FLuorescence Identification of Melanoma by a Multicenter Based Algorithm (FLIMMA)
MelanomaMolesAll patients will undergo dermoscopic diagnosis and be documented with a video image storing. The diagnosis based on dermoscopy will be immediately documented. Then, as a second diagnostic procedure, fluorescence diagnostics based on the two photon excitation from a dye-laser will be performed. The classification as non-melanoma or malignant melanoma by the medical device LIMES will also be documented immediately. Afterwards, the lesion will be excised and undergo histopathologic examination by the respective histopathologist of the participating centers. The histopathologic diagnosis will serve as gold standard for subsequent evaluations of the diagnostic accuracy.
Comparison of In-House Methods and Cobas BRAF V600 Mutation Assay in Melanoma Tumor Samples
Malignant MelanomaThis non-interventional study will compare the Cobas BRAF V600 mutation assay with in-house methods used in molecular laboratories for the assessment of the BRAF mutation status in melanoma tumor samples. No patients will be enrolled in this study. Data will be collected for approximately 6 months.
Expanded Access Study of Melphalan With Delcath CS-PHP System in Patients With Ocular/Cutaneous...
Metastatic Liver CancerOcular Melanoma1 moreThe safety and efficacy of CS-PHP-melphalan has been evaluated in a phase 3 trial conducted in the same patient population as well as using the same melphalan dosing as proposed in this study. This expanded access protocol will provide an experimental alternative treatment option for both physicians and patients until the Delcath CS-PHP System receives marketing approval.
Identification of Marker of Primary or Acquired Resistance to Anti Tumorous Treatment
MelanomaNon Small Cell Lung Cancer1 moreLung Cancer and melanoma relapsed frequently whereas its very sensitive to treatment such as chemotherapy or radiotherapy. The purpose of this study is to have a better understanding of why those patients are relapsing using next generation sequencing to identify rare mutations and assessed their predictive value.
Non-invasive Melanoma Assessment Using a Topical Fluorescence Reagent and Optical Imaging
Skin LesionThe use of MDS to access the presence of melanoma in the skin.
Non-invasive Melanoma Assessment Using a Topical Fluorescence Reagent and Optical Imaging
Skin LesionsThe use of MDS to access the presence of melanoma in the skin.
Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced...
Malignant Neoplasm of BreastHodgkin Disease7 moreIdentify the best combination of predictive variables that influence ionizing radiation dose and improved image quality through analysis and quantification of PET-CT images in simulators and patients.
Circulating Tumor Cells and Melanoma: Comparing the EPISPOT and CellSearch Techniques
Metastatic MelanomaThe main objective of this study is to compare results for the detection of circulating melanoma cells (CMC) using CellSearch versus EPISPOT (EPithelial ImmunoSPOT) techniques between a group of patients with metastatic melanoma and a group of hospitalized control patients.
Intraoperative Mapping of Regional Lymphatics Draining the Primary Site of Melanoma Using Isosulfan...
MelanomaThe purpose of this study is to determine whether we can consistently identify the first lymph node (the "sentinel node") draining your melanoma.
Health Communication in Families
Lung CancerMelanoma1 moreThere are two goals of this research study. First, we hope to develop a plan to guide family discussions that can help parents diagnosed with lung cancer talk about cancer risk with their adult children. Second, we want to understand how families talk about cancer prevention.