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Active clinical trials for "Bipolar Disorder"

Results 911-920 of 1390

Cognitive and Psychophysiological Effects of Delta-9-Tetrahydrocannabinol in Bipolar Disorder

Delta-9-TetrahydroncannabinolBipolar Disorder1 more

The overarching goal of this study is to characterize the acute cognitive and psychophysiological effects of the main psychoactive constituent of cannabis, 9-delta-tetrahydrocannabinol (THC) in individuals with euthymic bipolar disorder (BD), and to begin probing the mechanisms that may underlie its effects in this illness. This study is expected to contribute to a better characterization of specific effects of THC in individuals with BD compared to healthy controls (HC).

Terminated13 enrollment criteria

Gao NARASD Lithium Study

Bipolar Disorder

This study is a 4-month open-label study of lithium in the acute treatment of patients with bipolar I or II disorder. Eligible patients will receive lithium 300 mg twice daily and titrated in 300 mg increments every 7 days as tolerated to levels > 0.6 mEq/L. Blood samples are collected at baseline and at the end of study. Analyses of 45 molecule expressions in mononuclear blood cells at baseline and endpoint will be carried out after the completion of study. Fifty patients meeting Diagnostic and Statistical Manual of Mental Disorders-5 (DSM-5) criteria for bipolar I or II will be enrolled.

Terminated24 enrollment criteria

Improving Mental Health Outcomes: Building an Adaptive Implementation Strategy

Bipolar DisorderDepression1 more

The overarching goal of this study is to build the most cost-effective adaptive implementation intervention involving a site-level implementation intervention strategy: Replicating Effective Programs (REP), and the augmentation of REP using either External Facilitation or a combination of an External and Internal Facilitation to improve patient outcomes and the uptake of an evidence-based program for mood disorders (Life Goals-LG) in community settings.

Terminated5 enrollment criteria

Light at Night Study

Bipolar DisorderLight Sensitivity

The purpose of this mechanistic study is to examine light sensitivity (melatonin suppression) in people with bipolar depression I, and compare it to healthy controls. This is not a treatment study.

Terminated7 enrollment criteria

Side Effect Study of Antipsychotic Medicines to Treat Childhood Bipolar Disorder

Bipolar Disorder

The purpose of this study is to learn more about weight gain and related side effects when children are treated with antipsychotic medicine for mood disorders.

Terminated21 enrollment criteria

Magnetic Seizure Therapy vs. Electroconvulsive Therapy for Bipolar Mania

Bipolar DisorderManic

This trial attempts to evaluate the treatment efficacy of magnetic seizure therapy (MST) and its safety for bipolar mania. Half of the participants will receive MST, while the other half will receive electroconvulsive therapy (ECT).

Withdrawn10 enrollment criteria

A Safety and Efficacy Study of Ramelteon Tablets for Sublingual Administration (TAK-375SL) in the...

Bipolar Disorder

To evaluate the efficacy and safety of once a day ramelteon tablets for sublingual administration (TAK-375SL) in the maintenance treatment of bipolar 1 disorder.

Withdrawn49 enrollment criteria

Prevention of Mood Disorders by Folic Acid Supplementation

DepressionBipolar Disorder

The purpose of this study is to determine whether daily folic acid supplements can prevent new episodes of mood disorder in young people (aged 14-24 years) of biological parents with current or past history of depression or bipolar disorder.

Completed12 enrollment criteria

Functional Connectivity in Mood Regulating Circuit In Bipolar Depression and Mania

Bipolar Depression

The purpose of this study is to find out what parts of the brain have increased or decreased activity with individuals who have bipolar disorder and how medicine changes this activity in bipolar subjects. Another purpose of this study is to compare data obtained from bipolar depressed subjects with data obtained from healthy subjects. In this study we will measure activity in different parts of the brain, while participants see pictures, using Magnetic Resonance Imaging (MRI) scan. We will do two MRI scans with each subject before and after treatment for eight weeks with a standard bipolar disorder medication called lithium.

Completed30 enrollment criteria

Early Family-Focused Treatment for Youth at Risk for Bipolar Disorder

Bipolar Disorder

This study will test a family-based therapy aimed at preventing or reducing the symptoms of bipolar disorder in at-risk children.

Completed15 enrollment criteria
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