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Active clinical trials for "Marijuana Abuse"

Results 181-190 of 435

Safety and Efficacy of a FAAH-Inhibitor to Treat Cannabis Withdrawal

Cannabis Dependence

Cannabis dependence is associated with changes in the brain's cannabinoid system. When cannabis dependent individuals try to quit using cannabis, some of them experience problems that make it difficult for them to achieve and maintain abstinence. Therefore, reducing the problems related to quitting cannabis may facilitate abstinence. One way to do this is by harnessing the brain's capacity to make its own cannabis-like substances - endocannabinoids. One of the main endocannabinoids is anandamide. The study is based on the hypothesis that the problems related to quitting cannabis use will be reduced by increasing the brain levels of anandamide. Furthermore, by reducing the problems related to quitting cannabis, people will be less likely to relapse. Brain anandamide levels will be increased by blocking the breakdown of anandamide using a fatty acid amide hydrolase inhibitor (FAAH-I). The effects of a novel FAAH-I cannabis withdrawal and relapse in cannabis dependent subjects will be studied in a double-blind, randomized, controlled, proof-of-concept study. Cannabis-dependent subjects will receive placebo or the FAAH-inhibitor PF-04457845 in a 2:1 randomization. The trial consists of a 1 week inpatient stay to achieve abstinence, a 3 week outpatient treatment phase. Cannabis withdrawal will be measured during the inpatient phase. Cannabis use and urinary THC-COOH levels will be measured during the entire study. The treatment phase will be followed by a safety follow up phase of 8 weeks.

Completed5 enrollment criteria

Targeting Tobacco Cessation During Treatment for Cannabis Use Disorders

Cannabis Dependence

This project aims to develop and test an intervention for the simultaneous treatment of cannabis use disorders and tobacco smoking. This is important because over 50% of adults seeking treatment to help stop cannabis use also smoke tobacco regularly, which decreases their chance for a successful treatment outcome and increases adverse acute and long-term psychosocial and health consequences. The proposed treatment will integrate existing computer-based behavioral interventions for cannabis and tobacco and use nicotine replacement medications to improve outcomes in this difficult to treat clinical population.

Completed15 enrollment criteria

Integrated CBT for Cannabis Dependence With Co-occurring Anxiety Disorders

Cannabis DependenceAnxiety Disorders2 more

This project tests the feasibility and utility of a novel, integrated approach to treatment of patients with cannabis use disorder (CUD) and anxiety disorders.

Completed19 enrollment criteria

Dronabinol Interactions With Cognitive Enhancing Drug in Humans

CannabisMarijuana Abuse

Marijuana use is a major problem among veterans and non-veterans. A patient's use of marijuana while engaged in psychotherapy treatment may affect their memory and, therefore, limit their ability to benefit from treatment. This study is designed to test a new pharmacotherapy, modafinil, which has the potential to improve memory functioning in marijuana using individuals. We hypothesize that modafinil treatment will decrease ratings of drug liking and improve cognitive measures, especially episodic memory.

Completed16 enrollment criteria

Combined Pharmacotherapy for Cannabis Dependency

Cannabis DependenceMarijuana Dependence

The purpose of this study is to see if Lofexidine in combination with Marinol is superior to placebo in achieving abstinence, reducing cannabis use and reducing withdrawal in cannabis-dependent patients seeking treatment for their marijuana use.

Completed19 enrollment criteria

Nabilone & Marijuana Addiction

Marijuana Smoking

Safety of Nabilone in reducing marijuana craving

Completed2 enrollment criteria

A Placebo-Controlled Trial of Buspirone for Treatment of Marijuana Dependence

Marijuana Abuse

The purpose of this study is to determine if buspirone combined with motivational enhancement therapy is effective in reducing marijuana use in marijuana-dependent adults.

Completed15 enrollment criteria

Study of Quetiapine Treatment for Cannabis Dependence

Cannabis Dependence

Marijuana is the most commonly used illicit drug in the United States. However, the treatment options for cannabis dependence are limited; notably, no effective pharmacotherapy has been developed. Conceptually, the ideal medication treatment for cannabis dependence would: be safe when administered to patients actively using cannabis reduce cannabis intake and promote abstinence treat the symptoms of cannabis withdrawal reduce craving and relapse risk have a low abuse liability.

Completed15 enrollment criteria

Motivational Interviews for Incarcerated Teens - 1

Alcoholic IntoxicationMarijuana Abuse

The purpose of this study is to test the efficacy of an individual motivational interview for reducing alcohol and marijuana-related harm as well as alcohol and marijuana use in incarcerated teens.

Completed2 enrollment criteria

Effect of Cannabis (Marijuana) on Stomach Emptying Before Surgery

Gastric EmptyingCannabis

The purpose of this research is to study the effect of cannabis (marijuana) on gastric (stomach) emptying before surgery. The study will include people who use cannabis (study group) and people who do not use cannabis (control group).

Not yet recruiting13 enrollment criteria
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