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Active clinical trials for "Melanoma"

Results 2141-2150 of 2584

Regorafenib, C-kit Mutated Malignant Melanoma, 2nd Line Therapy

Melanoma

This is a phase II trial of regorafenib in patients with metastatic melanoma harboring c-Kit mutations and/or amplifications of c-Kit gene copy number. The primary end point is disease control rate (DCR), and the secondary end points are safety, response rate (RR), progression free survival (PFS), and overall survival (OS).

Unknown status16 enrollment criteria

In-hospital Neutron Irradiator (IHNI)-Based Boron Neutron Capture Therapy (BNCT) in the Treatment...

MelanomaBoron Neutron Capture Therapy

Boron Neutron Capture Therapy (BNCT) has been used in the treatment of several types of malignant tumors, including malignant melanoma, high-grade gliomas, and advanced head and neck cancers. Theoretically, it represents a more precise radiotherapy in that it could spare normal cells while destroy malignant ones. However, its value is largely restricted by the fact that it could only be performed in the nuclear research reactors, the only neutron source at the time. In 2010, the world's first in-hospital neutron irradiator (IHNI) had been constructed in Beijing, China, and this study aims to evaluate whether IHNI has the potential to serve as an effective in-hospital neutron source for BNCT.

Unknown status18 enrollment criteria

A Study Investigating SGI-110 in Combination With Ipilimumab in Unresectable or Metastatic Melanoma...

Metastatic Melanoma

Thi pahse I, dose-escalation trial will determine the MTD, safety and the additional benefit achieved from adding SGI-110 to ipilimumab therapy in metastatic melanoma patients. Preclinical evidence generated with SGI-110 in vivo demonstrated that besides having a direct activity on tumor growth as a single agent, SGI-110 was able to "sensitize" neoplastic cells to the anti-tumor activity of CTLA-4 blockade, providing a sound scientific rationale to develop new immunotherapeutic approaches combining SGI-110 with therapeutic mAb to immune check-points.

Unknown status21 enrollment criteria

Early FDG PET in Melanoma

Clinical Stage III Nodal or Intransit Disease or Resectable Stage IV Melanoma

Adult patients with histologically proven melanoma who will be treated with pembrolizumab will undergo FDG PET/CT scan as an early evaluation of response to therapy. Changes in FDG uptake will be correlated with lab and pathology results.

Terminated9 enrollment criteria

Everolimus in Selected Patients With Metastatic Melanoma: Efficacy and Safety Study

MelanomaTOR Serine-Threonine Kinases1 more

This is a single-armed, open-labeled and single-centered study of everolimus in selective patients with metastatic melanoma for evaluation of the efficacy and safety. The study objective is to evaluate efficacy profile of everolimus. The patients who comply with the inclusion and exclusion criteria will be enrolled. The estimated recruiting duration is 18 months. Everolimus will be given in the dose of 10 mg orally each day at lease 6 months unless disease progression or intolerance. The follow-up is till death(at least 1 year).

Unknown status3 enrollment criteria

Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal...

Head and Neck Squamous Cell CarcinomaMetastatic Renal Cell Cancer7 more

This randomized clinical trial studies radiation therapy and MK-3475 in treating patients with head and neck cancer, kidney cancer, melanoma, or lung cancer that has returned, has spread to other parts of the body, or cannot be removed by surgery. Radiation therapy uses high-energy x-rays to kill tumor cells. Monoclonal antibodies, such as MK-3475, may block tumor growth by targeting certain cells and causing the immune system to attack the tumor. Studying the effects of MK-3475 with radiation therapy on the body may help doctors learn whether it may be an effective treatment for these solid tumors.

Unknown status36 enrollment criteria

Study With T-cel Receptor Gene Therapy in Metastatic Melanoma

Stage IV Skin MelanomaEye; Melanoma

Patients with stage IV melanoma (also eye melanoma) will be treated with TCR transduced cells.

Unknown status17 enrollment criteria

Mohs and Immunofluorescence for Malignant Melanoma In Situ

Lentigo MalignaMelanoma In Situ

The purpose of this study is to determine if immunofluorescence (IF) can effectively identify features of malignant melanoma in situ, on sun-damaged skin, in the setting of Mohs Micrographic Surgery.

Withdrawn23 enrollment criteria

Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration

Melanoma

Procure Tumor and Initiate Melanoma Tumor-Reactive Tumor Infiltration Lymphocytes (TIL)

Terminated7 enrollment criteria

Rituxan and Abraxane for the Treatment of Patients With Inoperable Stage III and IV Malignant Melanoma...

Malignant Melanoma of Skin Stage IIIMetastatic Melanoma

The purpose of this research study is to test an experimental combination of drugs to determine if they can cause shrinkage or even complete disappearance of your melanoma. The two drugs being tested in combination are Rituxan and Abraxane

Unknown status29 enrollment criteria
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