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Active clinical trials for "Liver Failure"

Results 231-240 of 412

Safety and Efficacy of ProQuad® in Children 6-24 Month Being Evaluated for Solid Organ Transplant...

RENAL INSUFFICIENCYCHRONIC3 more

A prospective, multisite study to evaluate the Impact of Measles, Mumps, Rubella and Varicella ProQuad® vaccination in pediatric patients 6-24 months of age who are being considered and/or evaluated for any solid organ transplant (heart, liver or kidney)

Completed8 enrollment criteria

A Study of Canagliflozin in Study Participants With Various Degrees of Impaired Hepatic (Liver)...

HealthyHepatic Insufficiency

The purpose of the study is to determine the concentration of canagliflozin in blood and urine samples after the administration of canagliflozin to study participants with mild or moderate hepatic (liver) impairment compared with study participants with normal hepatic function.

Completed8 enrollment criteria

Pharmacokinetics of Everolimus in Subjects With Hepatic Insufficiency

Hepatic Insufficiency

This clinical pharmacology research study will assess the safety and pharmacokinetics of the drug everolimus in patients with impaired hepatic function as compared to healthy volunteers.

Completed22 enrollment criteria

HEpatic Regeneration With COupled Plasma Filtration and Adsorption for Liver Extracorporeal Detoxification...

Liver FailureAcute2 more

CPFA is currently used in the treatment of severe sepsis with the intention of removing the proinflammatory mediators from the systemic circulation. Some evidence exists about the bilirubin adsorbing ability of the neutral styrenic resin which is part of the extracorporeal circuit of CPFA. The aim of this study is to assess efficacy and safety of CPFA in extracorporeal detoxification of liver toxins in patients affected by acute or acute-on-chronic liver failure.

Completed8 enrollment criteria

Clinical Pharmacology of FYU-981 (Subjects With Hepatic Insufficiency)

Hepatic InsufficiencyHealthy

The purpose of this study is to assess the pharmacokinetics, pharmacodynamics and safety after single oral administration of FYU-981 to subjects with hepatic insufficiency and with normal hepatic function.

Completed3 enrollment criteria

Evaluate the Pharmacokinetics, Safety, and Tolerability of Alisporivir in Subjects With Hepatic...

Hepatic Insufficiency

This is an open-label study to evaluate the pharmacokinetics, safety and tolerability of single oral doses of Alisporivir in subjects with mild and moderate hepatic impairment compared to matched healthy subjects with normal liver function.

Completed6 enrollment criteria

Pharmacokinetics of 9-cis-retinoic Acid (Alitretinoin, Toctino®) in Patients With Hepatic Disease...

Hepatic Insufficiency

This study aims to investigate whether liver patients may tolerate alitretinoin by comparing metabolism in 8 such patients with the metabolism in 8 healthy controls

Completed19 enrollment criteria

A Study of LY2140023 in Hepatically-Impaired Participants

Hepatic Insufficiency

This study will explore how liver impairment affects blood levels of LY2140023 (a prodrug) and its active metabolite (LY404039).

Completed66 enrollment criteria

Hepatic Impaired Subjects Compared to Healthy Subjects Receiving Multi-dose BMS-650032

Hepatic Insufficiency

The purpose of this study is to assess the effects of hepatic impairment on the multiple dose pharmacokinetics of BMS-650032.

Completed10 enrollment criteria

Study of Telaprevir in Subjects With Hepatic Impairment

Hepatic Insufficiency

The purpose of this study is to assess the safety and pharmacokinetics of Telaprevir following administration of multiple oral doses to subjects with moderate and severe hepatic impairment.

Completed3 enrollment criteria
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