBV (47-55%) is frequently found in patients with HCC, which in turn leads to deterioration of liver reserve. Moreover, a large proportion of HCC patients who underwent curative therapy died from progressive liver decompensation rather than recurrence of cancer. It had been proved that anti-viral therapy for hepatitis C virus (HCV)-related HCC patients could reduce the rate of tumor recurrence after surgical resection. This is a prospective study to evaluate the efficacy of ETV therapy in chronic hepatitis B patients after receiving RFA therapy for HCC.
Effect of Polymorphisms in the IL-1 Gene Complex on the Development of Chronic Hepatitis and Hepatocellular...
Hepatitis BCarcinoma3 moreThe purpose of this study is to determine the effect of polymorphisms in the IL-1 gene complex on the development of chronic hepatitis and hepatocellular carcinoma.
Gut Microbiota in People With Hepatocellular Carcinoma (HCC)
Hepatocellular CarcinomaLiver Cancer2 moreBackground: There are about 100 trillion microbial cells in a person s gut. This is called the human gut microbiota. When this is disrupted, it can lead to many diseases. Studies show that the gut microbiota in people with cancer is different than that found in healthy people. Researchers want to study links between the gut microbiota and the immune system in people with a liver disease called hepatocellular carcinoma (HCC). Objective: To study links between gut microbiota and the immune system in people with HCC. Eligibility: People at least 18 years old with HCC. They must be scheduled to have tumors removed by surgery. Design: People having surgery for primary liver tumors at the Mount Sinai Medical Center will be screened for this study. At the initial visit, blood, rectal swabs, urine, and stool will be collected. Participants will answer questions about their medical condition. Before surgery, blood, rectal swabs, urine, and stool will be collected. This will be done at a routine visit. When they have surgery, a piece of liver tissue with the tumor will be collected. This will be sent to the National Cancer Institute for tests. After surgery, blood, rectal swabs, urine, and stool will be collected 3 times. This will be done at routine visits.
Gadoxetic Acid-enhanced MR Evaluation of Hepatocellular Carcinoma and Dysplastic Nodules in the...
Liver CirrhosisCarcinoma1 moreA prospective intra-individual study to investigate the diagnostic performance of gadoxetic acid-enhanced MR for the patients with liver cirrhosis using thin-section whole-explant as standard of reference
Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of Actionable Events...
Hepatocellular CarcinomaTo collect tumor tissue from patients with liver masses suspicious for primary liver cancer. The research biopsy will be used to identify biomarkers in future studies.
A Humanitarian Device Exemption Treatment Protocol of TheraSphere For Treatment of Unresectable...
Liver CancerTo provide Therasphere treatment for patients diagnosed with unresectable liver cancer.
Continued Administration of G-202 for One Patient With Advanced Hepatocellular Carcinoma
Hepatocellular CarcinomaPatient with advanced liver cancer (cancer that has spread to other parts of the body) continues to receive the study drug (G-202) even though patient no longer meets the criteria to be a part of the main treatment study. Patient's cancer responded well to receiving G-202 in the main study and will receive G-202 at the same dose given in the main study.
Annual MRI Versus Biannual US for Surveillance of Hepatocellular Carcinoma in Liver Cirrhosis
Liver CirrhosisThe investigators will investigate the usefulness of biannual ultrasonography versus annual non-contrast magnetic resonance imaging for surveillance of hepatocellular carcinoma in single arm patients.