Study Evaluating the Tolerance and Biological Activity of Oral Clioquinol in Patients With Relapsed...
Acute Myeloid LeukemiaAcute Lymphocytic Leukemia6 moreThis is an open-label, single arm phase 1 study to evaluate the dose-limiting toxicity, maximum tolerated dose, and recommended phase II dose of Clioquinol in patients with relapsed or refractory hematologic malignancies. The study will also characterize Cliquinol's safety, tolerability and pharmacodynamic effect.
Alvocidib in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma...
B-cell Chronic Lymphocytic LeukemiaContiguous Stage II Small Lymphocytic Lymphoma8 moreThis phase I trial is studying the side effects and best dose of flavopiridol in treating patients with B-cell chronic lymphocytic leukemia or small lymphocytic lymphoma. Drugs used in chemotherapy, such as alvocidib, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing.
Phase 1, Dose-Escalation Study of Oral CNF2024(BIIB021) in CLL
B-Cell Chronic Lymphocytic LeukemiaCLL dosing escalating study; daily dosing schedule; PK/PD safety
Rituximab Plus Beta-Glucan in Chronic Lymphocytic Leukemia(CLL)/Small Lymphocytic Lymphoma (SLL)...
LeukemiaLymphocytic3 moreThe purpose of this study is to determine how well subjects respond to treatment with Rituximab plus Beta-Glucan.
Study of mAb 216 With Chemotherapy for Treatment of Pediatric Relapsed or Refractory B-progenitor...
LeukemiaLymphocytic3 moreThis is a phase I trial in patients with relapsed or refractory leukemia of a human monoclonal antibody that kills B cell acute lymphoblastic leukemia. The trial will study the safety, pharmacokinetics, and anti-tumor activity of the antibody given as a single agent and with vincristine.
Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte Leukemia...
Stage III Chronic Lymphocytic LeukemiaStage IV Chronic Lymphocytic Leukemia1 moreThis phase II trial is studying how well tipifarnib works in treating patients with anemia or neutropenia and large granular lymphocyte leukemia. Tipifarnib may stop the growth of leukemia by blocking blood flow to the cancer cells and by blocking some of the enzymes needed for cancer cell growth.
Flavopiridol in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia
B-cell Chronic Lymphocytic LeukemiaProlymphocytic Leukemia1 moreThis phase II trial is studying how well flavopiridol works in treating patients with chronic lymphocytic leukemia or prolymphocytic leukemia. Drugs used in chemotherapy, such as flavopiridol, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing
Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic...
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaThe primary purpose of this study is to determine if motexafin gadolinium may be an effective treatment for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Secondly, the duration of response and the time during which patients survive without chronic lymphocytic leukemia or small lymphocytic lymphoma worsening will be evaluated. Additionally, the patient's response to motexafin gadolinium will be compared to the response of the patient's cells in a laboratory to motexafin gadolinium.
Campath-1H and Allogeneic Blood Stem Cell Transplantation for Lymphoid Malignancies
LeukemiaLymphocytic10 moreHigh dose chemotherapy followed by transplantation of allogeneic hematopoietic stem cell with the use of Campath-1h, a monoclonal antibody that have a synergistic effect to chemotherapy with minimal toxicity. In addition Campath-1H can improve engraftment of donor cells through its immunosuppressive properties.
CCI-779 in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia
Recurrent Adult Diffuse Large Cell LymphomaRecurrent Adult Hodgkin Lymphoma1 moreThis phase II trial is studying how well CCI-779 works in treating patients with relapsed or refractory chronic lymphocytic leukemia. Drugs used in chemotherapy, such as CCI-779, work in different ways to stop cancer cells from dividing so they stop growing or die