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Active clinical trials for "Depressive Disorder, Major"

Results 1511-1520 of 2240

Metyrapone as Additive Treatment in Major Depression

Major Depressive Disorder

The purpose of this study is to test whether metyrapone is an effective and safe augmenting agent in the treatment of major depression.

Completed9 enrollment criteria

Effects of Risperidone and Olanzapine on Patients With Schizophrenia, Schizoaffective Disorder,...

SchizophreniaSchizoaffective Disorder3 more

This twelve month, open-label study considers the effect of Risperdal (risperidone) versus Zyprexa (olanzapine) on weight gain, physical health, and outcome in a population of those diagnosed with schizophrenia, schizoaffective disorder, major depression or bipolar disorder with psychotic features. This study evaluates symptom response as well as general health indicators such as body mass index, glucose, prolactin, and cholesterol levels at baseline, month (M)1, M3, M6 and M12.

Completed22 enrollment criteria

Risperidone and Suicidality in Major Depressive Disorder

Depression

The purpose of this trial is to investigate the efficacy of risperidone as an adjunct to an antidepressant treatment in the acute management of suicidality during an episode of major depressive disorder.

Completed11 enrollment criteria

Deep Brain Stimulation for Treatment-Refractory Major Depression

Depression

This study will investigate the use of deep brain stimulation (DBS) to reduce symptom severity and enhance the quality of life for patients with treatment-refractory major depression.

Completed18 enrollment criteria

Study Evaluating DVS-233 SR and Venlafaxine ER in Adult Outpatients With Major Depressive Disorder...

Major Depressive Disorder

To compare the antidepressant efficacy and safety of DVS-233 SR versus placebo in adult outpatients with MDD.

Completed6 enrollment criteria

An 8 Week Depression Study In Adults Diagnosed With Major Depressive Disorder

Major Depressive Disorder (MDD)

A Placebo Controlled Study Evaluating Efficacy, Safety and Tolerability of Radafaxine in Patients with Major Depressive Disorder (MDD)

Completed10 enrollment criteria

Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major...

Major Depressive Disorder

The purpose of this study is to compare the safety and effectiveness of two treatments to prevent relapses in seriously ill patients with major depressive disorder (MDD) who have responded to electroconvulsive therapy (ECT). Patients will either continue to receive ECT (continuation electroconvulsive therapy [C-ECT]), or they will be treated with antidepressant medications. ECT is a highly effective treatment for MDD; however, relapses are a major concern. To prevent relapse in patients who have responded to ECT, the common treatment is antidepressants as continuation therapy (following the initial therapy in order to continue treating the disorder). Relapses, however, can still occur even after antidepressant continuation therapy. This study will evaluate a potent antidepressant combination in order to prevent relapse. C-ECT is another option that needs to be tested. If the patient responds to the first round of ECT, he/she will be assigned randomly (like tossing a coin) to either continue receiving ECT or to receive an antidepressant combination of nortriptyline plus lithium (NOR-Li) for 6 months. The patient will have psychological tests before, shortly after, and 3 months after the first round of ECT, and at the end of the 6-month continuation trial. Patients will be monitored for symptoms and side effects. All patients will have urine tests to test for drug abuse. An individual may be eligible for this study if he/she: Has major depressive disorder and responds positively to ECT treatment and is 18 to 80 years old.

Completed3 enrollment criteria

Assessing Dopamine Transporter Occupancy in the Healthy Adult Brain With Toludivenlafaxine Hydrochloride...

Major Depressive Disorder

This study was a single-arm, non-randomized, open-label clinical study to assess dopamine transporter occupancy in the brain of healthy adults using 11C-CFT positron emission tomography (PET)

Completed22 enrollment criteria

Effectiveness of a Mobile Texting Intervention for People With Serious Mental Illness

Schizoaffective DisorderSchizophrenia2 more

Testing an mHealth mobile interventionist texting program on illness management.

Completed7 enrollment criteria

Physical EXercise as an Adjunct Treatment for Depression

Major Depressive Disorder

35 participants diagnosed with major depressive disorder were randomized in 3 intervention groups: (1) aerobic exercise (AE) ; (2) placebo (stretching) exercise (ST); and (3) no intervention (control group; NI). The intervention length was 10 consecutive days. In groups 1 (aerobic exercise) and 2 (sham exercise), participants exercised for 30 minutes each day. Depressive symptoms were assessed the day before the beginning of intervention and the day after the end of intervention for participants of both groups.

Completed6 enrollment criteria
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