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Active clinical trials for "Melanoma"

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A Pilot Study of Pivanex in Patients With Malignant Melanoma

Malignant Melanoma

This pilot study will assess the safety and efficacy of Pivanex alone in patients with malignant melanoma who have relapsed after treatment with chemotherapy or Interleukin-2 (IL-2). Pivanex is an investigational agent.

Terminated20 enrollment criteria

A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas...

Metastatic Melanoma

The purpose of this protocol is to determine whether autologous TIL infused in conjunction with systemic high-dose IL-2 after non-myeloablative chemotherapy with cyclophosphamide and fludarabine can cause consistent and durable objective responses in patients who have metastatic melanoma at the John Wayne Cancer Institute (JWCI).

Terminated31 enrollment criteria

Rituximab in Metastatic Melanoma

Metastatic Melanoma

The purpose of this study is to determine whether rituximab as an adjuvant therapy in clinical stage IIIc / IV (no evidence of disease, AJCC (American Joint Committee on Cancer) 2002) melanoma patients is safe and prolongs overall survival and disease-free interval.

Terminated12 enrollment criteria

Eligibility Screening for the NIH Intramural Research Program Clinical Protocols

Breast CancerProstate Cancer3 more

The purpose of this protocol is to provide patients with adequate informed consent to understand that screening tests with minimal health risk will be performed to evaluate their eligibility for a research study. The protocol makes it clear that patients initial visit to the intramural clinical program may include screening studies that are not medically necessary for disease management, but are done purely for research purposes. Patients with a known or suspected diagnosis of cancer, HIV infection, skin disorder or immunodeficiency who are being considered for enrollment in a National Cancer Institute intramural clinical research protocol will participate in this consent protocol. It informs patients of screening tests and procedures involving minimal risk that are done for research purposes only, including blood tests, electrocardiogram, standard X-rays (e.g., chest X-ray), bone films, computed tomography (CT), magnetic resonance imaging (MRI), and nuclear medicine studies. It explains that other eligibility screens that are more invasive and involve greater risk, such as a biopsy, will require separate consent.

Enrolling by invitation3 enrollment criteria

Sentinel Lymph Node Detection in Patients With Stage Ib-III Melanoma Using MSOT and ICG

MelanomaStage I3 more

In this study the investigators try to identify the sentinel lymph node in patients with stage Ib-III melanoma in a non-invasive manner without the use of a radioactive tracer by using the new MSOT technology.

Not yet recruiting11 enrollment criteria

Investigating the Diagnostic Potential of Tear Proteins in Cancer - A Pilot Study

Breast CancerOvarian Cancer3 more

This Pilot Study is to investigate the tear proteins in a multitude of cancer types and indulge in biomarker discovery to manufacture simple, accurate, and novel tear-based diagnostic tests.

Enrolling by invitation8 enrollment criteria

Follow Up Protocol for Subjects Previously Enrolled on NCI Surgery Branch Studies

MelanomaAdenocarcinoma2 more

Background: The NCI Surgery Branch has developed experimental therapies that involve taking white blood cells from participants' tumor or from their blood, growing them in the laboratory in large numbers, and then giving the cells back to the patient. Objective: This study will allow participants to be followed for up to 15 years following treatment on an NCI Surgery Branch Gene Therapy Trial as required by the FDA. Eligibility: Participants must have been enrolled on an NCI Surgery Branch Gene Therapy Protocol Design Participants will be followed with a physical examination and blood tests for up to 15 years as required by the FDA

Enrolling by invitation4 enrollment criteria

Immunization of Disease-Free Melanoma Patients With Different HLA-A2 Peptides

Melanoma

Open-label single center study. Patients will be divided in four groups of 7. Group 1: 8 melanoma-specific peptides in saline; Group 2: same mix of peptides + Montanide ISA51; Group 3: same mix of peptides + IMP321 500 µg; Group 4: same mix of peptides + IMP321 500 µg + Montanide ISA51. These vaccines will be administered every 3 weeks on 5 occasions by intradermal and superficial subcutaneous injections.

Terminated15 enrollment criteria

Interleukin-2 in Metastatic Melanoma

Melanoma Metastatic

To determine whether Interleukin-2 at the dose and schedule will help to increase tumor shrinkage

Terminated15 enrollment criteria

Clinical Evaluation of Yervoy in Combination With Adoptive T Cell Transfer for Metastatic Melanoma...

A Combination of Adoptive T Cell Therapy and Ipilimumab Could Increase the Proportion of CR Patientsand Durability of Response

A rationally designed combination of adoptive T cell therapy and ipilimumab could strongly increase the proportion of CR patients, as well as the durability of response, as compared to ipilimumab or TIL alone. The investigators hypothesize that the combination of those two important modalities could result in a durable (≥ 1 year) complete response rate of 30% in stage IV melanoma patients.

Terminated40 enrollment criteria
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